Spatio-temporal control of light-driven plasmonic and photoswitchable nanoagents (A08)

光驱动等离子体和光开关纳米剂的时空控制（A08）

• 批准号: 225005280
• 金额: --
• 依托单位: Lehrstuhl für Photonik und Optoelektronik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/225005280?language=en
• 关键词: Spatio; temporal; control; light; driven

This project aims at the design of nanoagents whose operation can be controlled by light. First, we will devise a method to precisely measure temperature distributions and control molecular absorption and desorption on plasmonic nanostructures by a combination of optothermal manipulation and super-resolution microscopy. Secondly, we will investigate how plasmonic DNA-origami nanopores can be incoorporated into lipid bilayer membranes for SERS measurements of single molecules and DNA. Finally, we will explore the use of photolipids as nanoagents to control characteristic membrane properties. In particular, we want to investigate the conditions for two-photon photoisomerization of photoswitchable nanoagents, which is imperative for their application in cellular environments and 3D matrices.

该项目旨在设计可以通过光控制其操作的纳米剂。首先，我们将设计一种方法来精确地测量温度分布和控制分子的吸收和解吸等离子体纳米结构的光热操纵和超分辨率显微镜的组合。其次，我们将研究如何等离子体DNA折纸纳米孔可以嵌入到脂质双层膜的Sers测量的单分子和DNA。最后，我们将探索使用光脂作为纳米剂来控制膜的特性。特别是，我们要调查的条件，为双光子光异构化的光开关纳米剂，这是必不可少的，他们在细胞环境和3D矩阵中的应用。