MRI: Acquisition of a Goniometer-Based Light Scattering System for Research and Training at the University of Mississippi

MRI：密西西比大学购买基于测角仪的光散射系统用于研究和培训

• 批准号: 1625813
• 负责人: Adam Smith
• 金额: $ 11.03万
• 依托单位: University of Mississippi
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-01 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1625813&HistoricalAwards=false
• 关键词: MRI; Acquisition; Goniometer; Based; Light

With this award from the Major Research Instrumentation (MRI) program, the University of Mississippi (UM) will acquire a goniometer-based light scattering instrument. Light scattering is a versatile tool for the non-destructive characterization of a wide variety of systems including synthetic polymers, biopolymers such as proteins and nucleic acids, and suspensions of colloidal particles. The instrument utilizes a laser to interact with particles in a sample. As the particles scatter light from the laser, they impart information about their motion in solution. The analysis of this information allows researchers to determine a wealth of information including the size, shape, and interactions of the particles in solution without requiring a substantial investment in sample preparation or method development. A multidisciplinary team of UM researchers from chemical engineering, chemistry, and pharmaceutics will oversee the acquisition and operation of the light scattering instrument. The acquisition will enhance the training of both undergraduate and graduate researchers in the use of modern analytical techniques for materials characterization and will be incorporated in courses taken by undergraduate and graduate students at the University of Mississippi.The acquisition of a light scattering instrument capable of simultaneous static and dynamic light scattering measurements will enhance research in the areas of (a) self-assembly of stimuli- responsive block copolymers in solution, (b) development of cellulose nanocrystals for underground CO2 sequestration, (c) the examination of microenvironmental factors that influence cell adhesion by transmembrane proteins, (d) the development of redox-responsive polymer nanoparticles for triggered drug release, (e) the development of stimuli-responsive nucleic acid delivery vehicles, (f) an investigation on multifunctional graphene-polymer nanocomposites, and (g) the study of structure-property models of Janus dendrimers for sustained release

密西西比大学(UM)将从主要研究仪器(MRI)计划获得这一奖项，从而获得一种基于测角仪的光散射仪器。光散射是一种多用途的工具，可用于对各种系统进行无损表征，包括合成聚合物、蛋白质和核酸等生物聚合物以及胶体颗粒的悬浮液。该仪器利用激光与样品中的颗粒相互作用。当粒子散射来自激光的光时，它们会传递有关它们在溶液中运动的信息。对这些信息的分析使研究人员能够确定大量信息，包括溶液中颗粒的大小、形状和相互作用，而不需要在样品准备或方法开发方面进行大量投资。一个由来自化学工程、化学和制药学的UM研究人员组成的多学科团队将监督光散射仪器的获取和操作。这项收购将加强本科生和研究生在使用现代分析技术进行材料表征方面的培训，并将被纳入密西西比大学本科生和研究生的课程。收购能够同时进行静态和动态光散射测量的光散射仪器将加强以下领域的研究：(A)刺激响应型嵌段共聚物在溶液中的自组装，(B)用于地下二氧化碳封存的纤维素纳米晶的开发，(C)影响细胞通过跨膜蛋白黏附的微环境因素的检查，(D)用于触发药物释放的氧化还原响应型聚合物纳米颗粒的开发，(E)开发响应刺激的核酸输送工具，(F)研究多功能石墨烯-聚合物纳米复合材料，以及(G)研究用于缓释的Janus树枝状大分子的结构-性能模型