I-Corps: Developing the Value Proposition for the Rapid Detection and Classification of Designer Drugs

I-Corps：制定设计药物快速检测和分类的价值主张

• 批准号: 1632224
• 负责人: Roger West
• 金额: $ 5万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-03-01 至 2017-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1632224&HistoricalAwards=false
• 关键词: Corps; Developing; Value; Proposition; Rapid

The I-Corps team presents a portable electrochemical detection device that can rapidly detect narcotics. Law enforcement agencies and medical treatment facilities use low-cost reagent tests to rapidly detect suspected narcotics in the field. However, these tests lack molecular specificity and are prone to false positives. Additionally, the reagent tests can only detect a limited class of narcotics and are not adequate for the routine detection of designer and prescription drugs. Therefore, the motivation behind the portable electrochemical detection device was to create an inexpensive chemical sensor for law enforcement agencies to reproducibly and accurately detect multiple classes of drugs. Electrochemical techniques have been used for decades in laboratories to detect chemicals and biological agents. The conventional and portable instrumentation used for electrochemical detection is expensive, cumbersome and require special skills. The portable electrochemical detection device presented by this I-Corps team addresses the above challenges by using inexpensive sensors in a compact and portable container that is easy to use. This device is expected to impact many fields including quality control monitoring of agriculture produce and fine chemical products and intermediates.The electrochemical device presented here utilizes a paper-based electrode with carefully engineered channels to allow separation of the suspected drug from the matrix. The drug migrates along laminar flow in the channels based on their physical properties until it reaches the detection area of the electrode. The detection area has three conductive-ink/paste-based electrodes that are used for the amperometric measurement of the drug. The I-Corp team intends to perform a product-market analysis for the commercialization potential of the portable electrochemical detection device. Direct conversations with prospective customers will allow for greater understanding of each industrial sector?s pain points for routine chemical analysis outside of the laboratory. Participation will also help the I-Corp team clarify the direction the technology can take going forward such as product development issues to meet identified specific market needs.

I-Corps团队提出了一种便携式电化学检测设备，可以快速检测毒品。执法机构和医疗机构使用低成本的试剂测试来快速检测现场的疑似毒品。然而，这些测试缺乏分子特异性，并且容易出现假阳性。此外，试剂测试只能检测有限类别的麻醉品，不足以用于常规检测设计师和处方药。因此，便携式电化学检测设备背后的动机是为执法机构创造一种廉价的化学传感器，以可重复地准确检测多种类型的药物。电化学技术已经在实验室中使用了几十年来检测化学品和生物制剂。用于电化学检测的常规便携式仪器昂贵、笨重且需要特殊技能。这个I-Corps团队提出的便携式电化学检测设备通过在易于使用的紧凑便携式容器中使用廉价的传感器来解决上述挑战。该装置预计将影响许多领域，包括农产品和精细化工产品和中间体的质量控制监测。本文介绍的电化学装置利用具有精心设计的通道的纸基电极，以允许从基质中分离可疑药物。药物基于其物理性质在通道中沿着层流迁移，直到其到达电极的检测区域。检测区域有三个导电油墨/糊状电极，用于药物的电流测量。I-Corp团队打算对便携式电化学检测设备的商业化潜力进行产品市场分析。与潜在客户的直接对话将使您更好地了解每个工业部门？实验室外常规化学分析的痛点。参与还将有助于I-Corp团队明确技术的发展方向，例如产品开发问题，以满足已确定的特定市场需求。