SBIR Phase II: Millimeter-Scale Wireless Sensor Node for Intracranial Pressure Monitoring

SBIR 第二阶段：用于颅内压监测的毫米级无线传感器节点

• 批准号: 1632483
• 负责人: ZhiYoong Foo
• 金额: $ 74.06万
• 依托单位: CubeWorks Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2018-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1632483&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Millimeter; Scale

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project allows for the realization of a commercial millimeter-scale intracranial pressure (ICP) monitoring product that can help neurosurgeons in treating patients with hydrocephalus. While the goal of this SBIR Phase II project is the development of said ICP monitor, the technology can also be translated to the development of 'smart dust', opening up the next generation of computing paradigm. This will mark a significant milestone towards massive-scale realization of internet of things, dramatically accelerating the technology adoption and research impact of millimeter-scale wireless sensor nodes. The technology adoption can be introduced to multiple markets including, but not limited to, medical, industrial, and consumer spaces. This would open up many new commercial opportunities that were previously limited by energy consumption and size, heralding a new era of computing in an unprecedented form factor and lifetime.This Small Business Innovation Research (SBIR) Phase II project focuses on the development of a millimeter-scale intracranial pressure (ICP) monitoring for improved treatment of hydrocephalus. Hydrocephalus is a condition in which cerebrospinal fluid (CSF) builds up in the brain's ventricle area, causing head enlargement, epilepsy, and death. The only practical treatment for hydrocephalus is surgical implant of medical shunts, which relieves excess CSF to other parts of the body. The biggest problem with existing shunts is that they lack any embedded monitoring feature. Once the shunt is installed, there is no way to measure the internal pressure outside of hospital settings. The proposed monitor enables a 'smart shunt' solution, which continuously records ICP information inside the shunt for many years. This data is read out wirelessly and can be used to prevent shunt failures and improve the treatment of this lifelong disease.

该小型企业创新研究（SBIR）II期项目的更广泛影响/商业潜力允许实现商业毫米级颅内压（ICP）监测产品，可帮助神经外科医生治疗脑积水患者。虽然SBIR第二阶段项目的目标是开发上述ICP监测器，但该技术也可以转化为“智能灰尘”的开发，开辟下一代计算模式。这将标志着物联网在大规模实现方面的一个重要里程碑，大大加速了毫米级无线传感器节点的技术采用和研究影响。该技术的采用可以引入多个市场，包括但不限于医疗、工业和消费领域。这将开启许多以前受限于能耗和尺寸的新的商业机会，预示着一个前所未有的外形尺寸和寿命的计算新时代的到来。这个小型企业创新研究（SBIR）第二阶段项目的重点是开发毫米级颅内压（ICP）监测，以改善脑积水的治疗。脑积水是一种脑脊髓液（CSF）积聚在脑室区域的疾病，可导致头部肿大、癫痫和死亡。脑积水的唯一实际治疗方法是外科植入医疗分流器，将多余的CSF释放到身体的其他部位。现有分流器的最大问题是它们缺乏任何嵌入式监控功能。一旦安装了分流器，就无法在医院环境之外测量内部压力。所提出的监测器实现了“智能分流器”解决方案，该解决方案连续多年记录分流器内的ICP信息。这些数据通过无线方式读取，可用于预防分流失败，并改善这种终身疾病的治疗。