Multi-Scale Metabolic Modeling and Engineering Workshop

多尺度代谢建模与工程研讨会

• 批准号: 1637780
• 负责人: Justin Barone
• 金额: $ 1.73万
• 依托单位: Virginia Polytechnic Institute and State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2018-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1637780&HistoricalAwards=false
• 关键词: Multi; Scale; Metabolic; Modeling; Engineering

The Multi-Scale Metabolic Modeling and Engineering Workshop will be held at the Virginia Tech National Capital Region (NCR) campus in Arlington, VA, during August of 2016. This workshop will synthesize the latest academic developments in metabolic engineering into useful and translatable information for the bioprocessing industry.The workshop participants will be a combination of industrial and academic researchers who identify as bioprocess engineers, metabolic engineers, protein engineers, and synthetic biologists..The application of metabolic engineering methodologies to industrial fermentation can have significant impact on the efficient production of pharmaceuticals, chemicals, and biofuels. The workshop will explore how to better integrate metabolic engineering principles and modeling with industrial bioprocess engineering models through the following topics: 1) Use of SuperPRO Designer to evaluate bioprocess economics and assess the impacts of metabolic engineering on improving and enhancing these bioprocess model predictions, particularly for fermentation co-products; 2) Genome-scale metabolic flux modeling; 3) Development of metabolic engineering strategies through modeling; 4) Techniques for DNA manipulation and assembly along with genome editing; 5) Synthetic circuit design and pathway expression optimization; 6) 13C-based metabolic flux analysis; and 7) Optimizing a metabolic pathway during fermentation, considering reaction kinetics, thermodynamics, and fluid mechanics in a large scale fermenter. The workshop outcomes are also expected to have significant impact on the biofuels industry, particularly for biorefinery operations where both biofuels and valued co-products are made through fermentation processes.

多尺度代谢建模和工程研讨会将于2016年8月在弗吉尼亚州阿灵顿的弗吉尼亚理工大学国家首都地区（NCR）校园举行。 本次研讨会将把代谢工程的最新学术进展综合成对生物加工行业有用的和可翻译的信息。研讨会的参与者将是工业和学术研究人员的组合，他们被确定为生物工艺工程师，代谢工程师，蛋白质工程师和合成生物学家。代谢工程方法在工业发酵中的应用可以对药物、化学品和生物燃料的高效生产产生重大影响。研讨会将探讨如何更好地整合代谢工程原理和建模与工业生物过程工程模型，通过以下主题：1）使用SuperPRO Designer评估生物过程经济性，并评估代谢工程对改善和增强这些生物过程模型预测的影响，特别是对于发酵副产物; 2）基因组规模的代谢通量建模; 3）通过建模开发代谢工程策略; 4）DNA操作和组装沿着基因组编辑技术; 5）合成电路设计和途径表达优化; 6）基于13 C的代谢通量分析;和7）在大规模发酵罐中考虑反应动力学、热力学和流体力学，优化发酵期间的代谢途径。 预计研讨会的成果也将对生物燃料行业产生重大影响，特别是对通过发酵过程生产生物燃料和有价值的副产品的生物精炼业务。