Asymmetric ion-pair catalysis

近年来，不含金属的低分子量分子已成为强有力的催化剂，并已成功地应用于各种高对映选择性的转化。在迄今为止报道的不同催化领域中，离子对催化领域只是最近才发展成为一个重要的研究领域，并且已经实现了涉及亚胺和羰基活化的各种不对称反应。尽管已经取得了显著的进展，但强酸性催化剂催化的不对称反应的例子仍然很少。在这种情况下，我们计划合成新的手性强酸性催化剂，以实现非常有价值的不对称化学转化，迄今尚未实现。一个特别的重点将是针对手性离子对催化的概念，较低的碱性底物的活化和实际和有效的，传统上在金属催化下进行的对映选择性转化的发展。

In recent years metal free, low molecular weight molecules have emerged as powerful catalysts and have successfully been applied in various highly enantioselective transformations. Among the different areas of catalysis reported to date, the domain of ion-pair catalysis has only recently evolved as an important field of research and a variety of asymmetric reactions involving imine and carbonyl activations have been realized. Despite the significant advances made, examples of asymmetric reactions catalyzed by strongly acidic catalysts are still rare. In this context, we plan to synthesize new chiral strongly acidic catalysts for the realization of highly valuable asymmetric chemical transformations, which have not been achieved to date. A special focus will be directed to the concept of chiral ion-pair catalysis, the activation of less basic substrates and the development of practical and efficient, enantioselective transformations which are traditionally performed under metal catalysis.