Strongly acidic Brønsted acids as efficient catalysts in asymmetric synthesis

强酸性布朗斯台德酸作为不对称合成中的有效催化剂

• 批准号: 40485016
• 负责人: Professor Dr. Magnus Rüping
• 金额: --
• 依托单位: Division of Physical Science and Engineering
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2007
• 资助国家: 德国
• 起止时间: 2006-12-31 至 2012-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/40485016?language=en
• 关键词: Strongly; acidic; Br; nsted; acids

In recent years small organic molecules have been widely used as catalyst for enantioselective transfonmations. Inspired by nature most these organocatalysts have been considered as alternatives to enzymes with the advantage of being less expensive, more stable, readily available and showing a broader substrate scope as compared to their biological counterparts. The field of asymmetric organocatalysis has grown rapidly and can now be subdivided by the mechanism of activation into several reaction types, including enamine, iminium, carbene, hydrogen bonding and Brensted acid catalysis. Compared to the other activation mechanisms asymmetric Brønsted acid catalysis is still in its infancy. Therefore, we plan to synthesize new strongly acidic Brönsted acids for the development of new highly enantioselective transformations. A special focus will be directed to carbonyl activations and we hope to enable near to perfect reaction conditions in these reactions. This will not only help us to grow our understanding of the mechanisms at play, but would ideally bring us in the position of targeted catalyst and reaction design.

近年来，有机小分子作为催化剂被广泛应用于对映体选择性转化反应中。受自然界的启发，大多数这些有机催化剂被认为是酶的替代品，其优点是更便宜，更稳定，更容易获得，并且与其生物对应物相比显示出更广泛的底物范围。不对称有机催化领域发展迅速，现在可以根据活化机理细分为几种反应类型，包括烯胺，亚胺，卡宾，氢键和Brensted酸催化。与其他活化机制相比，不对称布朗斯特酸催化仍处于起步阶段。因此，我们计划合成新的强酸性布朗斯特酸，用于开发新的高对映选择性转化。一个特别的重点将是针对羰基活化，我们希望能够在这些反应中接近完美的反应条件。这不仅有助于我们加深对作用机制的理解，而且将理想地使我们处于目标催化剂和反应设计的位置。