CAREER: High-throughput Imaging of Drug Response in Tumor Organoids

职业：肿瘤类器官药物反应的高通量成像

• 批准号: 1642287
• 负责人: Melissa Skala
• 金额: $ 50.95万
• 依托单位: Morgridge Institute for Research, Inc.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-07-01 至 2021-04-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1642287&HistoricalAwards=false
• 关键词: CAREER; throughput; Imaging; Drug; Response

ABSTRACTPI: Scala, Melissa Proposal: 1554027The proposal focuses on developing a high-throughput imaging technology to measure drug response and cellular metabolism in tumor cells cultured with cells in their native environment. The data obtained will be used to predict tumor response to multiple drugs, providing information that can be used to optimize drug treatment for the individual cancer patient. The Educational Plan, which includes a new undergraduate course in optical imaging, has a strong emphasis on outreach activities directed at middle and high school students and girls.Interference light sheet Fourier Fluorescence lifetime imaging microscopy (iLS-FP-FLIM) will be created and information obtained by imaging NADH and FAD coenzymes in human breast cancer cells grown in a mouse model. This will be used to predict tumor response to multiple drugs, providing information that can be used to optimize drug treatment for the individual cancer patient.

AbstractPI：Scala，Melissa提案：1554027该提案着重于开发高通量成像技术，以测量用天然环境中用细胞培养的肿瘤细胞中的药物反应和细胞代谢。获得的数据将用于预测肿瘤对多种药物的反应，提供可用于优化个体癌症患者药物治疗的信息。 The Educational Plan, which includes a new undergraduate course in optical imaging, has a strong emphasis on outreach activities directed at middle and high school students and girls.Interference light sheet Fourier Fluorescence lifetime imaging microscopy (iLS-FP-FLIM) will be created and information obtained by imaging NADH and FAD coenzymes in human breast cancer cells grown in a mouse model.这将用于预测肿瘤对多种药物的反应，提供可用于优化个体癌症患者药物治疗的信息。