Variation in cardioviruses in rats and Microcebus griseorufus as a rodent-primate model for interspecific transmission of viruses

大鼠和灰鼠心脏病毒的变异作为病毒种间传播的啮齿动物-灵长类动物模型

• 批准号: 226350935
• 负责人: Professor Dr. Jörg U. Ganzhorn
• 金额: --
• 依托单位: Institut für Evolutionsökologie und Naturschutzgenomik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/226350935?language=en
• 关键词: Variation; cardioviruses; rats; Microcebus; griseorufus

The goal of this study is to analyse spatial and seasonal variation in cardioviruses and enteroviruses in rats (Rattus rattus) and the primate Microcebus griseorufus. In addition we investigate the evidence of direct acquisition of rodent viruses by primates, as well as the population patterns associated with it. Based on the spatial, temporal, and physiological pattern of the host organisms we will formulate hypotheses on the role of contact intensity for interspecific transmission of viruses. We expect that evidence for sporadic transmission, either by direct virus detection or by serology, will be detectable but that the maintenance of virus in primates, once acquired, will depend on further population-dependent parameters such as group density or specific physical conditions such as age and reproduction. The results of this rodent – primate model will also be of relevance for land use management for human health and conservation management to maintain endemic species.

本研究的目的是分析大鼠（Rattus rattus）和灵长类动物灰红微猴（Microcebus griseorufus）中心脏病毒和肠道病毒的空间和季节变化。此外，我们调查的证据，直接收购啮齿动物病毒的灵长类动物，以及与之相关的人口模式。基于空间，时间和生理模式的宿主生物，我们将制定假说的作用，接触强度的种间传播的病毒。我们预计，通过直接病毒检测或血清学检测，零星传播的证据将是可检测的，但病毒在灵长类动物中的维持，一旦获得，将取决于进一步的人口依赖性参数，如群体密度或特定的身体条件，如年龄和繁殖。这一啮齿动物-灵长类动物模型的结果也将与人类健康的土地使用管理和维护地方物种的保护管理有关。