Variation in cardioviruses in rats and Microcebus griseorufus as a rodent-primate model for interspecific transmission of viruses

大鼠和灰鼠心脏病毒的变异作为病毒种间传播的啮齿动物-灵长类动物模型

• 批准号: 226350935
• 负责人: Professor Dr. Jörg U. Ganzhorn
• 金额: --
• 依托单位: Institut für Evolutionsökologie und Naturschutzgenomik
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/226350935?language=en
• 关键词: Variation; cardioviruses; rats; Microcebus; griseorufus

The goal of this study is to analyse spatial and seasonal variation in cardioviruses and enteroviruses in rats (Rattus rattus) and the primate Microcebus griseorufus. In addition we investigate the evidence of direct acquisition of rodent viruses by primates, as well as the population patterns associated with it. Based on the spatial, temporal, and physiological pattern of the host organisms we will formulate hypotheses on the role of contact intensity for interspecific transmission of viruses. We expect that evidence for sporadic transmission, either by direct virus detection or by serology, will be detectable but that the maintenance of virus in primates, once acquired, will depend on further population-dependent parameters such as group density or specific physical conditions such as age and reproduction. The results of this rodent – primate model will also be of relevance for land use management for human health and conservation management to maintain endemic species.

这项研究的目的是分析大鼠（Rattus rattus）和灵长类动物Microcebus Griseorufus的心脏病毒和肠病毒的空间和季节变化。此外，我们研究了通过素数直接获得啮齿动物病毒的证据，以及与之相关的种群模式。基于宿主生物的空间，临时和物理模式，我们将提出关于接触强度在种间传播病毒的作用的假设。我们希望可以检测到偶发传播的证据，无论是通过直接病毒检测还是通过血清学检测，但是一旦获得的私人维持病毒的维持将取决于进一步的人群依赖性参数，例如群体密度或特定的身体状况，例如年龄和繁殖。这种啮齿动物的结果 - 私人模型也将与人类健康和保护管理的土地使用管理有关，以维持内在物种。