I-Corps: Biosensors for Accurate and Rapid Detection of Pathogens

I-Corps：用于准确快速检测病原体的生物传感器

• 批准号: 1644071
• 负责人: Mahmoud Almasri
• 金额: $ 5万
• 依托单位: University of Missouri-Columbia
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2018-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1644071&HistoricalAwards=false
• 关键词: Corps; Biosensors; Accurate; Rapid; Detection

The broader impact of this I-Corps project involves the rapid, simultaneous detection of multiple foodborne pathogens. This team's technology may have use in a broad range of applications in areas such as: food processing and distribution facilities, primary care clinics, clinical labs, contract labs, veterinary labs, pharmaceutical development markets, crop protection systems, and possible prevention of bioterrorism threats through contamination of water and food supplies. If successful, this technology will benefit USA market competitiveness in biosensor technology and will impact the economy though the protection of human health, food and water supplies, and prevention of product recalls. The information gathered through the I-Corps experience will enable refinement of the biosensing technology to address customers' needs. In addition, the entrepreneurial skills and knowledge gained through I-Corps will assist the project team to explore the commercial potential of this technology: an accurate, low cost, portable, user-friendly biosensor for onsite detection of multiple common Salmonella enterica serogroups that also captures samples for additional lab testing. The same device can be used for testing other pathogens such as Escherichia coli, Listeria, Campylobacter, and Vibrio. A noteworthy innovation of this team's prototype biosensor includes its ability to concentrate samples by removing over 70% of the volume of the testing media, and trapping and simultaneously detecting three to five pathogens within an hour. The biosensor has high selectivity and sensitivity of 10 CFU/ml.

I-Corps项目的更广泛影响涉及多种食源性病原体的快速、同时检测。该团队的技术可能在以下领域有广泛的应用：食品加工和分销设施、初级保健诊所、临床实验室、合同实验室、兽医实验室、药物开发市场、作物保护系统，以及可能通过水和食品供应污染预防生物恐怖主义威胁。如果成功，这项技术将有利于美国在生物传感器技术方面的市场竞争力，并将通过保护人类健康、食品和水供应以及防止产品召回，对经济产生影响。通过I-Corps经验收集的信息将使生物传感技术的改进能够满足客户的需求。此外，通过I-Corps获得的创业技能和知识将帮助项目团队探索这项技术的商业潜力：一种准确、低成本、便携式、用户友好的生物传感器，用于现场检测多种常见的肠道沙门氏菌血清群，也可以捕获样本进行额外的实验室测试。同样的设备也可用于检测其他病原体，如大肠杆菌、李斯特菌、弯曲杆菌和弧菌。该团队的原型生物传感器的一个值得注意的创新包括它能够通过去除超过70%的测试介质体积来浓缩样品，并在一小时内捕获并同时检测三到五种病原体。该生物传感器具有10 CFU/ml的高选择性和灵敏度。