Phenotypic profiling from DNA using genetic and epigenetic information

使用遗传和表观遗传信息进行 DNA 表型分析

• 批准号: DP160102400
• 负责人: Prof Peter Visscher
• 金额: $ 23.04万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP160102400
• 关键词: Phenotypic; profiling; DNA; using; genetic

The project intends to quantify how much information about a person can be inferred from a DNA sample. A DNA sample contains epigenomic information additional to the genome sequence. This information can reflect age and the past and present lifestyle of the individual whose sample it is. The project aims to quantify the accuracy of lifestyle and phenotypic prediction from DNA. Existing genome-wide genotype and methylation array data from thousands of blood samples from human subjects will be statistically analysed to develop and validate predictors for chronological age, smoking, caffeine use, pesticide exposure, diet and body mass index. Potential applications of epigenomic prediction are widespread, ranging from forensics to ecology.

该项目旨在量化从DNA样本中可以推断出多少关于一个人的信息。DNA样本除了包含基因组序列外，还包含表观基因组信息。这些信息可以反映样本个体的年龄以及过去和现在的生活方式。该项目旨在量化DNA对生活方式和表型预测的准确性。现有的全基因组基因型和甲基化阵列数据来自数千名人类受试者的血液样本，将进行统计分析，以开发和验证实足年龄、吸烟、咖啡因使用、农药暴露、饮食和体重指数的预测因子。表观基因组预测的潜在应用是广泛的，从法医学到生态学。