SBIR Phase I: Development of an electrochemical C-C bond forming reaction

该SBIR一期项目建议开发一种新的电化学方法，用于制造制药、农业和精细化学品生产商感兴趣的化学品。需要新的化学品制造技术来降低传统化学品制造技术带来的环境成本和风险。流动技术正在减少药物生产的危害、环境影响和成本，同时提供改进的产品。该项目将开发利用流动技术操作的新化学品。为了充分实现流动技术的效益，开发这种新型反应是必要的。此外，为了加快这种先进制造技术的发展，研究实验室的新设备也是必要的。NSF在先进制造技术开发方面的投资，如SBIR一期项目，将对美国经济产生广泛的影响。这项技术有望降低生产药品和材料的成本。这项提议使化学品的使用点生产成为可能，从而有可能消除运输、储存和处理危险材料的需要。像这个项目这样的先进化学制造技术的发展对美国制造商来说将是一个战略优势，使他们能够利用这个项目这样的高效技术创造新的高价值分子。SBIR一期项目旨在开发一种电化学介导的反应，使用流动化学作为实用、安全和可持续的手段，在高价值化学品和材料的制造中取代危险和对环境有害的催化剂和试剂。碳-碳键形成反应对药品和材料的商业化生产至关重要。这些反应通常使用高活性的有机金属反应物与贵金属催化结合形成键。这个SBIR项目旨在开发一个电化学的sp2-sp3成键反应。该项目将使用Kolbe电解反应生成sp3自由基，该自由基将在镍催化剂的存在下与芳基或乙烯基卤化物反应，用于激活sp2-卤化物键。在电化学流动电池中，电将被用来氧化羧酸盐和还原镍催化剂。作为一种流动工艺，这种方法将很容易适用于商业规模生产。为了促进反应的发展，该项目还将开发一个最佳的实验室规模的电化学流动电池。该项目的目标是开发一种更有效的sp2-sp3键形成方法，并开发合适的实验室工具，使其他研究人员能够轻松采用和使用新的反应类型。

This SBIR Phase I project is proposing the development of a new electrochemical method for the manufacture of chemicals of interest to pharmaceutical, agricultural and fine chemical producers. New chemical manufacturing technologies are needed to reduce the environmental costs and the risk posed by traditional chemical manufacturing technologies. Flow technology is reducing the hazard, environmental impact and cost of drug manufacture while at the same time providing an improved product. This project will develop new chemistries designed to operate using flow technology. The development of such new reactions is necessary to realize the full benefit of flow technology. Further, new equipment for the research laboratory is also necessary to speed the development of this advanced manufacturing technology. NSF investment in the development of advance manufacturing technology like this SBIR Phase I project will have widespread impact on the US economy. The technology promises to lower the cost of producing medicines and materials. The point-of-use production of chemicals enabled by this proposal has the potential to eliminate the need to ship, store and handles hazardous materials. The development of advanced chemical manufacturing technologies such as this project will be a strategic advantage to US manufacturers enabling the creation of new high value molecules using the highly efficient technologies such as this project.This SBIR Phase I project is aimed at the development of an electrochemically-mediated reaction using flow chemistry as practical, safe and sustainable means of replacing hazardous and environmentally damaging catalysts and reagents in the manufacture of high-value chemicals and materials. Carbon-carbon bond forming reactions are of critical importance to the commercial production of medicines and materials. These reactions typically use of highly reactive organometallic reactants in combination with precious metal catalysis to form the bond. This SBIR project is aimed at developing an electrochemical sp2-sp3 bond forming reaction. The project will use the Kolbe electrolysis reaction to generate sp3 radicals which will react with an aryl or vinyl halide in the presence of a nickel catalyst used to activate a sp2-halide bond. Electricity will be used to both oxidize the carboxylates and reduce the nickel catalyst in an electrochemical flow-cell. Developed as a flow process, this method will be readily applicable to commercial scale production. To facilitate development of the reaction the project will also develop an optimal lab-scale electrochemical flow cell. The project goal is to both develop both a more efficient method for sp2-sp3 bond forming and also develop appropriate lab tools to enable other researchers to easily adopt and use the new reaction types.