SBIR Phase I: Development of an electrochemical C-C bond forming reaction

SBIR 第一阶段：电化学 C-C 键形成反应的开发

• 批准号: 1645765
• 负责人: Matthew Bio
• 金额: $ 22.46万
• 依托单位: Snapdragon Chemistry Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-09-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1645765&HistoricalAwards=false
• 关键词: SBIR; Phase; Development; electrochemical; bond

This SBIR Phase I project is proposing the development of a new electrochemical method for the manufacture of chemicals of interest to pharmaceutical, agricultural and fine chemical producers. New chemical manufacturing technologies are needed to reduce the environmental costs and the risk posed by traditional chemical manufacturing technologies. Flow technology is reducing the hazard, environmental impact and cost of drug manufacture while at the same time providing an improved product. This project will develop new chemistries designed to operate using flow technology. The development of such new reactions is necessary to realize the full benefit of flow technology. Further, new equipment for the research laboratory is also necessary to speed the development of this advanced manufacturing technology. NSF investment in the development of advance manufacturing technology like this SBIR Phase I project will have widespread impact on the US economy. The technology promises to lower the cost of producing medicines and materials. The point-of-use production of chemicals enabled by this proposal has the potential to eliminate the need to ship, store and handles hazardous materials. The development of advanced chemical manufacturing technologies such as this project will be a strategic advantage to US manufacturers enabling the creation of new high value molecules using the highly efficient technologies such as this project.This SBIR Phase I project is aimed at the development of an electrochemically-mediated reaction using flow chemistry as practical, safe and sustainable means of replacing hazardous and environmentally damaging catalysts and reagents in the manufacture of high-value chemicals and materials. Carbon-carbon bond forming reactions are of critical importance to the commercial production of medicines and materials. These reactions typically use of highly reactive organometallic reactants in combination with precious metal catalysis to form the bond. This SBIR project is aimed at developing an electrochemical sp2-sp3 bond forming reaction. The project will use the Kolbe electrolysis reaction to generate sp3 radicals which will react with an aryl or vinyl halide in the presence of a nickel catalyst used to activate a sp2-halide bond. Electricity will be used to both oxidize the carboxylates and reduce the nickel catalyst in an electrochemical flow-cell. Developed as a flow process, this method will be readily applicable to commercial scale production. To facilitate development of the reaction the project will also develop an optimal lab-scale electrochemical flow cell. The project goal is to both develop both a more efficient method for sp2-sp3 bond forming and also develop appropriate lab tools to enable other researchers to easily adopt and use the new reaction types.

SBIR 第一阶段项目提议开发一种新的电化学方法，用于制造制药、农业和精细化学品生产商感兴趣的化学品。需要新的化学制造技术来降低环境成本和传统化学制造技术带来的风险。流程技术正在减少药品生产的危害、环境影响和成本，同时提供改进的产品。该项目将开发新的化学物质，旨在使用流动技术进行操作。为了充分发挥流动技术的优势，开发此类新反应是必要的。此外，还需要研究实验室的新设备来加速这种先进制造技术的发展。 NSF 对先进制造技术开发（如 SBIR 第一期项目）的投资将对美国经济产生广泛影响。该技术有望降低药品和材料的生产成本。该提案所支持的化学品的使用点生产有可能消除运输、储存和处理危险材料的需要。像这个项目这样的先进化学制造技术的开发对于美国制造商来说将是一个战略优势，能够利用像这个项目这样的高效技术来创造新的高价值分子。这个SBIR第一阶段项目的目的是开发一种电化学介导的反应，使用流动化学作为实用、安全和可持续的手段来替代制造过程中危险和环境破坏的催化剂和试剂。 高价值化学品和材料。碳-碳键形成反应对于药物和材料的商业生产至关重要。这些反应通常使用高反应性有机金属反应物与贵金属催化相结合来形成键。该 SBIR 项目旨在开发电化学 sp2-sp3 键形成反应。该项目将利用 Kolbe 电解反应生成 sp3 自由基，该自由基将在用于激活 sp2-卤化物键的镍催化剂存在下与芳基或乙烯基卤化物发生反应。电将用于氧化羧酸盐并还原电化学流通池中的镍催化剂。作为流程开发，该方法将很容易适用于商业规模生产。为了促进反应的发展，该项目还将开发一种最佳的实验室规模电化学流动池。该项目的目标是开发一种更有效的 sp2-sp3 键形成方法，并开发适当的实验室工具，使其他研究人员能够轻松采用和使用新的反应类型。