I-Corps: System of Multimodal Imaging and Point-of-Care Biopsies

I-Corps：多模态成像和床旁活检系统

• 批准号: 1648553
• 负责人: Barbara Smith
• 金额: $ 5万
• 依托单位: Arizona State University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2018-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1648553&HistoricalAwards=false
• 关键词: Corps; System; Multimodal; Imaging; Point

The broader impact/commercial potential of this I-Corps project is that it may potentially impact the lives of millions of women worldwide who are tested for the presence of endometrial cancer. In the US, women who with abnormal vaginal bleeding (regardless of age, shape, race, economic standing, history or ethnicity) are considered to have endometrial cancer, until proven otherwise. Unfortunately, unlike the use of pap tests for the detection of cervical cancer, no tests or exams currently exist for screening endometrial cancer. Simple and accurate screening and biopsy tools are important for the early detection of endometrial cancer because of: i) clinical requirements to rule out cancer first and foremost, ii) improved survival rates with early detection, and iii) high pain, cost, and time associated with current diagnostic measures. This team's process may enable women to get access to non-invasive, accurate diagnoses of endometrial cancer not otherwise available. Accurate, real time and early diagnosis of endometrial cancer will benefit and estimated one out of nineteen women.This I-Corps project focuses on the first steps in translating a miniaturized tool for discerning healthy vs. malignant tissue at the point of care. Despite the critical need, no method currently exists for the real time, clinical diagnosis of endometrial cancer. Current methods require a succession of inconclusive, invasive, and time-consuming tests, thus failing to meet the needs of the user. To fill this gap, this projects aims to develop a product for screening endometrial cancer during the first visit to a clinic. Two imaging modalities are integrated, including photoacoustic imaging (known to provide a clear map of vasculature, and ultrasound) for deep tissue penetration, identifying tissue density. This combination will enable the detection of tissue not otherwise able to be reached without expensive and invasive procedures requiring contrast agents. This new method of device manipulation will allow for complete 3D imaging of an organ, in conjunction with tissue sample collection.

这个I-Corps项目更广泛的影响/商业潜力是，它可能会影响全球数百万接受子宫内膜癌检测的妇女的生活。在美国，阴道异常出血的女性（无论年龄，形状，种族，经济地位，历史或种族）都被认为患有子宫内膜癌，直到证明不是这样。不幸的是，与使用巴氏试验检测宫颈癌不同，目前没有用于筛查子宫内膜癌的测试或检查。简单而准确的筛查和活检工具对于子宫内膜癌的早期检测很重要，因为：i）首先排除癌症的临床要求，ii）早期检测提高了生存率，iii）与当前诊断措施相关的高疼痛，成本和时间。该团队的过程可能使妇女能够获得非侵入性的，准确的子宫内膜癌诊断，否则无法获得。 准确，真实的时间和子宫内膜癌的早期诊断将受益，估计十九分之一的妇女。这个I-Corps项目的重点是在翻译一个微型工具的第一步，用于区分健康与恶性组织在护理点。尽管迫切需要，但目前还不存在用于子宫内膜癌的真实的临床诊断的方法。目前的方法需要一系列不确定的、侵入性的和耗时的测试，因此不能满足用户的需求。为了填补这一空白，该项目旨在开发一种产品，用于在首次就诊时筛查子宫内膜癌。 集成了两种成像模式，包括用于深层组织穿透的光声成像（已知可提供清晰的脉管系统图和超声），以识别组织密度。这种组合将使得能够检测组织，否则在没有需要造影剂的昂贵和侵入性程序的情况下无法到达。这种新的设备操作方法将允许对器官进行完整的3D成像，并结合组织样本收集。