STTR Phase I: XERICO-Mediated Drought Tolerance Technology
STTR第一期:XERICO介导的耐旱技术
基本信息
- 批准号:1648805
- 负责人:
- 金额:$ 22.48万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-12-15 至 2018-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is the development of drought-tolerant crops through biotechnology, which is potentially both economically and environmentally important. Genetic engineering of drought tolerance has been very recalcitrant because of the complexity of plant responses to water stress. The proposed technology offers novel features to overcome the current limitations. Commercial deployment of this technology will improve significantly the profitability of growers and seed companies, and will benefit society by enabling crop production on arid lands. The primary target market is the genetically engineered corn seed industry. A significant market opportunity is present if corn can be modified to express drought tolerance. Corn is the second most plentiful cereal grown for human consumption and animal feeds, and accounts for over 43% of the $47 billion global seed market. The commercial strategy will be to penetrate the market by partnering with the major corn seed companies as well as mid-size seed companies with expertise in breeding, commercial seed production, marketing, and sales.This STTR Phase I project proposes to develop a proprietary and potentially transformative technology to increase drought tolerance in plants. It utilizes a plant's natural response system to better protect it from drought stress. This drought tolerance mechanism is employed in a highly drought-specific manner to avoid the growth penalty often observed with drought tolerance technologies. In addition, this drought tolerance is achieved with limited perturbation of other biological processes in the plants. Until its effectiveness is validated under field conditions, the technical risk of the technology remains very high and engaging potential industry partners likely will be difficult. The goal of this project is to obtain the field verification data that is needed to decrease the technical risk, thus making it attractive to potential licensing partners. The company will reach the goal by achieving two specific objectives: 1) Identification and selection of transgenic lines that show strong drought tolerance under greenhouse conditions, and 2) Conducting field tests to validate the greenhouse performance. Successful completion of this project would enable the company to have a broad licensing strategy directed towards corn seed companies for commercialization.
这项小型企业技术转让项目的更广泛影响/商业潜力是通过生物技术开发耐旱作物,这在经济和环境方面都可能具有重要意义。由于植物对水分胁迫反应的复杂性,抗旱基因工程一直非常困难。提出的技术提供了克服当前限制的新特性。这项技术的商业化部署将大大提高种植者和种子公司的盈利能力,并将通过在干旱土地上实现作物生产而造福社会。主要目标市场是转基因玉米种子产业。如果玉米能被改造成具有耐旱性,就会有很大的市场机会。玉米是供人类食用和动物饲料的第二大谷物,占全球470亿美元种子市场的43%以上。商业战略将是通过与主要玉米种子公司以及在育种、商业种子生产、营销和销售方面具有专业知识的中型种子公司合作来渗透市场。这个STTR一期项目建议开发一种专有的和潜在的变革性技术来提高植物的抗旱性。它利用植物的自然反应系统来更好地保护植物免受干旱压力。这种抗旱机制以一种高度干旱特异性的方式被采用,以避免抗旱技术经常观察到的生长惩罚。此外,这种耐旱性是在植物中其他生物过程的有限扰动下实现的。在其有效性在现场条件下得到验证之前,该技术的技术风险仍然很高,并且很难吸引潜在的行业合作伙伴。该项目的目标是获得减少技术风险所需的现场验证数据,从而使其对潜在的许可合作伙伴具有吸引力。该公司将通过实现两个具体目标来实现这一目标:1)鉴定和选择在温室条件下表现出强耐旱性的转基因品系;2)进行田间试验以验证温室性能。该项目的成功完成将使该公司能够针对玉米种子公司的商业化制定广泛的许可战略。
项目成果
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