Doctoral Dissertation Research: Quantitative genetics of sexual dimorphism in primate teeth

博士论文研究：灵长类动物牙齿两性二态性的定量遗传学

• 批准号: 1650802
• 负责人: Kieran McNulty
• 金额: $ 1.63万
• 依托单位: University of Minnesota-Twin Cities
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-03-01 至 2017-11-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1650802&HistoricalAwards=false
• 关键词: Doctoral; Dissertation; Research; Quantitative; genetics

Many nonhuman primate species have sex differences in the size and shape of their canine and premolar teeth, but in the human lineage those differences are smaller. This project models the genetic inheritance of canine and premolar tooth size in several primate species, including a modern human sample, to examine the impact of genetic structures on the evolution of sex differences in canine size. The findings will be used to understand mechanisms of canine reduction in the human lineage and canine expansion in other primates, and contribute to our understanding of evolutionary relationships among diet, behavior, and dentition in our hominin ancestors. elective pressures related to aggression and diet are hypothesized to contribute to sex differences in primate canine teeth, and changes in these selective pressures may have led to human canine and premolar reduction. The project will support training of a female student in a STEM field, production of a large dataset that will be made public for other researchers, and outreach activities such as public lectures focused on improving public understanding of primate diversity and evolution.Dental characteristics provide valuable evidence of genetic relatedness in primates, and tooth measurements are well-suited to classical quantitative genetic analysis, which uses pedigree data to estimate the genetic heritability of traits. This project assesses the genetic inheritance of canine and premolar dimensions in several primate species with the specific aim of elucidating the genetic mechanisms underlying sex differences in the morphology of these teeth. Previous researchers have stated that sex differences in genetic inheritance and low overlap in male and female genetic material contribute to the evolution of sex differences, but these hypotheses have not been tested in primates. This project addresses three fundamental research questions: 1) Are sex differences in canine and premolar size associated with sex differences in trait inheritance? 2) Do the same genes impact the size of the upper canine and lower premolar? 3) Do primate species with sex differences in the canine have more evolvable canines than those with no sex differences? These questions can be answered using tooth size measurements collected from primate populations with known pedigrees. Statistical models will be used to estimate the inheritance of canine and premolar size in each population. Preliminary data collection and analyses of saddle-back tamarins indicate that there are significant differences between male and female patterns of trait inheritance, but data from additional populations and species will demonstrate whether this is typical of primates broadly or a peculiarity limited to a single tamarin population.

许多非人类灵长类物种在犬齿和前臼齿的大小和形状上存在性别差异，但在人类谱系中，这些差异较小。该项目模拟了几种灵长类动物（包括现代人类样本）中犬齿和前臼齿大小的遗传遗传，以研究遗传结构对犬齿大小性别差异进化的影响。这些发现将用于了解人类谱系中犬齿减少和其他灵长类动物犬齿扩张的机制，并有助于我们理解人类祖先中饮食，行为和齿系之间的进化关系。与攻击和饮食有关的选择性压力被假设为导致灵长类犬齿的性别差异，这些选择性压力的变化可能导致人类犬齿和前磨牙的减少。该项目将支持在STEM领域培训一名女学生，制作一个大型数据集，向其他研究人员公开，并开展外联活动，如公开讲座，重点是提高公众对灵长类动物多样性和进化的理解。牙齿特征为灵长类动物的遗传相关性提供了有价值的证据，牙齿测量非常适合经典的定量遗传分析，它使用系谱数据来估计性状的遗传力。该项目评估了几种灵长类动物犬齿和前磨牙尺寸的遗传遗传，具体目的是阐明这些牙齿形态性别差异的遗传机制。以前的研究人员已经指出，遗传遗传中的性别差异和男性和女性遗传物质的低重叠有助于性别差异的进化，但这些假设尚未在灵长类动物中得到验证。该项目解决了三个基本研究问题：1）犬齿和前磨牙大小的性别差异是否与性状遗传的性别差异有关？2)相同的基因影响上犬齿和下前臼齿的大小吗？3)有犬齿性别差异的灵长类物种是否比没有性别差异的物种有更容易进化的犬齿？这些问题可以通过从已知谱系的灵长类种群中收集的牙齿大小测量来回答。将使用统计模型来估计每个群体中犬齿和前磨牙大小的遗传。 对鞍背绢毛猴的初步数据收集和分析表明，雄性和雌性之间的性状遗传模式存在显着差异，但来自其他种群和物种的数据将证明这是否是灵长类动物的典型特征或仅限于单个绢毛猴种群的特殊性。