CAREER: Numerical Methods and Computational Infrastructure for Simulating Prosthetic Heart Valve Function and Dysfunction

职业：模拟人工心脏瓣膜功能和功能障碍的数值方法和计算基础设施

• 批准号: 1652541
• 负责人: Boyce Griffith
• 金额: $ 50万
• 依托单位: University of North Carolina at Chapel Hill
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2023-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1652541&HistoricalAwards=false
• 关键词: CAREER; Numerical; Methods; Computational; Infrastructure

This project will advance mathematical methods and computational software for simulating the dynamics of prosthetic heart valves. In the United States, heart valve diseases affect approximately 8.5% of the population aged 65 to 74 years, and approximately 13.3% of those aged 75 years or older. Treatment for severe aortic valve disease is generally to replace the heart valve with a mechanical or bioprosthetic valve, and approximately 70,000 aortic valve replacements are performed in the U.S. each year. Bioprosthetic heart valves (BHVs) degrade over time, however, and these devices have a typical durable lifetime of only 10-15 years. To date, there have been relatively few studies on modeling BHV fatigue, and there are no predictive models of BHV failure. The methods created in this project can yield advanced fluid-structure interaction (FSI) models of heart valve function as well as the first FSI modeling tools for simulating BHV valve failure. By advancing broadly applicable FSI modeling technologies and their specific application to heart valve dynamics, the project aligns with NFS's mission of promoting the progress of science and advancing national health.This project will integrate higher-order immersed boundary (IB) methods, peridynamics, and turbulence modeling to predict prosthetic heart valve function and dysfunction (fatigue and failure). The project will advance cardiovascular FSI simulation accuracy by developing and analyzing two classes of sharp-interface immersed boundary (IB) methods capable of using experimentally constrained elasticity models with complex, three-dimensional geometries and integrating large-eddy simulation (LES) turbulence models with these new FSI methods. This project also aims to develop new FSI methods for simulating tissue failure by integrating IB methods with peridynamics, which is a nonlocal formulation of solid mechanics that is well suited for modeling structural failure. These models will be validated using experimental data obtained in ongoing studies at the FDA Heart Valve Lab. These methods will be implemented within the open-source IBAMR software, which is used by many independent research groups in a broad range of fields. This project also integrates research aims with an educational plan leverages UNC's outstanding high-performance computing environment, experimental facilities available to UNC's applied math group, and UNC's major new makerspace initiative, BeAM (Be a Maker). Finally, research and educational products of this project will be incorporated into ongoing activities at UNC's main science outreach unit, the Morehead Planetarium & Science Center.

该项目将推进模拟人工心脏瓣膜动力学的数学方法和计算软件。 在美国，心脏瓣膜疾病影响约8.5%的65 - 74岁人群，约13.3%的75岁或以上人群。 严重主动脉瓣疾病的治疗通常是用机械或生物瓣膜置换心脏瓣膜，每年在美国进行约70，000例主动脉瓣置换术。 然而，生物人工心脏瓣膜（BHV）会随着时间的推移而降解，这些器械的典型耐用寿命仅为10-15年。 到目前为止，已经有相对较少的研究建模BHV疲劳，也没有预测模型的BHV故障。 该项目中创建的方法可以产生心脏瓣膜功能的先进流体-结构相互作用（FSI）模型以及用于模拟BHV瓣膜失效的第一个FSI建模工具。 通过推进广泛适用的FSI建模技术及其在心脏瓣膜动力学中的具体应用，该项目符合NFS促进科学进步和促进国民健康的使命。该项目将集成高阶浸没边界（IB）方法、周期运动学和湍流建模，以预测人工心脏瓣膜功能和功能障碍（疲劳和失效）。 该项目将通过开发和分析两类尖锐界面浸没边界（IB）方法来提高心血管FSI模拟的准确性，这些方法能够使用具有复杂三维几何形状的实验约束弹性模型，并将大涡模拟（LES）湍流模型与这些新的FSI方法相结合。 该项目还旨在开发新的FSI方法，通过将IB方法与周向力学相结合来模拟组织失效，周向力学是固体力学的非局部公式，非常适合于建模结构失效。 将使用FDA心脏瓣膜实验室正在进行的研究中获得的实验数据对这些模型进行确认。 这些方法将在开源IBAMR软件中实现，该软件被许多独立研究小组在广泛的领域中使用。 该项目还将研究目标与教育计划相结合，利用了英特尔卓越的高性能计算环境、英特尔应用数学小组可用的实验设施以及英特尔主要的新创客空间倡议BeAM（Be a Maker）。 最后，该项目的研究和教育产品将被纳入正在进行的活动，在该中心的主要科学推广单位，莫尔黑德天文馆科学中心。

项目成果

An immersed interface-lattice Boltzmann method for fluid-structure interaction

• DOI: 10.1016/j.jcp.2020.109807
• 发表时间: 2020-03
• 期刊: ArXiv
• 作者: J. Qin;E. M. Kolahdouz;Boyce E. Griffith

A sharp interface Lagrangian-Eulerian method for flexible-body fluid-structure interaction

柔性体液-结构相互作用的锐界面拉格朗日-欧拉方法

• DOI: 10.1016/j.jcp.2023.112174
• 发表时间: 2023
• 期刊: Journal of Computational Physics
• 影响因子: 4.1
• 作者: Kolahdouz, Ebrahim M.;Wells, David R.;Rossi, Simone;Aycock, Kenneth I.;Craven, Brent A.;Griffith, Boyce E.
• 通讯作者: Griffith, Boyce E.

The smooth forcing extension method: A high-order technique for solving elliptic equations on complex domains

平滑力扩展法：求解复杂域上椭圆方程的高阶技术

• DOI: 10.1016/j.jcp.2021.110390
• 发表时间: 2021
• 期刊: Journal of Computational Physics
• 影响因子: 4.1
• 作者: Qadeer, Saad;Griffith, Boyce E.
• 通讯作者: Griffith, Boyce E.

An immersed peridynamics model of fluid-structure interaction accounting for material damage and failure

• DOI: 10.1016/j.jcp.2023.112466
• 发表时间: 2023-09-20
• 期刊: JOURNAL OF COMPUTATIONAL PHYSICS
• 影响因子: 4.1
• 作者: Kim，Keon Ho;Bhalla，Amneet P. S.;Griffith，Boyce E.
• 通讯作者: Griffith，Boyce E.

An immersed interface method for discrete surfaces

• DOI: 10.1016/j.jcp.2019.07.052
• 发表时间: 2020-01-01
• 期刊: JOURNAL OF COMPUTATIONAL PHYSICS
• 影响因子: 4.1
• 作者: Kolahdouz, Ebrahim M.;Bhalla, Amneet Pal Singh;Griffith, Boyce E.
• 通讯作者: Griffith, Boyce E.