New Recyclable Phosphorous Ligands for Regio- and Stereocontrol in Homogeneous Catalysis

用于均相催化区域和立体控制的新型可回收磷配体

• 批准号: 22730784
• 负责人: Professor Dr. Peter Eilbracht
• 金额: --
• 依托单位: Forschungsgebiet Organische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2006
• 资助国家: 德国
• 起止时间: 2005-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/22730784?language=en
• 关键词: New; Recyclable; Phosphorous; Ligands; Regio

Multi-component and multi-step conversions as one-pot reaction sequences are attractive tools in modern synthetic chemistry. Many of these methods require multifunctional homogeneous catalysts. Immobilization of homogeneous catalysts on supports overcomes the inherent problems of separation and reuse. The project aims at development of novel immobilized ligand systems for homogeneous catalysis in membrane reactors. Immobilization is achieved with soluble, (ultra)filterable and reusable dendritic polyglycerols and the construction of functional shells. Applications of these systems for proof of principle is first tested with some achiral and chiral standard ligands. New convergent dendrimer and dendron syntheses are planned via combinations of acrylonitrile Michael addition/nitrile reduction sequences (Vögtle method) with hydroformylation/reductive amination (hydroaminomethylation). Endcapping of the dendrons with P or N/O functionalities including enantiomerically pure systems supplies the ligands for catalyst immobilization. Furthermore synthesis, catalytic evaluation of new P chirogenic systems is planned as well as their immobilization to dendritic polyglycerols and polyamines according to the above mentioned methods. The new immobilized ligands are to be tested in membrane reactors or similar flow systems for continuous production or library syntheses via homogeneous catalysis in order to realize new sustainable processes.

作为一锅反应序列的多组分和多步骤转化是现代合成化学中有吸引力的工具。许多这些方法需要多功能均相催化剂。将均相催化剂固定在载体上克服了分离和再利用的固有问题。该项目旨在开发用于膜反应器均相催化的新型固定配体系统。固定化是通过可溶、（超）过滤和可重复使用的树枝状聚甘油和功能性壳的构建来实现的。首先使用一些非手性和手性标准配体测试这些系统的原理证明应用。计划通过丙烯腈迈克尔加成/腈还原序列（Vögtle 方法）与加氢甲酰化/还原胺化（氢氨甲基化）的组合来合成新的聚合树枝状聚合物和树枝状大分子。 用 P 或 N/O 官能团（包括对映体纯系统）对树枝进行封端，为催化剂固定化提供配体。此外，还计划根据上述方法合成、催化评估新的 P 手性系统以及将其固定在树枝状聚甘油和多胺上。新的固定化配体将在膜反应器或类似的流动系统中进行测试，以通过均相催化进行连续生产或库合成，以实现新的可持续工艺。