I-Corps: Milli-electrode Array as Next Generation Profiling Technology for Biochemical Reaction Systems

I-Corps：毫电极阵列作为生化反应系统的下一代分析技术

• 批准号: 1655451
• 负责人: Baikun Li
• 金额: $ 5万
• 依托单位: University of Connecticut
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-12-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1655451&HistoricalAwards=false
• 关键词: Corps; Milli; electrode; Array; Next

The broader impact/commercial potential of this I-Corps project is to apply the compelling features "heterogeneity profiling" and "high spatial and temporal resolution" of the newly developed all-in-one milli-electrode array to solve the urgent need of real-time monitoring in a broad spectrum of biochemical reaction systems ranging from water/wastewater treatment units to food/pharmaceutical biofermentors. The commercialization of milli-electrode array as a new class of real-time in situ profiling technology will have substantial impacts on biochemical system market, specifically to obtain "head-to-toe" profiling and visualize biochemical heterogeneity, which will fundamentally change system monitoring and control, and optimize system operation at the lowest capital cost. The I-Corps funding will enable the team to establish a better understanding of biochemical system market and the needs of consumers, and thereby, maximizing the commercial success of this novel sensing technology.This I-Corps project aims at determining the commercial potential of milli-electrode array technology and exploring the customer needs. Currently, all the biochemical waste treatment (e.g. municipal wastewater, food waste, and industrial wastewater) systems are monitored using single point probes without obtaining a whole picture of system heterogeneity. With over 15,000 wastewater treatment plants to be retrofitted and 11,000 anaerobic digestion systems to be developed in the US by 2035, durable inexpensive rapid sensing device capable of simultaneously monitoring multiple parameters is of great significance to achieve high treatment efficiency and operational stability at lowest energy consumption, and thus yielding enormous social, environmental, and economic value. The innovation of the core milli-electrode array technology lies in precise patterning multiple types of mm-sized electrodes on a single flexible film and the capability of real-time profiling multiple biochemical parameters at high spatiotemporal resolution. The state of the art milli-electrode array possesses breakthrough properties compared to existing single-point sensors: sturdy configuration with long lifetime, simple measurement procedure, low cost, highly durable material, easy deployment and replacement, and profiling multiple parameters spatiotemporally.

这个I-Corps项目的更广泛的影响/商业潜力是应用新开发的一体化毫微米电极阵列的引人注目的特性“异质性分析”和“高时空分辨率”，以解决从水/废水处理装置到食品/制药生物发酵的广泛生化反应系统中实时监测的迫切需求。毫微米电极阵列作为一种新型的实时原位分析技术的商业化将对生化系统市场产生重大影响，特别是获得“从头到脚”的分析和可视化生化异质性，这将从根本上改变系统监测和控制，并以最低的资本成本优化系统运行。I-Corps的资金将使该团队能够更好地了解生化系统市场和消费者的需求，从而最大限度地提高这种新型传感技术的商业成功。这个I-Corps项目旨在确定毫微米电极阵列技术的商业潜力，并探索客户需求。目前，所有的生物化学废物处理（如城市污水、食物垃圾和工业废水）系统都是使用单点探针进行监测的，没有获得系统异质性的全貌。到2035年，美国将有超过15,000个污水处理厂进行改造，并开发11,000个厌氧消化系统，能够同时监测多个参数的耐用廉价快速传感设备对于以最低的能耗实现高处理效率和运行稳定性具有重要意义，从而产生巨大的社会，环境和经济价值。毫米电极阵列技术的核心创新在于在单一柔性薄膜上精确绘制多种毫米尺寸的电极，以及在高时空分辨率下实时分析多种生化参数的能力。与现有的单点传感器相比，最先进的毫极阵列具有突破性的特性：坚固的配置，长寿命，简单的测量程序，低成本，高度耐用的材料，易于部署和更换，并且可以在时空上分析多个参数。