Individual differences in endogenous oxytocin govern social cognition

内源性催产素的个体差异控制社会认知

• 批准号: 1657726
• 负责人: James Morris
• 金额: $ 49.98万
• 依托单位: University of Virginia Main Campus
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-02-01 至 2022-01-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1657726&HistoricalAwards=false
• 关键词: Individual; differences; endogenous; oxytocin; govern

Oxytocin is a hormone that plays a critical role in many social behaviors. Prior research suggests that natural variability in the oxytocin system affects neural systems involved in social cognition. This proposal examines whether more efficient oxytocin utilization increases sensitivity to social information. Increased sensitivity may confer an advantage when social information is relevant but may be disadvantageous in other contexts. Findings from this project are expected to provide new information about how people who differ in the way their neural systems are sensitized by this hormone respond to social information. The results will be broadly applicable to multiple disciplines spanning molecular, neural, and behavioral investigations, and may inspire new research in these disciplines. The experiments conducted are expected to provide valuable research opportunities and unique training combining molecular genetics and functional neuroimaging for students interested in psychology, cognitive science, and neurosciences. Oxytocin receptors (OXTR) allow the body to respond to oxytocin, but its expression differs between people. These receptors are under epigenetic control, specifically through DNA methylation, which is at least in part responsible for these individual differences. OXTR methylation has been associated with brain activity supporting social cognition and with various social phenotypes in both healthy and disordered populations. Combing this reliable, endogenous epigenetic marker with functional magnetic imaging and behavioral testing, this proposal tests the hypothesis that the endogenous oxytocin system influences the degree to which an individual is sensitive to social information. Its main aims are (1) to test whether variability in OXTR methylation is associated with differential engagement of perceptual and attentional systems during social information processing; (2) to evaluate whether individuals low in OXTR methylation depend on prefrontal brain systems to suppress irrelevant social information; and (3) to assess whether the relationship between OXTR methylation and neural systems supporting attention to social information predicts self-reported sociality and independently rated social skill.

催产素是一种荷尔蒙，在许多社会行为中起着关键作用。先前的研究表明，催产素系统中的自然变异性会影响参与社会认知的神经系统。这项建议调查了催产素的更有效利用是否增加了对社会信息的敏感性。当社会信息相关时，提高敏感度可能会带来好处，但在其他情况下可能会不利。这个项目的发现有望提供新的信息，说明神经系统对这种激素敏感的方式不同的人是如何对社会信息做出反应的。这些结果将广泛适用于跨越分子、神经和行为调查的多个学科，并可能启发这些学科的新研究。这些实验有望为对心理学、认知科学和神经科学感兴趣的学生提供宝贵的研究机会和结合分子遗传学和功能神经成像的独特培训。催产素受体(OXTR)允许身体对催产素做出反应，但其表达因人而异。这些受体受表观遗传控制，特别是通过DNA甲基化，这至少是这些个体差异的部分原因。在健康和紊乱人群中，OXTR甲基化与支持社会认知的大脑活动和不同的社会表型有关。将这种可靠的内源性表观遗传标记与功能磁成像和行为测试相结合，该方案检验了内源性催产素系统影响个人对社会信息敏感程度的假设。它的主要目的是(1)测试OXTR甲基化的变异性是否与社会信息处理过程中知觉和注意系统的不同参与有关；(2)评估OXTR甲基化水平低的个体是否依赖前额脑系统来抑制无关的社会信息；以及(3)评估OXTR甲基化与支持注意社会信息的神经系统之间的关系是否可以预测自我报告的社会性和独立评估的社会技能。

项目成果

Epigenetic modification of the oxytocin receptor gene is associated with emotion processing in the infant brain

• DOI: 10.1016/j.dcn.2019.100648
• 发表时间: 2019-06-01
• 期刊: DEVELOPMENTAL COGNITIVE NEUROSCIENCE
• 影响因子: 4.7
• 作者: Krol, Kathleen M.;Puglia, Meghan H.;Grossmann, Tobias
• 通讯作者: Grossmann, Tobias