Collaborative Research: Building a framework for the role of bacterial-derived chemical signals in mediating phytoplankton population dynamics

合作研究:建立细菌源化学信号在介导浮游植物种群动态中的作用框架

基本信息

  • 批准号:
    1657898
  • 负责人:
  • 金额:
    $ 25.33万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
    Standard Grant
  • 财政年份:
    2017
  • 资助国家:
    美国
  • 起止时间:
    2017-04-01 至 2021-03-31
  • 项目状态:
    已结题

项目摘要

Bacteria and phytoplankton play a central role in the modification and flow of materials and nutrients through the marine environment. While it has been established that interactions between these two domains are complex, the mechanisms that underpin these interactions remain largely unknown. There is increasing recognition, however, that dissolved chemical cues govern these microbial interactions. This project focuses on establishing a mechanistic framework for how bacterially derived signaling molecules influence interactions between phytoplankton and bacteria. The quorum-sensing (QS) molecule, 2-heptyl-4-quinolone (HHQ) will be used as a model compound for these investigations. Previously published work suggests that exposure to very low levels of HHQ results in phytoplankton mortality. Gaining a mechanistic understanding of these ecologically important interactions will help to inform mathematical models for the accurate prediction of the cycling of material through the marine microbial loop. This work initiates a new, hybrid workshop-internship undergraduate research program in chemical ecology, with a focus into bacteria-phytoplankton interactions. Undergraduate students participate in an intense summer learning experience where research and field-based exercises are supplemented with short-lecture based modules. Students return to their home institutions and work closely with the PIs to conduct interdisciplinary research relating to the aims and scope of the summer research. This research also provides training and career development to two graduate students and a postdoctoral scientist.Interactions between phytoplankton and bacteria play a central role in mediating biogeochemical cycling and microbial trophic structure in the ocean. The intricate relationships between these two domains of life are mediated via excreted molecules that facilitate communication and determine competitive outcomes. Despite their predicted importance, identifying these released compounds has remained a challenge. The PIs recently identified a bacterial QS molecule, HHQ, produced by globally distributed marine gamma-proteobacteria, which induces phytoplankton mortality. The PIs therefore hypothesize that bacteria QS signals are critical drivers of phytoplankton population dynamics and, ultimately, biogeochemical fluxes. This project investigates the timing and magnitude of HHQ production, and the physiological and transcriptomic responses of susceptible phytoplankton species to HHQ exposure, and quantifies the influence of HHQ on natural algal and bacterial assemblages. The work connects laboratory and field-based experiments to understand the governance of chemical signaling on marine microbial interactions, and has the potential to yield broadly applicable insights into how microbial interactions influence biogeochemical fluxes in the marine environment.
细菌和浮游植物在海洋环境中物质和营养物的改变和流动方面发挥着核心作用。虽然已经确定这两个域之间的相互作用是复杂的,但支持这些相互作用的机制在很大程度上仍然未知。然而,人们越来越认识到,溶解的化学信号控制着这些微生物的相互作用。该项目的重点是建立一个机制框架,细菌衍生的信号分子如何影响浮游植物和细菌之间的相互作用。群体感应(QS)分子,2-庚基-4-喹诺酮(HHQ)将被用作这些研究的模型化合物。先前发表的研究表明,接触极低水平的HHQ会导致浮游植物死亡。获得这些生态上重要的相互作用的机制的理解将有助于通知通过海洋微生物循环的材料的准确预测的数学模型。这项工作启动了一个新的,混合车间实习本科生化学生态学研究计划,重点是细菌浮游植物的相互作用。本科生参加一个激烈的夏季学习体验,其中研究和基于实地的练习补充了基于短期讲座的模块。学生回到自己的家乡机构,并与PI密切合作,进行与夏季研究的目标和范围有关的跨学科研究。这项研究还为两名研究生和一名博士后科学家提供了培训和职业发展。浮游植物和细菌之间的相互作用在介导海洋地球化学循环和微生物营养结构中起着核心作用。这两个生命领域之间的复杂关系是通过分泌的分子介导的,这些分子促进了交流并决定了竞争结果。尽管它们具有预测的重要性,但识别这些释放的化合物仍然是一个挑战。PI最近发现了一种细菌QS分子HHQ,由全球分布的海洋γ-变形菌产生,导致浮游植物死亡。因此,PI假设细菌QS信号是浮游植物种群动态的关键驱动因素,并最终导致地球化学通量。本项目调查了HHQ产生的时间和幅度,以及敏感浮游植物物种对HHQ暴露的生理和转录组学反应,并量化了HHQ对天然藻类和细菌组合的影响。这项工作将实验室和现场实验联系起来,以了解化学信号对海洋微生物相互作用的治理,并有可能对微生物相互作用如何影响海洋环境中的生物地球化学通量产生广泛适用的见解。

项目成果

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David Rowley其他文献

Targeting the tumor vasculature with TEM8-specific T cells
  • DOI:
    10.1186/2051-1426-2-s3-p42
  • 发表时间:
    2014-11-06
  • 期刊:
  • 影响因子:
    10.600
  • 作者:
    LaTerrica C Williams;Sunitha Kakarla;Simone Krebs;Thuy Phung;David Rowley;Stephen Gottschalk
  • 通讯作者:
    Stephen Gottschalk
316 SEMAPHORIN 4F AS A CRITICAL REGULATOR OF NEURO-EPITHELIAL INTERACTIONS AND A BIOMARKER OF AGGRESSIVE PROSTATE CANCER
  • DOI:
    10.1016/j.juro.2012.02.376
  • 发表时间:
    2012-04-01
  • 期刊:
  • 影响因子:
  • 作者:
    Gustavo Ayala;Yi Ding;Dandan He;Diego Florentin;Michael Ittmann;David Rowley
  • 通讯作者:
    David Rowley
Health benefits of joint replacement surgery for patients with osteoarthritis: prospective evaluation using independent assessments in Scotland.
关节置换手术对骨关节炎患者的健康益处:苏格兰使用独立评估进行的前瞻性评估。
Self-efficacy and goal importance in the prediction of physical disability in people following hospitalization: a prospective study.
自我效能和目标重要性在预测住院患者身体残疾方面的重要性:一项前瞻性研究。
  • DOI:
  • 发表时间:
    2001
  • 期刊:
  • 影响因子:
    7.9
  • 作者:
    S. Orbell;Marie Johnston;David Rowley;Peter Davey;Arthur Espley
  • 通讯作者:
    Arthur Espley
Development and validation of a musculoskeletal physical examination decision-making test for medical students.
医学生肌肉骨骼体检决策测试的开发和验证。
  • DOI:
  • 发表时间:
    2013
  • 期刊:
  • 影响因子:
    2.9
  • 作者:
    J. Bishop;Hisham M. Awan;David Rowley;R. Nagel
  • 通讯作者:
    R. Nagel

David Rowley的其他文献

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{{ truncateString('David Rowley', 18)}}的其他基金

Collaborative Research: Lhasa Block Top to Bottom-Lithospheric Evolution of Asia's Leading Edge
合作研究:拉萨地块自上而下——亚洲前沿的岩石圈演化
  • 批准号:
    1111274
  • 财政年份:
    2011
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Continuing Grant
Collaborative Research: Testing Models of Tibetan Plateau Uplift Using Stable Isotope-Based Paleoaltimetry
合作研究:使用基于稳定同位素的古温度测量法测试青藏高原隆起模型
  • 批准号:
    0609782
  • 财政年份:
    2006
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Continuing Grant
Collaborative Research: MIP: Bacterial Interactions and Processes that Regulate Biodiversity on Marine Organic Particles
合作研究:MIP:调节海洋有机颗粒生物多样性的细菌相互作用和过程
  • 批准号:
    0453843
  • 财政年份:
    2005
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Continuing Grant
Laboratory Studies of Polar Tropospheric Chemistry
极地对流层化学的实验室研究
  • 批准号:
    9906593
  • 财政年份:
    1999
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Standard Grant
Cenozoic Paleotopographic Evolution of the Tibetan Plateau
青藏高原新生代古地貌演化
  • 批准号:
    9973222
  • 财政年份:
    1999
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Standard Grant
Kinematics and Timing of Tectonic Exhumation along the Huwan and Taihu Detachments: Northern and Southern Boundaries of the Dabie/Tonghai Shan Ultra-High Pressure Terrain
沿湖湾支流和太湖支流的构造折返运动学和时限:大别山/通海山超高压地形的南北边界
  • 批准号:
    9805337
  • 财政年份:
    1998
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Continuing Grant
COLLABORATIVE RESEARCH: Time of Initiation of the India- Asia Collision East of Mount Everest
合作研究:珠穆朗玛峰以东印度-亚洲碰撞发生的时间
  • 批准号:
    9725817
  • 财政年份:
    1998
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Standard Grant
Mechanisms and Timing of the Exhumation of an Ultra-High Pressure Terrain, Dabie Shan, China
中国大别山超高压地形折返的机制和时间
  • 批准号:
    9305107
  • 财政年份:
    1993
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Continuing Grant
A Paleomagnetic Study of Middle Paleozoic to Lower Triassic Units in Guangxi, South China
广西中古生界至下三叠统地层的古地磁研究
  • 批准号:
    9206523
  • 财政年份:
    1992
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Standard Grant
Characterization of a Growth Inhibitory Activity from Urogenital Sinus
泌尿生殖窦生长抑制活性的表征
  • 批准号:
    9018138
  • 财政年份:
    1991
  • 资助金额:
    $ 25.33万
  • 项目类别:
    Standard Grant

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