REU Site: Control of Gene Expression for Biological Effect

REU 位点：控制基因表达以获得生物效应

• 批准号: 1659605
• 负责人: Thomas Gilmore
• 金额: $ 50.95万
• 依托单位: Trustees of Boston University
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1659605&HistoricalAwards=false
• 关键词: REU; Site; Control; Gene; Expression

This REU Site award to Boston University, located in Boston, MA, will support the training of 10 students for 10 weeks during each summer of 2017- 2020. Participants will conduct research experiments in the area of cell and molecular biology focusing on how changes in gene expression control biological processes, and they will be mentored in laboratories of faculty researchers in the Biology Department. Projects may involve investigating how transcription factors and gene expression changes play a role in development, differentiation, and the recognition of specific DNA sites. Students will receive training in conducting experiments, analyzing data, interpreting results, the oral presentation of scientific data, laboratory safety, and the ethical and responsible conduct of research, and will participate in a variety of educational, networking, and social activities with the larger Boston University summer research community. Participants will be selected by the Principal Investigator and potential faculty mentors after completion of an online application pool. Special emphasis will be placed on the recruitment of students from ethnic groups underrepresented in STEM research fields and from institutions (e.g., community colleges, non-PhD granting) without extensive access to research opportunities. It is anticipated that a total of 40 students, primarily from schools with limited research opportunities, will be trained in this program. Students will learn how research is conducted, and many will present the results of their work at scientific conferences.A common web-based assessment tool used by all REU Site programs funded by the Division of Biological Infrastructure will be used to determine the effectiveness of the training program. Students will be tracked after participation in the program in order to determine their career paths. There is special emphasis on the training of students who will choose research career paths in academia or industry, and it is anticipated that many students will pursue advanced degrees in the biological sciences. Students will be asked to respond to an automatic email sent via the NSF reporting system. More information about the program is available by visiting http://www.bu.edu/surf, or by contacting the PI (Dr. Thomas Gilmore at [e-mail]).

该REU网站奖授予位于马萨诸塞州波士顿的波士顿大学，将在2017- 2020年的每个夏天为10名学生提供为期10周的培训。参与者将在细胞和分子生物学领域进行研究实验，重点关注基因表达的变化如何控制生物过程，他们将在生物系教师研究人员的实验室接受指导。项目可能涉及研究转录因子和基因表达变化如何在发育、分化和特定DNA位点的识别中发挥作用。学生将接受有关进行实验、分析数据、解释结果、科学数据的口头陈述、实验室安全以及道德和负责任的研究行为的培训，并将与更大的波士顿大学暑期研究社区一起参加各种教育、网络和社会活动。参与者将在完成在线申请池后由首席研究员和潜在的教师导师选出。将特别强调招收在STEM研究领域中代表性不足的少数民族学生，以及那些无法获得广泛研究机会的机构（如社区学院、非博士学位授予机构）的学生。预计总共有40名学生，主要来自研究机会有限的学校，将在这个项目中接受培训。学生将学习如何进行研究，许多人将在科学会议上展示他们的工作成果。由生物基础设施部资助的所有REU站点计划使用的通用网络评估工具将用于确定培训计划的有效性。学生在参加项目后将被跟踪，以确定他们的职业道路。学校特别强调培养那些将在学术界或工业界选择研究职业道路的学生，预计许多学生将攻读生物科学的高级学位。学生将被要求回复通过NSF报告系统自动发送的电子邮件。有关该计划的更多信息，请访问http://www.bu.edu/surf，或与PI （Thomas Gilmore博士联系[e-mail]）联系。

项目成果

Discovering human transcription factor physical interactions with genetic variants, novel DNA motifs, and repetitive elements using enhanced yeast one-hybrid assays

• DOI: 10.1101/gr.248823.119
• 发表时间: 2019-09
• 期刊: Genome Research
• 影响因子: 7
• 作者: Shaleen Shrestha;J. Sewell;Clarissa S Santoso;Elena J. Forchielli;S. Carrasco Pro;Melissa Martinez;J. F. Fuxman Bass

Interspecific comparison of mushroom body synaptic complexes of dimorphic workers in the ant genus Pheidole

• DOI: 10.1016/j.neulet.2017.10.009
• 发表时间: 2018-01-01
• 期刊: NEUROSCIENCE LETTERS
• 影响因子: 2.5
• 作者: Gordon, Darcy G.;Zelaya, Alejandra;Traniello, James F. A.
• 通讯作者: Traniello, James F. A.

A conserved Toll-like receptor-to-NF-κB signaling pathway in the endangered coral Orbicella faveolata

• DOI: 10.1016/j.dci.2017.10.016
• 发表时间: 2018-02-01
• 期刊: DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
• 影响因子: 2.9
• 作者: Williams, Leah M.;Fuess, Lauren E.;Gilmore, Thomas D.
• 通讯作者: Gilmore, Thomas D.

Competitive growth in a social fish

• DOI: 10.1098/rsbl.2018.0737
• 发表时间: 2019-02-01
• 期刊: BIOLOGY LETTERS
• 影响因子: 3.3
• 作者: Reed, Cymone;Branconi, Rebecca;Buston, Peter
• 通讯作者: Buston, Peter

Voltage-gated sodium channel activity mediates sea urchin larval skeletal patterning through spatial regulation of Wnt5 expression

• DOI: 10.1242/dev.201460
• 发表时间: 2023-05-01
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Thomas，Christopher F.;Hawkins，Dakota Y.;Bradham，Cynthia A.
• 通讯作者: Bradham，Cynthia A.