SBIR Phase II: Fully Integrated Design and Automated Fabrication Services Software Platform for Engineering Living Systems

SBIR 第二阶段：工程生命系统的完全集成设计和自动化制造服务软件平台

• 批准号: 1660188
• 负责人: Kevin LeShane
• 金额: $ 75万
• 依托单位: Lattice Automation, Inc
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1660188&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Fully; Integrated

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project will be the development of a software platform for the engineering of living systems. Specifically, it will complete a software ecosystem that builds upon a core set of computational tools for the specification, design, build, test, analyze, and archive activities in synthetic biology and couple them with a rich set of interfaces to expert services (e.g., DNA synthesis, data analysis). The proposed work involves the completion of state-of-the-art design approaches and algorithms and couples it with the ability to create customized, modular workflows based on genetic circuit design, metabolic pathway modification, and genome engineering. The proposed work advances computational approaches in synthetic biology as well as innovating in the way that software services are monetized with biotechnology companies. The anticipated result of this work is a commercial software package and associated service agreements that can be deployed to both large and small biotechnology companies fundamentally changing the way that synthetic biology designs are conceived, designed, and physically created.This SBIR Phase II project will develop a software platform where the goal is to combine bio-design automation (BDA) software with explicitly integrated access to expert services in a workflow-driven software ecosystem. The creation of novel living systems using biotechnology to engineer new medicines, materials, and fuels is frequently an ad-hoc process involving long iteration cycles, wasted resources, and sub-optimal designs. The software will allow for the automated specification, design, fabrication, test, and archival of complete plans for the engineering of novel engineered biological systems. This software includes mechanisms for specifying biological "rules," DNA assembly strategies, and automated generation of robotic instructions. In particular, this effort will focus on the creation of genetic circuits, engineered metabolic pathways, and genome engineering. The approach provides tools representing state-of-the-art advances in BDA while introducing novel methods of interacting with a large, diverse set of expert service providers. Further, the approach will empower novice experimentalists while enabling expert computational engineers.

这个小企业创新研究（SBIR）第二阶段项目的更广泛的影响/商业潜力将是为生命系统工程开发软件平台。具体来说，它将完成一个软件生态系统，该生态系统建立在一组核心计算工具的基础上，用于合成生物学中的规范，设计，构建，测试，分析和存档活动，并将它们与一组丰富的专家服务接口（例如，DNA合成，数据分析）。拟议的工作涉及完成最先进的设计方法和算法，并将其与基于遗传电路设计，代谢途径修饰和基因组工程创建定制的模块化工作流程的能力相结合。拟议的工作推进了合成生物学的计算方法，并以生物技术公司将软件服务货币化的方式进行创新。这项工作的预期结果是一个商业软件包和相关的服务协议，可以部署到大型和小型生物技术公司，从根本上改变合成生物学设计的构思，设计，这个SBIR第二阶段项目将开发一个软件平台，其目标是将生物设计自动化（BDA）与联合收割机在工作流驱动的软件生态系统中，明确集成了对专家服务的访问。 利用生物技术来设计新的药物、材料和燃料，创造新的生命系统通常是一个特别的过程，涉及漫长的迭代周期、浪费资源和次优设计。该软件将允许自动化规格，设计，制造，测试和存档的完整计划，为工程的新的工程生物系统。该软件包括用于指定生物学“规则”、DNA组装策略和自动生成机器人指令的机制。 特别是，这项工作将集中在创建遗传电路，工程代谢途径和基因组工程。 该方法提供了代表BDA最新进展的工具，同时引入了与大量不同的专家服务提供商进行交互的新方法。此外，该方法将使新手实验者，同时使专家计算工程师。