SBIR Phase II: Anti-fouling surface modifications for purification membranes

SBIR第二阶段：净化膜的防污表面改性

• 批准号: 1660225
• 负责人: Adam Paxson
• 金额: $ 72.4万
• 依托单位: DropWise Technologies Corp.
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-04-01 至 2020-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1660225&HistoricalAwards=false
• 关键词: SBIR; Phase; II; Anti; fouling

This Small Business Innovation Research (SBIR) Phase II project will address the challenge of fouling on membranes used in biopharmaceutical processing. The successful application of this coating would enable increase in the membrane lifetime and product yield of various production streams as less of the valuable compounds remain trapped in the membrane. This can increase production capacity for life-saving medicines, reduce production costs and, in certain cases, enable continuous biopharmaceutical manufacturing. Furthermore, functionalization of membranes currently involve significant quantities of environmentally harmful solvents, which may be leachable during usage of the membrane. This issue is avoided in the current project by utilizing initiated chemical vapor deposition (iCVD) process which does not require any solvent. This coating technology can also be extended to other systems including wastewater purification, food & beverage production, industrial separations, and medical devices that rely on a similar functionalization.The objective of Phase II will be to demonstrate a commercially viable manufacturing process to produce surface modifications within porous membranes using the iCVD process. Previous work in this subject has focused on top-coats on the top surfaces of reverse osmosis membranes, but the chemistries utilized have never before been demonstrated within interior structures of the membrane filters. During the Phase II work, the performance of the coatings will be optimized by using existing deposition equipment to tune the coating chemistry and process conditions to maximize the flux and throughput by minimizing protein fouling. The other main technical goal of the work will be to translate the current batch process into a continuous roll-to-roll process that is amenable to large-scale manufacturing. The outcome of this study will be a proven coating chemistry that is effective and durable in the membrane application, and an optimized manufacturing process capable of being implemented within current standards of membrane manufacturing.

这个小型企业创新研究(SBIR)第二阶段项目将解决生物制药加工中使用的膜污染的挑战。这种涂层的成功应用将能够增加膜的寿命和各种生产流程的产品产量，因为膜中保留的有价值的化合物较少。这可以增加救命药物的生产能力，降低生产成本，并在某些情况下使生物制药能够持续生产。此外，目前膜的功能化涉及大量对环境有害的溶剂，这些溶剂在膜的使用过程中可能会被浸出。在目前的项目中，通过使用不需要任何溶剂的启动化学气相沉积(ICVD)工艺来避免这一问题。这种涂层技术还可以扩展到其他系统，包括废水净化、食品和饮料生产、工业分离和医疗设备，这些系统依赖于类似的功能化。第二阶段的目标是展示一种商业上可行的制造工艺，使用ICVD工艺在多孔膜内进行表面改性。本课题以前的工作主要集中在反渗透膜顶部表面的顶层，但所用的化学成分以前从未在膜过滤器的内部结构中得到证实。在第二阶段的工作中，将通过使用现有的沉积设备来调整涂层的化学和工艺条件，通过最大限度地减少蛋白质污染来最大限度地提高通量和生产能力，从而优化涂层的性能。这项工作的另一个主要技术目标将是将目前的批处理过程转化为适合大规模生产的连续卷对卷过程。这项研究的结果将是一种被证明在膜应用中有效和耐用的涂层化学，以及能够在当前膜制造标准内实施的优化制造工艺。