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SusChEM: Bimetallic Catalysis for C-C and C-X Bond Formation

SusChEM：用于 C-C 和 C-X 键形成的双金属催化

基本信息

批准号：
1664632
负责人：
Neal Mankad
金额：
$ 45万
依托单位：
University of Illinois at Chicago
依托单位国家：
美国
项目类别：
Continuing Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2021-04-30
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1664632&HistoricalAwards=false
关键词：
SusChEM Bimetallic Catalysis Bond Formation

项目摘要

Replacing precious metal catalysts with those using inexpensive and abundant metals is a major challenge faced by the chemistry community as precious metal resources dwindle and the focus on the environmental impact of chemical manufacturing increases. Successfully utilizing non-precious metal catalysts improves the sustainability, economics, and environmental impact of many technologies that are crucial to society. However, accomplishing this requires the development of new non-precious catalysts that function as well as, or better than, established precious metal catalysts. In this project, Dr. Mankad is developing a new strategy for catalyzing reactions of importance to the synthesis of fine chemicals and pharmaceuticals. The concept uses two non-precious metals to achieve chemical reactions typically conducted with a single precious metal. In addition to achieving the targeted chemical reactions, development of these innovative catalysts stands to impact many other areas of chemistry that rely on catalysis. Dr. Mankad is leading a diverse team of researchers and is promoting their engagement in outreach and leadership activities in their university and community. These activities, which include conducting chemistry demonstrations for urban middle school students in Chicago, promoting laboratory safety in research and teaching settings, and disseminating research results to a wide range of audiences, are promoting both interest in STEM disciplines and engagement in the issues of sustainability and environmental responsibility.With funding from the Chemical Catalysis Program of the Chemistry Division, Dr. Mankad of the University of Illinois at Chicago (UIC) is developing bimetallic strategies for C-C and C-X coupling reactions that utilize two base metals cooperatively to achieve transformations typically conducted using single-site noble metal catalysts. The targeted transformations include carbonylative C-C coupling reactions (typically catalyzed by Pd) that allow for the modular synthesis of ketone products from simple starting materials, dehydrogenative C-H borylation reactions (typically catalyzed by Ir) that allow for direct synthesis of arylboronic esters that are valuable synthetic building blocks, and alkyne semi-hydrogenation reactions (typically catalyzed by Pd, Ru, Rh, Ir) that exhibit unusual stereoselectivity dictated by the bimetallic reaction mechanism. The cooperation of two or more metals during catalysis is an under-developed design strategy, and so this project stands to have a broad impact on many other areas of chemistry that depend on catalysis. Dr. Mankad leads a diverse team of researchers and promotes their participation in outreach and leadership activities at UIC and in the surrounding Chicago community, including outreach to local middle school students, promotion of laboratory safety, and engagement in issues of sustainability and environmental responsibility, that further support the broader impacts of the project.

随着贵金属资源的减少和对化学制造对环境影响的关注增加，用廉价且丰富的金属取代贵金属催化剂是化学界面临的一个重大挑战。成功利用非贵金属催化剂可以改善许多对社会至关重要的技术的可持续性、经济性和环境影响。然而，实现这一点需要开发新的非贵金属催化剂，其功能与已建立的贵金属催化剂一样好或更好。在这个项目中，Mankad博士正在开发一种新的策略，用于催化精细化学品和药物合成的重要反应。该概念使用两种非贵金属来实现通常用单一贵金属进行的化学反应。除了实现目标化学反应外，这些创新催化剂的开发还将影响许多依赖催化的其他化学领域。Mankad博士领导着一个多元化的研究团队，正在促进他们在大学和社区中参与外联和领导活动。这些活动包括为芝加哥的城市中学生进行化学演示，促进研究和教学环境中的实验室安全，以及向广泛的受众传播研究成果，这些活动既促进了对STEM学科的兴趣，也促进了对可持续性和环境责任问题的参与。伊利诺伊大学芝加哥分校（UIC）的Mankad博士正在开发C-C和C-X偶联反应的催化剂策略，这些反应利用两种贱金属协同实现通常使用单位点贵金属催化剂进行的转化。目标转化包括羰基化C-C偶联反应（通常由Pd催化），其允许从简单的起始材料模块化合成酮产物，简化C-H硼基化反应（通常由Ir催化），其允许直接合成作为有价值的合成结构单元的芳基硼酸酯，以及炔半氢化反应（典型地由Pd、Ru、Rh、Ir催化），其表现出由催化剂反应机理决定的不寻常的立体选择性。两种或多种金属在催化过程中的合作是一种未开发的设计策略，因此该项目将对依赖催化的许多其他化学领域产生广泛的影响。Mankad博士领导着一支多元化的研究团队，并促进他们参与UIC和周围芝加哥社区的外联和领导活动，包括与当地中学生的外联，促进实验室安全，以及参与可持续发展和环境责任问题，进一步支持该项目的更广泛影响。