RUI: Synthesis of Highly Functionalized Heterocyclic Scaffolds

在这个由化学合成计划资助的RUI项目中，卡尔文学院化学和生物化学系的卡罗琳·安德森教授创造了合成复杂有机杂环的新方法。这些是环中含有氮的物质。新的合成路线主要基于金(III)催化的反应。具有挑战性的合成目标包括中氮杂环和异喹啉生物碱，这些杂环化合物具有潜在的药用价值。此外，该奖项还支持来自主要研究机构的高级研究生8-10周的暑期访问卡尔文学院。这些访问为未来作为PUI教员的职业生涯提供了培训。这项研究扩展了手性和非手性制备高度官能化的三取代吲哚氮和N-烷基2-吡啶酮结构的方法。这种新的化学使这些物种及其类似物可供更广泛的化学界使用。与机理和不对称金(III)催化有关的基础知识是本研究的重要成果。这些方法和目标的成功开发影响到合成社区以及那些参与有机材料、药物先导和不对称转化开发的社区。这项研究为本科生研究合作者和大学预科学生提供动手实验室培训，特别是那些来自历史上代表性不足的群体的学生。此外，这一奖项使打算主要在本科院校追求学术生涯的高级研究生能够在暑假期间作为PI实验室的成员度过一段时间。在这个角色中，来访的研究生获得了管理一个富有成效的本科生研究小组的基本经验，同时直接由PI指导。

In this RUI project funded by the Chemical Synthesis Program, Professor Carolyn Anderson of the Department of Chemistry and Biochemistry at Calvin College creates new methods for the synthesis of complex organic heterocycles. These are substances which contain nitrogen in a ring. New synthetic routes are primarily based on reactions catalyzed by gold (III). Challenging synthetic targets include indolizine and isoquinoline alkaloids, heterocyclic compounds which possess potential medicinal properties. In addition, this award supports 8-10 week summer visitations to Calvin College by senior graduate students from major research institutions. These visitations provide training for future careers as a PUI faculty member.This research expands the suite of chiral and achiral methods for preparing highly functionalized trisubstituted indolizine and N-alkyl 2-pyridone structures. This new chemistry makes these species, and their analogues, available to the broader chemical community. Basic knowledge related to mechanistic and asymmetric gold(III) catalysis is an important product of this research. Successful development of these methodologies and targets impacts the synthetic community as well as those involved in the development of organic materials, medicinal leads, and asymmetric transformations. This research provides hands-on laboratory training for undergraduate research collaborators and pre-college students, especially those from historically underrepresented groups. In addition, this award enables senior graduate students, who intend to pursue academic careers at primarily undergraduate institutions, to spend time during a summer as a member of the PI's laboratory. In this role, the visiting graduate students gain essential experience in running a productive undergraduate research group, while being mentored directly by the PI.