RUI: Synthesis of Highly Functionalized Heterocyclic Scaffolds

在这个由化学合成计划资助的RUI项目中，卡尔文学院化学与生物化学系的Carolyn Anderson教授创造了合成复杂有机杂环的新方法。这些物质在一个环中含有氮。新的合成路线主要是基于金（III）催化的反应。具有挑战性的合成目标包括吲哚嗪和异喹啉生物碱，具有潜在药用特性的杂环化合物。此外，该奖项支持来自主要研究机构的高级研究生到卡尔文学院进行为期8-10周的暑期访问。这些访问为PUI教师未来的职业生涯提供培训。本研究扩展了制备高功能化三取代吲哚嘧啶和n -烷基2-吡啶酮结构的手性和非手性方法。这种新的化学反应使这些物种和它们的类似物能够被更广泛的化学社区所利用。与机制和不对称金（III）催化有关的基础知识是本研究的重要成果。这些方法和目标的成功发展影响了合成界以及那些参与有机材料、药物先导和不对称转化开发的人。这项研究为本科生研究合作者和大学预科学生，特别是那些历史上代表性不足的群体提供了动手实验室培训。此外，该奖项还允许打算在主要本科院校追求学术生涯的高级研究生在夏季作为PI实验室的成员。在这个角色中，访问研究生获得了管理一个富有成效的本科生研究小组的基本经验，同时受到PI的直接指导。

In this RUI project funded by the Chemical Synthesis Program, Professor Carolyn Anderson of the Department of Chemistry and Biochemistry at Calvin College creates new methods for the synthesis of complex organic heterocycles. These are substances which contain nitrogen in a ring. New synthetic routes are primarily based on reactions catalyzed by gold (III). Challenging synthetic targets include indolizine and isoquinoline alkaloids, heterocyclic compounds which possess potential medicinal properties. In addition, this award supports 8-10 week summer visitations to Calvin College by senior graduate students from major research institutions. These visitations provide training for future careers as a PUI faculty member.This research expands the suite of chiral and achiral methods for preparing highly functionalized trisubstituted indolizine and N-alkyl 2-pyridone structures. This new chemistry makes these species, and their analogues, available to the broader chemical community. Basic knowledge related to mechanistic and asymmetric gold(III) catalysis is an important product of this research. Successful development of these methodologies and targets impacts the synthetic community as well as those involved in the development of organic materials, medicinal leads, and asymmetric transformations. This research provides hands-on laboratory training for undergraduate research collaborators and pre-college students, especially those from historically underrepresented groups. In addition, this award enables senior graduate students, who intend to pursue academic careers at primarily undergraduate institutions, to spend time during a summer as a member of the PI's laboratory. In this role, the visiting graduate students gain essential experience in running a productive undergraduate research group, while being mentored directly by the PI.