Magnetic Particle Imaging (MPI)-Gerät

磁性粒子成像（MPI）是一种新的成像技术，其可视化具有特定特性（高磁化率，非线性响应）的磁性氧化铁纳米颗粒（MNP）在三维中的分布-所谓的MPI示踪剂-具有高空间和时间分辨率并且没有干扰背景信号。MPI使用MNP作为血池标记物获得的初步结果表明，该方法具有很大的潜力，用于心血管成像和器官灌注的定量可视化以及分子成像和细胞跟踪的应用。另一方面，目前还没有临床批准的MPI示踪剂可用于开发MPI的这种潜力。此外，还没有完全理解MNP与生物基质的相互作用如何影响它们作为MPI示踪剂的性能。申请人及其来自德国联邦物理技术研究所的合作伙伴以及将参与自己项目的其他研究小组已经证明了他们在以下领域的专业知识：MNP在基础生物医学研究中的开发和应用，并转化为临床研究;表征MNP的测量技术;以及心血管医学、神经科学和流变学研究中的实验性体内成像。所申请的MPI扫描仪预期用于进行实验研究，涵盖以下方面：使用MPI进行定量成像;开发MPI-MNP作为研究试剂，但考虑到后期翻译;探索MPI在血管成像、心肌和其他器官定量灌注、前哨淋巴结成像、炎症成像中的潜在适应症，例如，动脉粥样硬化、心肌炎、关节炎和缺血性中风。

Magnetic Particle Imaging (MPI) is a new imaging technique that visualizes the distribution of magnetic iron oxide nanoparticles (MNPs) in three dimensions with specific properties (high susceptibility, nonlinear response) - so-called MPI tracers - with high spatial and temporal resolution and without interfering background signal. Initial results obtained with MPI using MNPs as blood pool markers suggest that the method has great potential for cardiovascular imaging and quantitative visualization of organ perfusion as well as for applications of molecular imaging and cell tracking. On the other hand, there exist at present no clinically approved MPI tracers that could be used to exploit this potential of MPI. Moreover, it is not yet fully understood how interactions of the MNPs with the biological matrix might affect their performance as MPI tracers. The applicant and his cooperation partner from the Physikalisch-Technische Bundesanstalt as well as additional study groups who will be involved with projects of their own have proven their expertise in the following areas: development and application of MNPs in basic biomedical research with translation to clinical research; measurement technology for characterizing MNPs; and experimental in vivo imaging in cardiovascular medicine, neurosciences, and rheumatological research. The MPI scanner applied for is intended for conducting experimental research covering the following aspects: quantitative imaging using MPI; Development of MPI-MNPs as research agents, but with a view to later translation; exploration of potential indications for MPI in vascular imaging, quantitative perfusion of myocardium and other organs, sentinel lymph node imaging, inflammatory imaging, e.g., atherosclerosis, myocarditis, arthritis, and ischemic stroke.