Transformative Iron Metal Nanoparticles with Controlled Oxidation for Magnetic Particle Imaging.

项目摘要 本研究致力于一种全新的铁的合成和表征。 在可控时间内转变为氧化铁纳米粒子的纳米粒子(在体内) 与提供生物兼容性和新颖的功能一致。 合成后，将对颗粒进行表征，以揭示其大小、结构、大小 分布和磁性。FeNPs的氧化程度将通过以下方式评估 穆斯堡尔光谱学。体外生物相容性将进行不同程度的测定。 氧化作用的结果。磁粉成像信号的大小和分辨率将是 被确定为FeNP氧化的函数。 本研究的具体目标包括：1)合成纳米铁颗粒 生物医学应用；2)物理表征和磁性测定 以及3)铁纳米粒子的定量表征、生物相容性 以及哺乳动物细胞的MP图像对比度。 我们将创造大小一致的铁纳米颗粒，涂层允许可控 氧化。然后，我们将演示这些材料的变革性能力 生产一种更灵敏的纳米颗粒，用于磁粒子成像。新的 纳米粒子的性能将与商业FeOxNP VivoTrax进行比较。 杰奎琳·约翰逊博士的研究小组在发展中进行了初步研究 这些纳米粒子和约翰逊博士是分析磁性物质的领先专家 材料的穆斯堡尔谱和许多初步表征 方法：研究方法。Giorgio博士的团队在适当的涂层方面拥有丰富的经验 纳米粒子和透射电子显微镜的研究。卢博士是一位专家 纳米粒子化学；卢博士和研究生研究助理阿莱娅·威廉姆斯一直 自2020年以来开发了FeNPs的合成方法。该项目将成为 Aleia和Vanderbilt GRA的博士工作，UTSI实习生的暑期研究和研究 范德比尔特大学常驻本科生的项目，在项目期间。总的来说， 这是针对不同级别的8-10名学生的培训。该小组将评估成像 由Magic Insight公司调查的业绩，他们正在制定 用于磁粒子成像的仪器。

Project Summary This study focusses on the synthesis and characterization of an entirely new class of iron nanoparticles that transition to iron oxide nanoparticles (in vivo) over a controllable period consistent with providing biocompatibility and novel function. After synthesis, the particles will be characterized to reveal their size, structure, size distribution and magnetic properties. The degree of oxidation of FeNPs will be assessed by Mössbauer spectroscopy. The in vitro biocompatibility will be determined at various extents of oxidation. The magnitude of magnetic particle imaging signal and resolution will be determined as a function of FeNP oxidation. The Specific Aims of our research include: 1) The synthesis of iron nanoparticles for biomedical applications; 2) physical characterization and magnetic property determination of the iron nanoparticles; and 3) quantitative characterization of FeNPs, biocompatibility and MP image contrast capability in mammalian cells. We will create iron nanoparticles of uniform size with coatings that allow controllable oxidation. We will then demonstrate the transformative capabilities of these materials in producing a more sensitive nanoparticle for magnetic particle imaging. The new nanoparticle performance will be compared with VivoTrax, a commercial FeOxNP. Dr. Jacqueline Johnson’s group has performed preliminary research in the development of these nanoparticles and Dr. Johnson is a leading expert on the analysis of magnetic materials using Mössbauer spectroscopy as well as many preliminary characterization methods. Dr. Giorgio’s group has extensive experience in appropriate coatings of nanoparticles and transmission electron microscopy studies. Dr. Lu is an expert in nanoparticle chemistry; Dr. Lu and graduate research assistant, Aleia Williams, have been developing synthesis methods of FeNPs since 2020. This project will form the basis of Aleia’s and Vanderbilt GRA’s PhD work, summer research for interns at UTSI and research projects for resident undergraduates at Vanderbilt, for the duration of the project. In total, this is training for 8-10 students at various levels. The group will assess imaging performance as investigated by the company Magnetic Insight, who are developing instrumentation for Magnetic Particle Imaging.