MOMENTUM+HYPER Magnetic Particle Imaging + Localised Hyperthermia Platform

MOMENTUM HYPER 磁粒子成像局部热疗平台

• 批准号: EP/W021579/1
• 负责人: Marco Giardiello
• 金额: $ 114.73万
• 依托单位: University of Liverpool
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2022
• 资助国家: 英国
• 起止时间: 2022 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=EP%2FW021579%2F1
• 关键词: MOMENTUM+HYPER; Magnetic; Particle; Imaging; Localised

The aim for this equipment is to install a Magnetic Particle Imaging (MPI) system with wide ranging capabilities spanning a broad range of multi-disciplinary research areas of significant national and global importance. The equipment provided by Magnetic Insight inc. is a ground-breaking research tool that integrates MPI with Magnetic Fluid Hyperthermia (MFH). MPI is an emerging imaging modality which uses magnetic fields gradients to detect low concentrations of magnetic nanoparticle tracers in vivo regardless of depth. The technology has many advantages over current, clinical imaging modalities such as MRI or CT. Unlike in other modalities, MPI tracers are imaged directly, which allows for highly sensitive, quantitative, and real-time detection with no background signal. Such sensitivity allows for high resolution, functional imaging, providing bright contrast and detection in areas where other imaging modalities fail; e.g. lungs, liver, gut, bone or tendon. MFH also uses magnetic field gradients, but at higher frequencies, to produce localised heating of magnetic nanoparticle, which can be used for various therapeutic applications, most notably ablation therapy for cancer where tumour tissues are destroyed through elevated local temperature increase. The unique system integrates both MPI and MFH for image guided ablation therapy study. Furthermore, the unique system comes equipped with software packages for both advanced magnetic material optimisation and advanced image reconstruction and signal enhancement studies. The unique mix of system capabilities will enable research spanning wide ranging interest:(1) Advanced Materials Discovery: inorganic and magnetic material synthesis of MPI tracers, MFH agents and composite image guided drug delivery agents for combined therapy and diagnostics, known as theranostics(2) Device Optimisation: computer science and mathematics in healthcare research into image reconstruction and multimodal imaging studies, as well as physics and engineering research towards the translation from preclinical to clinical devise development(3) Material Bio-Science Evaluation: bio-science research in material bio-safety and efficacy, drug safety science and the development of innovative technologies for regenerative medicineThe equipment would provide a novel facility within the UK research landscape, aligned strongly with the EPSRC Healthcare Technologies theme and the "Optimise Diagnosis and Treatment" and "Develop Future Therapeutic Technologies" themes of the EPSRC Healthy Nation Prosperity Outcome. The University of Liverpool is an ideal location for the equipment facility, with ongoing major investments across all the research themes the equipment encompasses.The equipment will be accessible to external academic and industry users, with researchers from UCL, Bristol, York, Cambridge, Keele and Warwick each expressing their planned equipment use. Furthermore, the equipment will enable collaborative research with industry, engaging with both UK based SMEs and global industry users. User engagement and user base expansion will benefit from planned Annual Researcher Meeting, focussed workshops and vendor-supported masterclasses, strengthening user skillsets and scientific knowledge and enhancing the overall user experience. Equipment strategic issues, such as priority of access and research impact generation, will be managed by an academic equipment steering committee, while the operational aspects of the equipment will be managed by technical committee who will oversee equipment smooth operations, system upkeep, and facilitating and training new users.

该设备的目的是安装具有广泛功能的磁性粒子成像（MPI）系统，涵盖了广泛的多学科研究领域，具有重要的国家和全球重要性。磁Insight Inc提供的设备。是一种开创性的研究工具，将MPI与磁性流体高温（MFH）集成在一起。 MPI是一种新兴的成像方式，它使用磁场梯度在体内检测低浓度的磁性纳米颗粒示踪剂，而不管深度如何。该技术比当前的临床成像方式（例如MRI或CT）具有许多优势。与其他方式不同，MPI示踪剂是直接成像的，这允许没有背景信号的高度敏感，定量和实时检测。这种敏感性允许高分辨率，功能成像，在其他成像方式失败的区域提供明亮的对比度和检测；例如肺，肝脏，肠道，骨头或肌腱。 MFH还使用磁场梯度，但在较高的频率下，可以生产磁性纳米颗粒的局部加热，可用于各种治疗应用，最值得注意的是癌症的消融疗法，在癌症中，肿瘤组织通过局部温度升高而破坏。独特的系统将MPI和MFH集成用于图像指导的消融治疗研究。此外，独特的系统配备了用于高级磁性材料优化和高级图像重建和信号增强研究的软件包。 The unique mix of system capabilities will enable research spanning wide ranging interest:(1) Advanced Materials Discovery: inorganic and magnetic material synthesis of MPI tracers, MFH agents and composite image guided drug delivery agents for combined therapy and diagnostics, known as theranostics(2) Device Optimisation: computer science and mathematics in healthcare research into image reconstruction and multimodal imaging studies, as well as physics and工程研究从临床前转移到临床设计开发（3）物质生物科学评估：物质生物安全和功效中的生物科学研究，药物安全科学以及用于再生医学设备的创新技术的开发将在英国的研究领域中提供优化的设施，并与Epsrc Nearlty and Intreal Care Inlore Crandies Intreal Crandies and Inutive Intreal Crandies and Inutive Intreal Careolcies Neverlecties Indory Indremies Indreolcies Indory''''治疗技术” EPSRC健康国家繁荣结果的主题。利物浦大学是设备设施的理想场所，所有研究主题均进行了持续的重大投资。设备包括外部学术和行业用户，来自UCL，Bristol，York，York，Cambridge，Keele，Keele，Keele和Warwick的研究人员都可以使用其计划的设备使用。此外，该设备将与行业进行合作研究，并与英国中小企业和全球行业用户互动。用户参与和用户群扩展将受益于计划的年度研究人员会议，重点的研讨会和供应商支持的大师班，增强用户技能和科学知识并增强整体用户体验。设备战略问题，例如优先获取和研究影响生成，将由学术设备指导委员会管理，而设备的运营方面将由技术委员会管理，这些委员会将监督设备平稳的操作，系统维护以及促进和培训新用户。