RI: Medium: Collaborative Research: Experimental and Robotics Investigations of Multi-Scale Spatial Memory Consolidation in Complex Environments

RI：媒介：协作研究：复杂环境中多尺度空间记忆整合的实验和机器人研究

• 批准号: 1703340
• 负责人: Jean-Marc Fellous
• 金额: $ 50.05万
• 依托单位: University of Arizona
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1703340&HistoricalAwards=false
• 关键词: RI; Medium; Collaborative; Research; Experimental

Navigation technologies are an increasingly important component of everyday life in an ever more dynamic and complex world. One limitation of these technologies is that they are optimized for a specific spatial scale. Another limitation is that they do not use the knowledge of previous navigation to compute new paths, essentially starting from scratch every time they are invoked. Recent evidence shows, however, that the mammalian brain has evolved to use multiple spatial navigation scales in parallel, and to use spatial memory to improve path planning. How these scales are used and what advantages such uses provide are still unknown. This project hypothesizes that multiscale spatial navigation is crucial in large and cluttered environments. Experiments recording from the neurons of the "brain GPS" system of the rodent (an excellent and efficient spatial navigator) seek to elucidate the basic principles of memory-based multiscale spatial navigation. These experiments will inform new algorithms that will be implemented on a computer to simulate complex multiscale spatial navigation, mimicking the neural computations of the brain. The simulations will then be tested and improved on actual autonomous mobile robots navigating in challenging complex environments.The project will use wireless high density neural recording technologies allowing for parallel recording of large populations of individual neurons. Optogenetic techniques will be used to manipulate the activity of these neurons and study their impact on the behavior and spatial memory of the animal. The multiscale pattern of neural activity will be used in the development of a mechanistic computational model, which will be tested in new and arbitrary simulated environments, and generate predictions as to how the neural system might succeed or fail. Finally, the simulations will be ported onto a mobile robot, where the algorithms can be tested and improved when the robot is faced with real sensor noise and unreliable world features.

在一个日益动态和复杂的世界中，导航技术是日常生活中日益重要的组成部分。这些技术的一个局限性是它们针对特定的空间尺度进行了优化。另一个限制是它们不使用以前导航的知识来计算新路径，每次调用它们时基本上都是从头开始。然而，最近的证据表明，哺乳动物的大脑已经进化到并行使用多个空间导航尺度，并使用空间记忆来改善路径规划。如何使用这些量表以及这些用途提供什么优势仍然未知。该项目假设多尺度空间导航在大而杂乱的环境中至关重要。实验记录的神经元的“大脑GPS”系统的啮齿动物（一个优秀的和有效的空间导航），试图阐明基于记忆的多尺度空间导航的基本原理。这些实验将提供新的算法，这些算法将在计算机上实现，以模拟复杂的多尺度空间导航，模仿大脑的神经计算。然后将在具有挑战性的复杂环境中导航的实际自主移动的机器人上对模拟进行测试和改进。该项目将使用无线高密度神经记录技术，允许并行记录大量单个神经元。光遗传学技术将用于操纵这些神经元的活动，并研究它们对动物行为和空间记忆的影响。神经活动的多尺度模式将用于开发一个机械计算模型，该模型将在新的和任意的模拟环境中进行测试，并生成关于神经系统如何成功或失败的预测。最后，模拟将被移植到一个移动的机器人，当机器人面临真实的传感器噪声和不可靠的世界功能时，可以测试和改进的算法。

项目成果

Complex spatial navigation in animals, computational models and neuro-inspired robots

动物、计算模型和神经机器人的复杂空间导航

• DOI: 10.1007/s00422-020-00832-y
• 发表时间: 2020
• 期刊: Biological Cybernetics
• 影响因子: 1.9
• 作者: Fellous, Jean-Marc;Dominey, Peter;Weitzenfeld, Alfredo
• 通讯作者: Weitzenfeld, Alfredo

Conjunctive reward–place coding properties of dorsal distal CA1 hippocampus cells

• DOI: 10.1007/s00422-020-00830-0
• 发表时间: 2020-04
• 期刊: Biological Cybernetics
• 影响因子: 1.9
• 作者: Zhuocheng Xiao;Kevin K. Lin;J. Fellous

A computational model for spatial cognition combining dorsal and ventral hippocampal place field maps: multiscale navigation

• DOI: 10.1007/s00422-019-00812-x
• 发表时间: 2020-01
• 期刊: Biological Cybernetics
• 影响因子: 1.9
• 作者: Pablo Scleidorovich;Martín Llofriu;J. Fellous;A. Weitzenfeld

The effects of time horizon and guided choices on explore–exploit decisions in rodents.

时间范围和引导选择对啮齿动物探索利用决策的影响。

• DOI: 10.1037/bne0000549
• 发表时间: 2023
• 期刊: Behavioral Neuroscience
• 影响因子: 1.9
• 作者: Wang, Siyu;Gerken, Blake;Wieland, Julia R.;Wilson, Robert C.;Fellous, Jean-Marc
• 通讯作者: Fellous, Jean-Marc

Dorsal CA1 hippocampal place cells form a multi-scale representation of megaspace

• DOI: 10.1016/j.cub.2021.03.003
• 发表时间: 2021-05-24
• 期刊: CURRENT BIOLOGY
• 影响因子: 9.2
• 作者: Harland, Bruce;Contreras, Marco;Fellous, Jean-Marc
• 通讯作者: Fellous, Jean-Marc