Next Generation Ca-P Cements for Treating Vertebral Body Fractures

该项目将开发和表征一种用于治疗椎体压缩性骨折的新型材料。脊柱的这种衰弱状态导致严重的疼痛，活动能力降低，并可能损害不同人群的器官功能。该团队将开发下一代磷酸钙骨水泥组合物，当注入骨折部位时，该组合物可以在短时间内自我固定并增强强度，而不会产生任何可能损害周围组织的热量。此外，这种新材料将被设计成具有在骨折部位诱导骨骼生长的能力，这将促进愈合。这个项目的创新之处在于材料的处理和成分的选择。生物材料开发的这两个方面共同努力，将创造出具有多种功能的新型组合物。这些新开发和优化的材料将在生物力学模型中进行测试，以模拟正常和骨质疏松的骨骼。由于原料是简单的化学物质，这种新材料预计将具有成本效益。这个项目将把各个层次的学生，从高中到研究生，整合到实验室。此外，将与托莱多市中心的高中建立一个指导计划，以激发学生对STEM领域的兴趣，特别是与生物工程和制造业相关的领域。最后，将与FDA一起为本科生开发一个合作项目，为学生提供医疗器械监管方面的经验。该项目的目标是设计，优化和充分表征-包括通过体外测试-磷酸钙基骨科水泥的新组合物。骨水泥主要是无水磷酸二钙（CaHPO4，也称为铁铁矿），它具有优化的吸收动力学，因此支持骨水泥在自然骨愈合过程中的生物降解。水泥中的颗粒将与纳米二氧化硅结合，以提供强度和骨导电性。额外的骨传导可以产生由于材料？将骨形态发生蛋白运送到受影响部位的能力。具体的科学目标将是：1)开发、检查和优化下一代磷酸钙基可注射骨科水泥的物理和机械特性；2)对脊柱模型（包括正常和骨质疏松）进行实验研究，以确定各种水泥组合物的体外性能；3)评估骨形成蛋白从水泥中释放的动力学及其对细胞附着和材料表面增殖的影响。

Award # 1706513PI: BhaduriThis project will develop and characterize a novel material for the treatment of vertebral body compression fractures. This debilitating condition of the spine causes severe pain, reduced mobility, and potentially compromised organ function in a diverse segment of the population. The team will develop a next-generation, calcium phosphate-based orthopedic cement composition that, when injected at the fracture site, self-sets and develops strength within a short time without any generation of heat that could damage the surrounding tissue. Furthermore, the new material will be designed such that it has the ability to induce bone growth at the site of the fracture, which will improve healing. The innovation in this project is related to both the processing of the material and the choice of compositions. Working together, these two aspects of biomaterials development will create novel compositions with a diverse range of capabilities. These newly developed and optimized materials will be tested in a biomechanical model to mimic both normal and osteoporotic bone. The new material is expected to be cost effective, as the starting materials are simple chemicals. This project will integrate students of all levels, from high school through graduate students, into the laboratory. In addition, a mentoring program will be established with inner-city Toledo high schools to excite students about STEM fields, particularly related to bioengineering and manufacturing. Finally, a co-op program for undergraduate students will be developed in conjunction with the FDA to provide students with experience in medical device regulation.The goal of this project is to design, optimize, and fully characterize - including through in vitro testing - novel compositions of a calcium phosphate-based orthopedic cement. The cement will be predominantly dicalcium phosphate anhydrous (CaHPO4, also known as monetite), which has optimized resorption kinetics and so supports biodegradation of the cement as the natural bone heals. The particles within the cement will be bonded with nano-silica to provide strength and osteoconductive properties. Additional osteoconduction can be generated due to the material?s ability to deliver bone morphogenic proteins to the affected site. The specific scientific objectives will be to: 1) develop, examine, and optimize the physical and mechanical characteristics of this next generation, calcium phosphate-based injectable orthopedic cement; 2) perform experimental studies on spinal models (both normal and osteoporotic) to determine the in vitro performance of the various cement compositions; and 3) evaluate the kinetics of bone morphogenic protein release from the cement as well as its impact on cell attachment and proliferation to the material surface.