Next Generation Ca-P Cements for Treating Vertebral Body Fractures

奖项#1706513 PI：Bhaduri该项目将开发和表征用于治疗椎体压缩性骨折的新型材料。 这种使人衰弱的脊柱状况在不同的人群中引起严重的疼痛、活动性降低和潜在的器官功能受损。 该团队将开发下一代基于磷酸钙的骨科骨水泥组合物，当注入骨折部位时，在短时间内自行固化并产生强度，而不会产生任何可能损害周围组织的热量。 此外，新材料的设计将使其能够在骨折部位诱导骨生长，这将改善愈合。 该项目的创新之处在于材料的加工和成分的选择。 生物材料开发的这两个方面共同努力，将创造出具有多种功能的新型组合物。 这些新开发和优化的材料将在生物力学模型中进行测试，以模拟正常骨和骨化骨。 新材料预计将具有成本效益，因为起始材料是简单的化学品。 这个项目将把从高中到研究生的所有层次的学生都纳入实验室。 此外，还将与托莱多市中心的高中建立一个辅导计划，以激发学生对STEM领域的兴趣，特别是与生物工程和制造业有关的领域。 最后，将与FDA合作开发一个针对本科生的合作项目，为学生提供医疗器械监管方面的经验。该项目的目标是设计、优化和充分表征-包括通过体外测试-磷酸钙基骨科骨水泥的新型成分。 骨水泥将主要是无水磷酸二钙（CaHPO 4，也称为三斜磷钙石），其具有优化的再吸收动力学，因此在天然骨愈合时支持骨水泥的生物降解。 骨水泥中的颗粒将与纳米二氧化硅结合，以提供强度和骨传导性能。 由于材料的原因，是否会产生额外的骨传导？的能力，提供骨形态发生蛋白的影响网站。 具体的科学目标将是：1）开发、检查和优化下一代磷酸钙基可注射骨科骨水泥的物理和机械特性; 2）在脊柱模型上进行实验研究（正常的和有害的）以确定各种骨水泥组合物的体外性能;和3）评价骨形态发生蛋白从骨水泥释放的动力学以及其对细胞附着和增殖到材料表面的影响。

Award # 1706513PI: BhaduriThis project will develop and characterize a novel material for the treatment of vertebral body compression fractures. This debilitating condition of the spine causes severe pain, reduced mobility, and potentially compromised organ function in a diverse segment of the population. The team will develop a next-generation, calcium phosphate-based orthopedic cement composition that, when injected at the fracture site, self-sets and develops strength within a short time without any generation of heat that could damage the surrounding tissue. Furthermore, the new material will be designed such that it has the ability to induce bone growth at the site of the fracture, which will improve healing. The innovation in this project is related to both the processing of the material and the choice of compositions. Working together, these two aspects of biomaterials development will create novel compositions with a diverse range of capabilities. These newly developed and optimized materials will be tested in a biomechanical model to mimic both normal and osteoporotic bone. The new material is expected to be cost effective, as the starting materials are simple chemicals. This project will integrate students of all levels, from high school through graduate students, into the laboratory. In addition, a mentoring program will be established with inner-city Toledo high schools to excite students about STEM fields, particularly related to bioengineering and manufacturing. Finally, a co-op program for undergraduate students will be developed in conjunction with the FDA to provide students with experience in medical device regulation.The goal of this project is to design, optimize, and fully characterize - including through in vitro testing - novel compositions of a calcium phosphate-based orthopedic cement. The cement will be predominantly dicalcium phosphate anhydrous (CaHPO4, also known as monetite), which has optimized resorption kinetics and so supports biodegradation of the cement as the natural bone heals. The particles within the cement will be bonded with nano-silica to provide strength and osteoconductive properties. Additional osteoconduction can be generated due to the material?s ability to deliver bone morphogenic proteins to the affected site. The specific scientific objectives will be to: 1) develop, examine, and optimize the physical and mechanical characteristics of this next generation, calcium phosphate-based injectable orthopedic cement; 2) perform experimental studies on spinal models (both normal and osteoporotic) to determine the in vitro performance of the various cement compositions; and 3) evaluate the kinetics of bone morphogenic protein release from the cement as well as its impact on cell attachment and proliferation to the material surface.