Pilot Study on early space closure to prevent gingival invaginations

早期间隙封闭预防牙龈套叠的初步研究

• 批准号: 228530729
• 负责人: Privatdozent Dr. Christoph Reichert
• 金额: --
• 依托单位: Institut für Klinische Chemie und Klinische Pharmakologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2014-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/228530729?language=en
• 关键词: Pilot; Study; early; space; closure

The factor time until initiation of orthodontic space closure after tooth extraction has been identified as a potential risk factor for the development of gingival invaginations in a retrospective study. The aim of this pilot study is to proof this hypothesis and to enable a caseload calculation for further clinical trials. The refering question is:Is it possible to reduce the number of developing gingival invaginations by initiation of orthodontic space closure after tooth extraction at an early point of time?In a randomised study the orthodontic space closure will be initiated at two different time intervals. A possible effect will be documented at the primary read out (moment of facilitated space closure) by documentation of the primary end point (reducted number of gingival invagination) and the secondary end point (reduction of the severity of gingival invaginations).

在一项回顾性研究中，拔牙后开始正畸间隙闭合的时间因素已被确定为牙龈内陷发生的潜在危险因素。这项试点研究的目的是证明这一假设，并为进一步的临床试验进行病例量计算。参考问题是：拔牙后尽早开始正畸间隙闭合是否可以减少牙龈内陷的数量？在一项随机研究中，正畸间隙闭合将在两个不同的时间间隔开始。通过记录主要终点（牙龈内陷数量减少）和次要终点（牙龈内陷严重程度减少），在主要读数（促进间隙闭合的时刻）记录可能的效果。