Development of unimolecular antibacterial nanomaterials

单分子抗菌纳米材料的研制

• 批准号: 1708500
• 负责人: Jianfeng Cai
• 金额: $ 39万
• 依托单位: University of South Florida
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-01 至 2021-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1708500&HistoricalAwards=false
• 关键词: Development; unimolecular; antibacterial; nanomaterials

Non-technical:This award by the Division of Materials Research to University of South Florida is to develop novel antibacterial nanomaterials. Due to the emerging resistance in the treatment of microbial diseases, development of new antimicrobial materials is of vital importance. Low-cost polymer-based materials are attractive. However, antimicrobial activity of currently available polymers is at best moderate. This project is to design a new class of unimolecular antibacterial nanomaterials with improved broad-spectrum activity. Through novel design, synthesis and mechanistic studies, more potent antimicrobial agents are expected with the proposed studies. These novel materials can be used for a variety of antimicrobial applications under different conditions. This project is highly interdisciplinary, and embraces cutting-edge chemistry, microbiology, and biomaterials. Both graduate and undergraduate students working in this research are expected to gain diverse expertise and experience. The successful outcome of this project is expected to advance the national interest because it will promote the scientific progress, advance the health and welfare of the U.S. citizens, and potentially improve the national biodefense.Technical:Due to the emerging antibiotic resistance among patients with different diseases, development of novel, potent and broad-spectrum, and low-cost antimicrobial biomaterials with less probability to develop drug-resistance is critical. To this end, this award will design dendrimer-based cationic nanomaterials with diverse functional groups, and controlled charge densities and distributions. The aims of this project are: 1) design and synthesis of nano-micelles with diverse functional groups, and controlled charge densities and distributions; 2) evaluation of the antibacterial activity and selectivity of the nanomaterials being developed against a panel of significant Gram-positive and Gram-negative bacteria; and 3) investigation of the mechanism for antimicrobial activity of these novel materials being developed with a focus on bacterial membrane disruption and bactericidal properties of the novel nano-micelles being studied. The project is highly interdisciplinary and embraces cutting-edge synthetic chemistry, microbiology, biomaterials, biophysics, and biochemistry. Both graduate and undergraduate students, with diverse scientific interests and backgrounds, will gain excellent learning experience with the studies carried out with this award.

非技术：南佛罗里达大学材料研究部颁发的这一奖项是为了开发新型抗菌纳米材料。由于在微生物疾病的治疗中出现耐药性，开发新的抗菌材料至关重要。低成本聚合物基材料很有吸引力。然而，目前可用的聚合物的抗菌活性充其量是中等的。本课题旨在设计一类新型的单分子抗菌纳米材料，提高其广谱活性。通过新的设计、合成和机理研究，有望开发出更有效的抗菌药物。这些新型材料可用于不同条件下的各种抗菌应用。这个项目是高度跨学科的，涵盖了前沿的化学、微生物学和生物材料。从事这项研究的研究生和本科生都有望获得不同的专业知识和经验。该项目的成功成果有望促进国家利益，因为它将促进科学进步，促进美国公民的健康和福利，并有可能改善国家生物防御。技术：由于不同疾病的患者出现抗生素耐药性，开发新型、强效、广谱、低成本、耐药可能性较小的抗菌生物材料至关重要。为此，该奖项将设计具有不同官能团的树突基阳离子纳米材料，并控制电荷密度和分布。本课题的目标是：1)设计和合成具有不同官能团的纳米胶束，并控制电荷密度和分布；2)评价正在开发的纳米材料对一组重要的革兰氏阳性和革兰氏阴性细菌的抗菌活性和选择性；3)研究这些新型材料的抗菌活性机制，重点研究了新型纳米胶束的细菌膜破坏和杀菌性能。该项目是高度跨学科的，包括前沿合成化学、微生物学、生物材料、生物物理学和生物化学。具有不同科学兴趣和背景的研究生和本科生都将通过该奖项进行的研究获得出色的学习经验。

项目成果

Antibacterial activity of lipo-α/sulfono-γ-AA hybrid peptides

脂-α/磺基-γ-AA 杂合肽的抗菌活性

• DOI: 10.1016/j.ejmech.2019.111901
• 发表时间: 2020
• 期刊: European Journal of Medicinal Chemistry
• 影响因子: 6.7
• 作者: Wei, Lulu;Wang, Minghui;Gao, Ruixuan;Fatirkhorani, Rojin;Cai, Jianfeng
• 通讯作者: Cai, Jianfeng

Polymyxin derivatives as broad-spectrum antibiotic agents

作为广谱抗生素的多粘菌素衍生物

• DOI: 10.1039/c9cc06908a
• 发表时间: 2019
• 期刊: Chemical Communications
• 影响因子: 4.9
• 作者: Su, Ma;Wang, Minghui;Hong, Yuzhu;Nimmagadda, Alekhya;Shen, Ning;Shi, Yan;Gao, Ruixuan;Zhang, En;Cao, Chuanhai;Cai, Jianfeng
• 通讯作者: Cai, Jianfeng

Nano-Sized Lipidated Dendrimers as Potent and Broad-Spectrum Antibacterial Agents

• DOI: 10.1002/marc.201800622
• 发表时间: 2018-12-01
• 期刊: MACROMOLECULAR RAPID COMMUNICATIONS
• 影响因子: 4.6
• 作者: Gide, Mussie;Nimmagadda, Alekhya;Cai, Jianfeng
• 通讯作者: Cai, Jianfeng