EAPSI: Rheology and Coalescence Behavior of Oil-Water Interfaces Stabilized by Soy Lecithin

EAPSI：大豆卵磷脂稳定的油水界面的流变学和聚结行为

• 批准号: 1713936
• 负责人: Jerome Nash
• 金额: $ 0.54万
• 依托单位: Nash Jerome J
• 依托单位国家: 美国
• 项目类别: Fellowship Award
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-06-01 至 2018-05-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1713936&HistoricalAwards=false
• 关键词: EAPSI; Rheology; Coalescence; Behavior; Oil

Emulsion-based delivery systems are widely applicable to a range of commercial applications (including pharmaceutical drug delivery, enhanced oil recovery, personal care products, and food processing) because these advanced material systems enable the delivery and controlled release of valuable active compounds. Coalescence (a destabilization process where two liquid droplets merge to form single, larger droplet) is an undesirable limiting factor for implementing these delivery systems within the foregoing commercial applications. Therefore, systematic investigations which improve current understanding of the dynamic processes that lead to droplet coalescence are crucially important. This project will be conducted in collaboration with Dr. Patrick Spicer, an Associate Professor at the University of New South Wales in Sydney, Australia and a noted expert on the production of shaped and targeted droplet delivery systems.The objective of this EAPSI project is to elucidate how nanoparticle-surfactant mixtures adsorbed to oil-water interfaces impact the interfacial rheology and observed coalescence behavior between neighboring oil-in-water droplets. It has been hypothesized that the presence of surfactants in Pickering (particle stabilized) emulsions can significantly modify particle interactions at the oil-water interface and thus improve an emulsion's resistance to coalescence dynamics. This theory will be explored for oil-in-water Pickering emulsions stabilized by silica nanoparticles (~500 nm dia.) and lecithin (one of the most widely used surfactants for the delivery of active compounds). Characterization of the co-adsorption and interfacial rheology of silica nanoparticles and lecithin molecules at the oil-water interface will be studied using pendant drop tensiometry procedures developed at Purdue University. Direct observation of dynamic coalescence processes between micrometer-scale oil droplets at relevant timescales (1 ms) will be conducted using custom micromanipulation equipment, optical microscopy, and high-speed imaging capabilities available through collaboration with Prof. Patrick Spicer at the University of New South Wales. The expected outcomes of this research will provide improved capacity for understanding and predicting the physical phenomena which govern the successful development of template emulsion-based delivery systems. This award, under the East Asia and Pacific Summer Institutes program, supports summer research by a U.S. graduate student and is jointly funded by NSF and the Australian Academy of Science.

基于乳剂的递送系统广泛应用于一系列商业应用(包括药物递送、提高石油采收率、个人护理产品和食品加工)，因为这些先进的材料系统能够递送和控制释放有价值的活性化合物。聚结(两个液滴合并形成更大的单个液滴的不稳定过程)是在上述商业应用中实施这些输送系统的一个不受欢迎的限制因素。因此，系统地研究提高目前对导致液滴合并的动态过程的理解是至关重要的。该项目将与澳大利亚悉尼新南威尔士大学副教授帕特里克·斯派塞博士合作进行，他是生产定形和靶向液滴输送系统的著名专家。该EAPSI项目的目标是阐明吸附到油水界面的纳米颗粒-表面活性剂混合物如何影响界面流变性和观察到相邻的水包油液滴之间的聚结行为。Pickering(颗粒稳定)乳状液中表面活性剂的存在可以显著改变油-水界面的颗粒相互作用，从而提高乳状液的抗聚并动力学性能。这一理论将被探索到由二氧化硅纳米颗粒(直径约500 nm)稳定的水包油Pickering乳剂中。和卵磷脂(用于输送活性化合物的最广泛使用的表面活性剂之一)。将使用普渡大学开发的悬滴张力计程序来研究二氧化硅纳米颗粒和卵磷脂分子在油-水界面上的共吸附和界面流变性的表征。将使用定制的微操作设备、光学显微镜和与新南威尔士大学Patrick Spicer教授合作提供的高速成像功能，在相关时间尺度(1 Ms)直接观察微米级油滴之间的动态聚结过程。这项研究的预期结果将提高理解和预测物理现象的能力，这些物理现象支配着模板乳剂递送系统的成功开发。该奖项根据东亚和太平洋夏季学院计划，支持一名美国研究生的暑期研究，由NSF和澳大利亚科学院联合资助。