EAGER: Turbulent Ventricular Cerebrospinal Fluid Flow Dynamics in Physiological and Pathological Conditions

计算模型正以越来越快的速度被应用于更好地理解和评估有害的人体生理影响。本项目是对脑脊液湍流的模拟研究。脑脊液被认为在中枢神经系统中循环，通过提供浮力来保护大脑免受创伤。脑脊液、脑脊液收容空间和脑脊液循环的异常与疾病有关。脑脊液流在脑室空间的湍流混合的生物力学是至关重要的。脑脊液生物湍流物理在改善大脑神经系统疾病的医学诊断和治疗方面具有潜在的变革性影响。该项目的目标包括全面了解湍流脑脊液流动动力学在中枢神经系统疾病病理中的作用。成功完成更广泛的目标产生了一个临床验证的湍流脑脊液计算框架。深入了解脑脊液流动的物理原理将提高脑脊液相关医学诊断和治疗的有效性，并改善个人在社会中的福祉。脑脊液在进入环绕大脑、脊髓和其他重要系统（如视神经系统）的蛛网膜下腔之前，经外侧脑室、第三脑室和第四脑室流动。在这个拟议的项目中，pi的重点是捕获和量化观察到的第三和第四脑室湍流脑脊液流动的动力学。脑脊液将被表示为不可压缩的牛顿流体，其密度和粘度与正常体温下的水相同。脑脊液流将用现代晶格玻尔兹曼方法求解。将浸入边界法应用于复杂脑脊液流道的非点阵一致性形状。建立颅内血管流动模型，研究颅内血管流动动力学。受试者特定模拟的结果将与基于磁共振成像数据的结果进行比较。计算模型在健康和患病情况下的具体应用将进行。

Computational models are being applied at increasing rate toward better understanding and assessment of deleterious human physiological effects. This project is a simulation study of the turbulent flow of cerebrospinal fluid. Cerebrospinal fluid is believed to circulate in the central nervous system, protecting the brain from trauma by providing buoyancy. Abnormalities in cerebrospinal fluid, its containment space, and its circulations have been related to diseases. The biomechanics of the turbulent mixing of the cerebrospinal fluid flow in the ventricular space is of paramount importance. The potential transformative impacts the cerebrospinal bio-turbulence physics has on improving the medical diagnosis and treatment of neurological disorders of the brain are significant. The objectives of this project include gaining a thorough understanding of the roles the physics of turbulent cerebrospinal fluid flow dynamics play in the pathologies of central nervous system disorders. A successful completion of the broader objectives produces a clinically validated computation framework for turbulent cerebrospinal fluid flow. An advanced understanding of the physics of the cerebrospinal fluid flow will improve the efficacy of cerebrospinal fluid-related medical diagnosis and treatments, and the well-being of individuals in society.Cerebrospinal fluid flow is believed to present throughout the lateral, the third and the fourth ventricles before entering the subarachnoid space, which surrounds the brain, the spinal cord, and other important systems, such as the optic nerve system. In this proposed project, the PIs focus on capturing and quantifying the dynamics of the observed turbulent cerebrospinal fluid flow in the third and the fourth ventricles. Cerebrospinal fluid will be represented by an incompressible Newtonian fluid with the same density and viscosity as those of water at the normal body core temperature. The cerebrospinal fluid flow will be resolved using a modern lattice Boltzmann method. An immersed boundary method will be applied to properly account for the non-lattice conforming shape of the complex cerebrospinal fluid flow passages. An intracranial vascular flow model will be developed for the cerebrovascular flow dynamics. The outcomes of the subject-specific simulations will be compared with those based on Magnetic Resonance Imaging data. Subject-specific applications of the computational model in a healthy and a diseased condition will be conducted.