EAGER: Turbulent Ventricular Cerebrospinal Fluid Flow Dynamics in Physiological and Pathological Conditions

EAGER：生理和病理条件下的湍流心室脑脊液流动动力学

• 批准号: 1723550
• 负责人: William Liou
• 金额: $ 20.38万
• 依托单位: Western Michigan University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-07-01 至 2021-06-30
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1723550&HistoricalAwards=false
• 关键词: EAGER; Turbulent; Ventricular; Cerebrospinal; Fluid

Computational models are being applied at increasing rate toward better understanding and assessment of deleterious human physiological effects. This project is a simulation study of the turbulent flow of cerebrospinal fluid. Cerebrospinal fluid is believed to circulate in the central nervous system, protecting the brain from trauma by providing buoyancy. Abnormalities in cerebrospinal fluid, its containment space, and its circulations have been related to diseases. The biomechanics of the turbulent mixing of the cerebrospinal fluid flow in the ventricular space is of paramount importance. The potential transformative impacts the cerebrospinal bio-turbulence physics has on improving the medical diagnosis and treatment of neurological disorders of the brain are significant. The objectives of this project include gaining a thorough understanding of the roles the physics of turbulent cerebrospinal fluid flow dynamics play in the pathologies of central nervous system disorders. A successful completion of the broader objectives produces a clinically validated computation framework for turbulent cerebrospinal fluid flow. An advanced understanding of the physics of the cerebrospinal fluid flow will improve the efficacy of cerebrospinal fluid-related medical diagnosis and treatments, and the well-being of individuals in society.Cerebrospinal fluid flow is believed to present throughout the lateral, the third and the fourth ventricles before entering the subarachnoid space, which surrounds the brain, the spinal cord, and other important systems, such as the optic nerve system. In this proposed project, the PIs focus on capturing and quantifying the dynamics of the observed turbulent cerebrospinal fluid flow in the third and the fourth ventricles. Cerebrospinal fluid will be represented by an incompressible Newtonian fluid with the same density and viscosity as those of water at the normal body core temperature. The cerebrospinal fluid flow will be resolved using a modern lattice Boltzmann method. An immersed boundary method will be applied to properly account for the non-lattice conforming shape of the complex cerebrospinal fluid flow passages. An intracranial vascular flow model will be developed for the cerebrovascular flow dynamics. The outcomes of the subject-specific simulations will be compared with those based on Magnetic Resonance Imaging data. Subject-specific applications of the computational model in a healthy and a diseased condition will be conducted.

计算模型正以越来越快的速度应用于更好地理解和评估有害的人体生理影响。本计画是一项脑脊髓液紊流的模拟研究。脑脊液被认为在中枢神经系统中循环，通过提供浮力来保护大脑免受创伤。脑脊髓液中的脑脊液、其容纳空间和其循环与疾病有关。脑室内脑脊液流动的湍流混合的生物力学是至关重要的。脑脊髓生物湍流物理学对改善脑神经系统疾病的医学诊断和治疗具有潜在的变革性影响。该项目的目标包括深入了解湍流脑脊液流动动力学在中枢神经系统疾病病理学中的作用。一个更广泛的目标的成功完成产生了一个临床验证的计算框架湍流脑脊液流动。对脑脊液流动物理学的深入了解将提高脑脊液相关医疗诊断和治疗的效率，以及社会中个人的福祉。脑脊液流动被认为在进入蛛网膜下腔之前存在于整个侧脑室，第三和第四脑室，蛛网膜下腔包围着大脑，脊髓和其他重要系统，例如视神经系统。在这个拟议的项目中，PI专注于捕获和量化在第三和第四脑室中观察到的湍流脑脊液流的动力学。脑脊液将由不可压缩的牛顿流体表示，其密度和粘度与正常体核温度下的水相同。将使用现代格子玻尔兹曼方法解决脑脊液流动。浸没边界法将被应用到适当的非晶格符合形状的复杂的脑脊液流动通道。建立了一个脑血管血流动力学模型。将受试者特定模拟的结果与基于磁共振成像数据的结果进行比较。将进行计算模型在健康和患病条件下的受试者特定应用。

项目成果

Cerebrospinal Fluid Flow Simulations during Head Nodding Motions

点头运动期间的脑脊液流动模拟

• 发表时间: 2021
• 期刊: AIP conference proceedings
• 作者: William W. Liou, Jin Xu

CEREBROSPINAL FLUID FLOW SIMULATIONS IN BRAIN VENTRICLES WITH ELASTIC WALL RESPONSES

具有弹性壁反应的脑室脑脊液流动模拟

• 发表时间: 2019
• 期刊: 6th International Conference on Computational and Mathematical Biomedical Engineering
• 作者: Liou, William W;Yang, Yang;Yamada, Shinya
• 通讯作者: Yamada, Shinya