Evaluation of a Left Ventricular Assist Device for Cardiopulmonary resuscitation during Cardiac Arrest

心脏骤停期间左心室辅助装置用于心肺复苏的评估

• 批准号: 230401553
• 负责人: Privatdozent Dr. Matthias Derwall
• 金额: --
• 依托单位: Institut für Neuropathologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2012
• 资助国家: 德国
• 起止时间: 2011-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/230401553?language=en
• 关键词: Evaluation; Left; Ventricular; Assist; Device

About one million people die from Sudden Cardiac Arrest in the western world anually. While more and more patients can be resuscitated on scene, many patients suffer from severe neurocognitive deficits due to the profound cerebral hypoxemia during cardiac arrest. Every other patient requires permanent medical care after hospital discharge. Therapeutic hypothermia (MTH) is the only clinically proven treatment to reduce neurologic sequelae in survivors of cardiac arrest. MTH intends to minimize the secondary reperfusion-inury, but does not target the primary cause of cerebral hypoperfusion - poor circulation during resuscitation efforts. Therefore we propose to evaluate the efficacy of a Left Ventricular Assist Device in a porcine model of cardiac arrest and Cardiopulmonary Resuscitation in in terms of the rate of return of spontaneous circulation, as well as clinical neurocognitive performance following CPR in comparison to conventional chest compressions.

在西方世界，每年约有100万人死于心脏骤停。虽然越来越多的患者可以现场复苏，但由于心脏骤停期间严重的脑低氧血症，许多患者患有严重的神经认知障碍。其他所有患者在出院后都需要永久医疗护理。治疗性低温(MTH)是唯一临床证明可以减少心脏骤停幸存者神经后遗症的治疗方法。MTH打算将二次再灌注率降至最低，但不针对脑低灌注的主要原因--复苏过程中的循环不良。因此，我们建议在心跳骤停和心肺复苏的猪模型中评价左心辅助装置的疗效，包括自主循环的返回率和CPR后的临床神经认知表现，并与传统的胸部按压相比较。