Evaluation of a Left Ventricular Assist Device for Cardiopulmonary resuscitation during Cardiac Arrest

在西方世界，每年约有100万人死于心脏骤停.虽然越来越多的患者可以在现场复苏，但许多患者由于心脏骤停期间严重的脑低氧血症而遭受严重的神经认知障碍。其他每一位病人在出院后都需要长期的医疗护理。治疗性低温（MTH）是唯一经临床证实的治疗，以减少心脏骤停幸存者的神经后遗症。MTH旨在最大限度地减少继发性再灌注损伤，但不针对脑灌注不足的主要原因-复苏过程中的循环不良。因此，我们建议评价左心室辅助装置在心脏骤停和心肺复苏猪模型中的有效性，即与传统胸外按压相比，心肺复苏后的自主循环恢复率以及临床神经认知表现。

About one million people die from Sudden Cardiac Arrest in the western world anually. While more and more patients can be resuscitated on scene, many patients suffer from severe neurocognitive deficits due to the profound cerebral hypoxemia during cardiac arrest. Every other patient requires permanent medical care after hospital discharge. Therapeutic hypothermia (MTH) is the only clinically proven treatment to reduce neurologic sequelae in survivors of cardiac arrest. MTH intends to minimize the secondary reperfusion-inury, but does not target the primary cause of cerebral hypoperfusion - poor circulation during resuscitation efforts. Therefore we propose to evaluate the efficacy of a Left Ventricular Assist Device in a porcine model of cardiac arrest and Cardiopulmonary Resuscitation in in terms of the rate of return of spontaneous circulation, as well as clinical neurocognitive performance following CPR in comparison to conventional chest compressions.