MRI: Acquisition of a 3D bioprinting system to generate composite biomaterials for regenerative medicine

MRI：收购 3D 生物打印系统以生成用于再生医学的复合生物材料

• 批准号: 1726634
• 负责人: Brendan Harley
• 金额: $ 25.35万
• 依托单位: University of Illinois at Urbana-Champaign
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-08-15 至 2019-07-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1726634&HistoricalAwards=false
• 关键词: MRI; Acquisition; 3D; bioprinting; system

This Major Research Instrumentation (MRI) grant awarded to the University of Illinois at Urbana-Champaign provides funding for the acquisition of a 3D-bioprinting instrument. Efforts at the University of Illinois are seeking to develop the next generation of tissue engineering solutions for critical healthcare needs such as musculoskeletal regeneration, models of cancer, cardiovascular repair, and controlling stem cell behavior. The EnvisionTEC 3D-Bioplotter will provide critical capabilities to fabricate large, geometrically complex, and cell-laden tissue biomaterials that mimic features of native tissues. This bioplotter will be operated as a shared-use bioprinting facility housed within the Carl R. Woese Institute for Genomic Biology (IGB) at the University of Illinois and will provide a critical resource to a broad user-base with diverse backgrounds to meet the needs of the tissue engineering community on our campus. The bioplotter will enhance the interdisciplinary training environment at the University of Illinois for trainees to gain the skills and confidence to address emergent challenges at the intersection of the biological, physical, and quantitative sciences. The bioplotter will also be integrated into innovative outreach and education programs at the IGB designed to expose students and the public to the transformative research programs within our institute. Advances in tissue engineering rely on successful integration of biomaterials, cells, and biologics such as growth factors and small molecules to address significant health care challenges. The EnvisionTEC 3D-Bioplotter acquired through this MRI program will be housed within the Carl R. Woese Institute for Genomic Biology (IGB) at the University of Illinois. This bioplotter system will enable transformative developing research efforts aimed at developing novel technologies and fundamental insight regarding biological phenomena required to promote the regeneration of human tissues and organs. The 3D-Bioplotter system will facilitate critical areas of biomaterial research across the University of Illinois community due to its capacity to generate large, geometrically complex, multiphase, and cell-laden tissue constructs. The bioplotter will be used to print diverse libraries of cell-infused hydrogel, ceramic, and polymeric bioinks, as well as composites thereof at the resolution required to mimic features of native tissue and organs in the body. This system provides critical operational capabilities for a biomaterials fabrication user-facility that serves the University of Illinois research community, specifically sterile operation, flexibility for bioink customization, the capacity for clinical-scale print volumes, and integrated feedback control essential for reproducibility. The bioplotter will be localized within the convergence-based research ecosystem at the IGB, which integrates disciplines of biology with technologies and approaches from engineering, computer science, physics, chemistry, mathematics, and the social sciences. The bioplotter will be managed as an open access facility to serve the needs of researchers from multiple departments and colleges across our campus, making it a central hub for tissue engineering efforts at the University of Illinois at Urbana-Champaign.

授予伊利诺伊大学厄巴纳-香槟分校的这项重大研究仪器（MRI）拨款为购买3D生物打印仪器提供资金。伊利诺伊大学正在努力开发下一代组织工程解决方案，以满足关键的医疗需求，如肌肉骨骼再生，癌症模型，心血管修复和控制干细胞行为。EnvisionTEC 3D-Biopsy将提供关键的能力，以制造大型，几何形状复杂的，充满细胞的组织生物材料，模仿天然组织的特征。这个生物打印机将作为一个共享使用的生物打印设施运行，位于卡尔R。Woese基因组生物学研究所（IGB）在伊利诺伊大学，并将提供一个重要的资源，以广泛的用户群具有不同的背景，以满足组织工程社区在我们的校园的需求。该bioprosts将加强在伊利诺伊大学的跨学科培训环境，为学员获得技能和信心，以解决在生物，物理和定量科学的交叉出现的挑战。生物技术还将被纳入IGB的创新推广和教育计划，旨在让学生和公众了解我们研究所内的变革性研究计划。 组织工程的进展依赖于生物材料、细胞和生物制剂（如生长因子和小分子）的成功整合，以应对重大的医疗保健挑战。通过该MRI程序获得的EnvisionTEC 3D-Biochemistry将置于Carl R.伊利诺伊大学Woese基因组生物学研究所（IGB）。这一生物再生系统将使变革性的发展研究工作能够进行，旨在开发新技术和关于促进人体组织和器官再生所需的生物现象的基本见解。该3D-Bioprostem系统将促进整个伊利诺伊大学社区的生物材料研究的关键领域，因为它能够生成大型，几何复杂，多相和细胞负载的组织结构。生物打印机将用于打印细胞注入的水凝胶、陶瓷和聚合物生物墨水的各种文库，以及以模拟体内天然组织和器官特征所需的分辨率打印其复合物。该系统为服务于伊利诺伊大学研究社区的生物材料制造用户设施提供了关键的操作能力，特别是无菌操作，生物墨水定制的灵活性，临床规模打印量的能力，以及对再现性至关重要的集成反馈控制。生物学将在IGB基于融合的研究生态系统中本地化，该生态系统将生物学学科与工程，计算机科学，物理，化学，数学和社会科学的技术和方法相结合。该生物工程将作为一个开放获取设施进行管理，以满足我们校园内多个部门和学院研究人员的需求，使其成为伊利诺伊大学厄巴纳-香槟分校组织工程工作的中心枢纽。