Epigenetic effects of early life on adult pathology

早期生命对成人病理学的表观遗传影响

• 批准号: 231416133
• 负责人: Professor Dr. Hartmut Schächinger
• 金额: --
• 依托单位: Fakultät für Sprachwissenschaften und Literatur, Geisteswissenschaften, Kunst und Erziehungswissenschaften
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/231416133?language=en
• 关键词: Epigenetic; effects; early; life; adult

Severe childhood adversity is thought to be one of the strongest risk factors for three major public health problems: cardiovascular disease, upper respiratory tract infections (URTI) and mental health problems. The three disease groups have all been linked to changes in how our body responds to stress. The main stress response system, the hypothalamus-pituitary-adrenal (HPA) axis, is conditioned by the environment, particularly during early life.The principal interface between the environment and the genome is epigenetic methylation of genomic DNA. There is a clear link between adverse early life experiences and disregulation of the HPA axis by epigenetic DNA methylation. The associated pathologies such as cardiovascular diseases and mental health problems have also been associated with epigenetic alterations. Our working hypothesis is that early life adversity induces high risk epigenetic modifications for the above disorders. We suggest that genome wide epigenetic modifications, implicated in all three of the above disease groups, have a common early life origin. This will be investigated in a cohort of young adults. It is also envisaged that the cohort will be maintained for follow-up studies of EpiPath and others. It can be anticipated that in future projects the prognostic and diagnostic value of the epigenetic marks identified in this project will be reexamined both as biomarkers of ELA and as risk factors for later-life pathologies.

严重的童年逆境被认为是心血管疾病、上呼吸道感染（URTI）和心理健康问题这三大公共卫生问题的最强风险因素之一。这三种疾病都与我们的身体对压力的反应方式的变化有关。主要的应激反应系统，下丘脑-垂体-肾上腺 (HPA) 轴，受到环境的调节，特别是在生命早期。环境和基因组之间的主要界面是基因组 DNA 的表观遗传甲基化。不良的早期生活经历与表观遗传 DNA 甲基化导致的 HPA 轴失调之间存在明显的联系。心血管疾病和心理健康问题等相关病理也与表观遗传改变有关。我们的工作假设是，早年的逆境会诱发上述疾病的高风险表观遗传修饰。我们认为，与上述所有三组疾病有关的全基因组表观遗传修饰具有共同的早期生命起源。这将在一组年轻人中进行调查。还预计该队列将被保留用于 EpiPath 和其他项目的后续研究。可以预见的是，在未来的项目中，该项目中确定的表观遗传标记的预后和诊断价值将作为 ELA 的生物标记和晚年病理的风险因素进行重新审查。

项目成果

Enhanced startle reflexivity during presentation of visual nurture cues in young adults who experienced parental divorce in early childhood.

在童年时期经历过父母离婚的年轻人在呈现视觉养育线索时惊吓反射性增强

• DOI: 10.1016/j.ijpsycho.2017.07.004
• 发表时间: 2017
• 期刊: International journal of psychophysiology : official journal of the International Organization of Psychophysiology
• 作者: Hengesch X;Larra MF;Finke JB;Blumenthal TD;Schächinger H
• 通讯作者: Schächinger H

Proinflammatory T Cell Status Associated with Early Life Adversity

• DOI: 10.4049/jimmunol.1701082
• 发表时间: 2017-12-15
• 期刊: JOURNAL OF IMMUNOLOGY
• 影响因子: 4.4
• 作者: Elwenspoek, Martha M. C.;Hengesch, Xenia;Muller, Claude P.
• 通讯作者: Muller, Claude P.

Glucocorticoid receptor signaling in leukocytes after early life adversity

• DOI: 10.1017/s0954579419001147
• 发表时间: 2020-08-01
• 期刊: DEVELOPMENT AND PSYCHOPATHOLOGY
• 影响因子: 3.3
• 作者: Elwenspoek, Martha M. C.;Hengesch, Xenia;Turner, Jonathan D.
• 通讯作者: Turner, Jonathan D.