EAGER: Developing Deformity-Specific Computational Models for Evaluating Novel Surgical Interventions for Treating Scoliosis in Pediatric Subjects

EAGER：开发特定于畸形的计算模型，用于评估治疗儿科受试者脊柱侧凸的新型手术干预措施

• 批准号: 1748167
• 负责人: Sriram Balasubramanian
• 金额: $ 20万
• 依托单位: Drexel University
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-01 至 2020-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1748167&HistoricalAwards=false
• 关键词: EAGER; Developing; Deformity; Specific; Computational

Spinal and rib cage deformities that result from scoliosis (curvature of the spine) in adolescents can have devastating consequences, including severe restrictions in mobility, pain, and problems with lung function. While spinal fusion surgery is the gold-standard for correcting scoliotic spine deformity, patient outcomes are generally poor as the fusion does not support the continued growth of the spine that is expected in this population. There is currently a lack of both adolescent cadaveric scoliotic spine specimens and computational models of the scoliotic spine, which severely limits the systematic engineering of improved surgical and device interventions for treating scoliosis. This project is developing and validating computer models of the adolescent, scoliotic spine and rib cage and then demonstrating the feasibility of such deformity-specific models in the medical device design process by optimizing novel spine deformity correction systems from Globus Medical, Inc. The scoliotic deformity-specific computer models will serve as predictive tools to reliably guide the design, placement, timing and method of surgical intervention. The modeling and simulation tools developed in this study will significantly reduce the time needed to design, test and implement investigational deformity correction devices, which will subsequently improve the quality of life for individuals with scoliosis. In addition to the research collaboration, this project is integrating undergraduate and graduate student training into the research project and providing them with opportunities for interaction and internships with a medical device company. This research project is pursuing three specific objectives to accomplish the overall goal of developing and validating a model of the adolescent, scoliotic spine. 1) This project is creating a finite element model template of the normal 10-year-old thoracolumbar spine (with pelvis) and rib cage and validating this model using in vitro kinematic data from biomechanical testing of adult cadaveric specimens. 2) The research team is developing a deformity-specific thoracolumbar spine (with pelvis) and rib cage finite element model for the Lenke 1AN curve type and validating this model using in vivo spine range of motion data previously collected from adolescents with scoliosis. 3) In collaboration with Globus Medical, Inc., the research team is conducting a feasibility study to apply the validated deformity-specific model for the design and placement optimizations of conventional scoliosis implants and a novel, growth-friendly spine deformity correction system. Upon completion of the proposed objectives, the foundation will be laid to effectively integrate medical image processing, computational modeling, and device design and testing for scoliosis treatment.

青少年脊柱侧凸（脊柱弯曲）导致的脊柱和胸廓畸形可能会产生毁灭性的后果，包括严重的活动受限、疼痛和肺功能问题。虽然脊柱融合手术是矫正脊柱侧凸畸形的金标准，但患者结局通常较差，因为融合不支持该人群预期的脊柱持续生长。目前缺乏青少年尸体脊柱侧凸脊柱标本和脊柱侧凸脊柱的计算模型，这严重限制了用于治疗脊柱侧凸的改进手术和器械干预的系统工程。该项目正在开发和验证青少年、脊柱侧凸脊柱和肋骨架的计算机模型，然后通过优化Globus Medical，Inc.的新型脊柱畸形矫正系统，证明此类畸形特定模型在医疗器械设计过程中的可行性。脊柱侧凸畸形特定的计算机模型将作为预测工具，以可靠地指导手术干预的设计、放置、时机和方法。本研究中开发的建模和模拟工具将显著缩短设计、测试和实施研究性畸形矫正器械所需的时间，从而改善脊柱侧凸患者的生活质量。除了研究合作之外，该项目还将本科生和研究生培训融入研究项目，并为他们提供与医疗器械公司互动和实习的机会。该研究项目追求三个具体目标，以实现开发和验证青少年脊柱侧凸脊柱模型的总体目标。1)该项目正在创建一个正常的10岁的胸腰椎脊柱（骨盆）和肋骨架的有限元模型模板，并使用来自成人尸体标本生物力学测试的体外运动学数据来验证该模型。2)该研究团队正在开发一种针对Lenke 1AN曲线类型的特定畸形的胸腰椎（带骨盆）和肋骨架有限元模型，并使用先前从青少年脊柱侧凸患者中收集的体内脊柱活动范围数据验证该模型。 3)与Globus Medical，Inc.合作，该研究小组正在进行一项可行性研究，以将经过验证的特定畸形模型应用于传统脊柱侧凸植入物和新型生长友好型脊柱畸形矫正系统的设计和放置优化。在完成所提出的目标后，将为有效整合脊柱侧凸治疗的医学图像处理、计算建模、器械设计和测试奠定基础。

项目成果

Morphing the feature-based multi-blocks of normative/healthy vertebral geometries to scoliosis vertebral geometries: development of personalized finite element models

• DOI: 10.1080/10255842.2018.1448391
• 发表时间: 2018-01-01
• 期刊: COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
• 影响因子: 1.6
• 作者: Hadagali, Prasannaah;Peters, James R.;Balasubramanian, Sriram
• 通讯作者: Balasubramanian, Sriram