CAREER: Wearable Joint Sounds Sensing for Children with Juvenile Idiopathic Arthritis

职业：为患有幼年特发性关节炎的儿童提供可穿戴式关节声音传感

• 批准号: 1749677
• 负责人: Omer Inan
• 金额: $ 50万
• 依托单位: Georgia Tech Research Corporation
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1749677&HistoricalAwards=false
• 关键词: CAREER; Wearable; Joint; Sounds; Sensing

Juvenile idiopathic arthritis (JIA) is the most common form of childhood arthritis and affects more than 50,000 children in the US. Symptoms and progression of JIA vary greatly between individuals, and there are many possible treatment options depending on the extent of disease. However, diagnosing JIA on a patient-by-patient basis is difficult because reliable tools for assessing the condition do not yet exist, and treatment is often a trial-and-error process. This project will focus on developing wearable joint health-sensing systems that continuously provide data on joint condition, inside and out of the clinic. The PI will focus on advancing the ability to measure and analyze sounds produced by joints during movement. The study will test the hypothesis that joint sounds decrease as joint health improves with therapy. Sounds collected with the wearable devices will be analyzed and compared with patients' joint health to understand possible relationships that can be used to improve diagnostic capabilities. Research and education are integrated through the incorporation of undergraduate research teams in the sensing brace design process and incorporating de-identified dataset analysis in courses at Georgia Institute of Technology. Additionally, the PI will host K-12 teachers in his lab to develop science and engineering modules to take back their classrooms.Dr. Inan's long-term career goal is to fundamentally advance knowledge in the field of wearable joint health sensing and, thereby, enable personalized therapies and devices for patients with joint disorders, such as arthritis. Toward this goal, Dr. Inan's research objectives are to: (1) design and implement a sensing brace capable of accurately measuring the sounds of the joints in the clinic and at home; (2) investigate algorithms for quantifying differences between the characteristics of joint sounds of patients with JIA and healthy controls; and (3) conduct a feasibility study in patients with JIA by sending the sensing brace home and evaluating the changes in joint sound characteristics measured throughout treatment. The PI's preliminary data suggests that joint sounds can potentially serve as a physiological biomarker for patients with arthritis. The project will first develop a wearable heterogenous sensor array for acoustical sensing with sufficient battery life. Experiments will collect joint sound data from JIA-affected and healthy patients. Graph mining algorithms will be applied to analyze the high-dimensional joint acoustical emissions data and correlate the data with joint health. At project completion, Dr. Inan will have developed a new physiological measurement tool for diagnosing and treating JIA patients based on their specific symptoms and responses to treatment, ultimately improving their quality of life and minimizing permanent joint damage.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

青少年特发性关节炎（JIA）是儿童关节炎最常见的形式，在美国影响超过50,000名儿童。JIA的症状和进展在个体之间差异很大，根据疾病的程度有许多可能的治疗选择。然而，在逐个患者的基础上诊断JIA是困难的，因为尚不存在评估病情的可靠工具，而且治疗往往是一个反复试验的过程。该项目将专注于开发可穿戴式关节健康传感系统，该系统可以在诊所内外持续提供关节状况数据。PI将专注于提高测量和分析关节在运动过程中产生的声音的能力。该研究将验证关节声音会随着治疗改善而减少的假设。可穿戴设备收集的声音将被分析，并与患者的关节健康状况进行比较，以了解可能的关系，可用于提高诊断能力。通过将本科生研究团队纳入传感支架设计过程，并将去识别数据集分析纳入佐治亚理工学院的课程，将研究和教育结合起来。此外，PI还将邀请K-12教师到他的实验室开发科学和工程模块，以收回他们的课堂。伊南的长期职业目标是从根本上推进可穿戴关节健康传感领域的知识，从而为关节炎等关节疾病患者提供个性化的治疗和设备。为了实现这一目标，Inan博士的研究目标是：(1)设计并实现一种能够在诊所和家中准确测量关节声音的传感支架；(2)研究JIA患者与健康对照者关节音特征差异的量化算法；(3)在JIA患者中进行可行性研究，将传感支架送回家，评估整个治疗过程中测量到的关节声音特性的变化。PI的初步数据表明，关节的声音有可能作为关节炎患者的生理生物标志物。该项目将首先开发一种可穿戴的异质传感器阵列，用于具有足够电池寿命的声学传感。实验将收集jia患者和健康患者的关节声音数据。图挖掘算法将用于分析高维关节声发射数据，并将数据与关节健康相关联。项目完成后，Inan博士将开发出一种新的生理测量工具，根据JIA患者的特定症状和治疗反应来诊断和治疗JIA患者，最终提高他们的生活质量，最大限度地减少永久性关节损伤。该奖项反映了美国国家科学基金会的法定使命，并通过使用基金会的知识价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

A Pilot Study to Assess the Reliability of Sensing Joint Acoustic Emissions of the Wrist

• DOI: 10.3390/s20154240
• 发表时间: 2020-08-01
• 期刊: SENSORS
• 影响因子: 3.9
• 作者: Hochman, Daniel M.;Gharehbaghi, Sevda;Inan, Omer T.
• 通讯作者: Inan, Omer T.

Acoustic emissions of the temporomandibular joint in children: proof of concept

儿童颞下颌关节的声发射：概念证明

• DOI: 10.21037/fomm-20-10
• 发表时间: 2020
• 期刊: Frontiers of Oral and Maxillofacial Medicine
• 作者: Whittingslow, Daniel C.;Orlandic, Lara;Gergely, Talia;Prahalad, Sampath;Inan, Omer T.;Abramowicz, Shelly
• 通讯作者: Abramowicz, Shelly

Acoustic Emissions Generated By the Temporomandibular Joint of Patients with Juvenile Idiopathic Arthritis and Their Implication on Patient Assessment and Screening: A Pilot Study

幼年特发性关节炎患者颞下颌关节产生的声发射及其对患者评估和筛查的影响：一项初步研究

• 发表时间: 2018
• 期刊: American College of Rheumatology ACR/ARHP Annual Meeting
• 作者: D. Whittingslow, H.-K. Jeong

A Glove-Based Form Factor for Collecting Joint Acoustic Emissions: Design and Validation

• DOI: 10.3390/s19122683
• 发表时间: 2019-06-02
• 期刊: SENSORS
• 影响因子: 3.9
• 作者: Bolus, Nicholas B.;Jeong, Hyeon Ki;Inan, Omer T.
• 通讯作者: Inan, Omer T.

Acoustic Emissions From Loaded and Unloaded Knees to Assess Joint Health in Patients With Juvenile Idiopathic Arthritis

通过加载和卸载膝盖的声发射来评估幼年特发性关节炎患者的关节健康状况

• DOI: 10.1109/jbhi.2021.3081429
• 发表时间: 2021
• 期刊: IEEE Journal of Biomedical and Health Informatics
• 影响因子: 7.7
• 作者: Gharehbaghi, Sevda;Whittingslow, Daniel C.;Ponder, Lori A.;Prahalad, Sampath;Inan, Omer T.
• 通讯作者: Inan, Omer T.