CAREER: Determining the Dynamic Role of Elastic Fibers in Cervovaginal Adaptations
职业:确定弹性纤维在宫颈阴道适应中的动态作用
基本信息
- 批准号:1751050
- 负责人:
- 金额:$ 50万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-07-01 至 2024-06-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This Faculty Early Career Development Program (CAREER) project will support an integrated research and education program to determine the role of elastic fibers in the soft tissues of the female reproductive system. Elastic fibers are present in most soft biological tissues and are critical to tissue function. Loss of elastic fibers may contribute to significant health problems of the female pelvic floor and lead to preterm birth and pelvic organ prolapse. This project will develop a computer model that can predict how elastic fibers in the soft tissues of the female reproductive system change in response to mechanical pressure. This will help to advance health by determining causes for changes in the tissue properties during pregnancy and during other normal events that change tissue mechanical pressure. The knowledge and new computer modeling tools could also be used to understand how other soft tissues containing elastic fibers such as the lungs, blood vessels, skin, and the digestive system change as the result of applied mechanical pressure. Research findings from this project will be incorporated into a mobile telephone game, teaching modules for K-12 education and into undergraduate and graduate biomedical engineering courses.An experimentally-validated computational model will be used to determine why and how elastic fibers influence mechanobiological adaptations in biological tissues. This will be accomplished by: 1) Determining the role of elastic fibers in evolving biaxial mechanical properties and contractility in cervovaginal tissue in response to altered loads in situ using a mechanical loading tissue culture system; 2) Formulating a biomechanical growth and remodeling model that describes cervovaginal mechanical properties, contractility, and extracellular matrix composition with and without compromised elastic fibers; and 3) Validating the model by predicting the key features of cervovaginal adaptations in response to altered mechanical loading.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
该学院早期职业发展计划(CAREER)项目将支持综合研究和教育计划,以确定弹性纤维在女性生殖系统软组织中的作用。弹性纤维存在于大多数软生物组织中,并且对组织功能至关重要。弹性纤维的损失可能会导致女性骨盆底的严重健康问题,并导致早产和盆腔器官脱垂。该项目将开发一个计算机模型,可以预测女性生殖系统软组织中的弹性纤维如何响应机械压力而变化。这将有助于通过确定在怀孕期间和在改变组织机械压力的其他正常事件期间组织特性变化的原因来促进健康。 这些知识和新的计算机建模工具也可以用来了解其他含有弹性纤维的软组织,如肺,血管,皮肤和消化系统如何因施加机械压力而发生变化。该项目的研究成果将被纳入移动的电话游戏、K-12教育的教学模块以及本科生和研究生生物医学工程课程。实验验证的计算模型将用于确定弹性纤维为什么以及如何影响生物组织中的机械生物学适应。这将通过以下方式实现:1)使用机械负荷组织培养系统,确定弹性纤维在宫颈阴道组织中响应于原位改变的负荷而演变双轴机械性质和收缩性中的作用; 2)制定生物力学生长和重塑模型,其描述了具有和不具有受损弹性纤维的宫颈阴道机械性质、收缩性和细胞外基质组成; 3)通过预测宫颈阴道适应改变的机械负荷的关键特征来验证模型。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查标准进行评估而被认为值得支持。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Kristin Miller其他文献
FEASIBILITY OF “FUNCTIONAL CORONARY INTERVENTION”
- DOI:
10.1016/s0735-1097(20)32079-9 - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Barry F. Uretsky;Shiv Kumar Agarwal;Rimsha Hasan;Srikanth Vallurupalli;Kristin Miller;Malek Al-Hawwas;Abdul Hakeem - 通讯作者:
Abdul Hakeem
Results from a type two hybrid‐effectiveness study to implement a preoperative anemia and iron deficiency screening, evaluation, and management pathway
实施术前贫血和缺铁筛查、评估和管理途径的二类混合有效性研究的结果
- DOI:
10.1111/trf.17287 - 发表时间:
2023 - 期刊:
- 影响因子:2.9
- 作者:
Alana Delaforce;S. Farmer;J. Duff;J. Munday;Kristin Miller;L. Glover;Chris Corney;Gareth Ansell;Naadir Gutta;H. Tuffaha;J. Hardy;C. Hurst - 通讯作者:
C. Hurst
Case Report: 52 Year-Old Male 11 Months after MUD for Angionimmunoblastic T Cell Lymphoma Developed Acute Fibrinous Organizing Pneumonitis Successfully Treated with Etanercept Suggesting TNF Alpha in the Pathogenesis in This Sub-Type of Pulmonary GVHD
- DOI:
10.1016/j.bbmt.2014.11.555 - 发表时间:
2015-02-01 - 期刊:
- 影响因子:
- 作者:
Gary Lee Simmons;William Clark;Harold Chung;Kristin Miller - 通讯作者:
Kristin Miller
Smartphone-Guided Self-prone Positioning vs Usual Care in Nonintubated Hospital Ward Patients With COVID-19
智能手机引导的自我俯卧位与非插管医院病房 COVID-19 患者的常规护理
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:9.6
- 作者:
G. Rampon;Shijing Jia;R. Agrawal;Nicholas R Arnold;Alejandro Martín;Ernest A Fischer;J. Malatack;N. Jagan;Amen Sergew;A. Case;Kristin Miller;M. Tanios;G. Doros;C. Ross;Michael A. Garcia;Kari R. Gillmeyer;Nicholas G. Griffiths;B. Jandali;Katherine L. Modzelewski;J. Rucci;S. Simpson;A. Walkey;N. Bosch - 通讯作者:
N. Bosch
Pleuroparenchymal Fibroelastosis Associated With Autologous Stem Cell Transplant
- DOI:
10.1378/chest.1987087 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:
- 作者:
Kristyn Sayball;Kristin Miller;Margaret Grimes;Harold Chung - 通讯作者:
Harold Chung
Kristin Miller的其他文献
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{{ truncateString('Kristin Miller', 18)}}的其他基金
Elastic Fiber Regeneration Potential During Postpartum Healing
产后愈合期间的弹性纤维再生潜力
- 批准号:
2326797 - 财政年份:2022
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
Elastic Fiber Regeneration Potential During Postpartum Healing
产后愈合期间的弹性纤维再生潜力
- 批准号:
1947770 - 财政年份:2020
- 资助金额:
$ 50万 - 项目类别:
Standard Grant
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