Elastic Fiber Regeneration Potential During Postpartum Healing
产后愈合期间的弹性纤维再生潜力
基本信息
- 批准号:1947770
- 负责人:
- 金额:$ 49.17万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Standard Grant
- 财政年份:2020
- 资助国家:美国
- 起止时间:2020-07-01 至 2023-05-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This work will promote the progress of science by measuring the potential of elastic fibers to regenerate during postpartum healing and how this potential varies with the age of the mother. Elastic fibers may regenerate during pregnancy to accommodate the growing fetus. This also benefits the mother during postpartum healing. However, the ability of these elastic fibers to regenerate may decrease as the mother ages. This may cause complications such as pelvic floor disorders. This award will support fundamental research to better understand how elastic fiber regeneration in the female reproductive system changes during postpartum healing and with aging. This award will also develop a new mathematical model to describe how elastic fiber regeneration controls tissue function. These elastic fibers are critical to the function of most soft biological tissues. Therefore, this model may also be used to better understand the mechanical behavior of other soft tissues that elastic fibers, such as the lungs, blood vessels, or skin. Further, the mathematical model will tell us if the results we learn by studying postpartum healing can be used to identify therapies that aim to treat, and ultimately prevent, medical problems that arise due to disrupted elastic fibers in other tissues. Research findings from this project will be incorporated into a tabletop board game, teaching modules for K-12 education, and into undergraduate and graduate biomedical engineering courses.Elastic fibers are critical for biological tissue homeostasis as they not only provide resilience and recoil but may also physically tether cells and other proteins within biological tissues that dictate function. Prior work suggests that regeneration and remodeling of elastic fibers during postpartum healing is critical to maintaining reproductive tissue health. Elastic fiber composition and relative arrangement to other cells and proteins during postpartum healing and aging is unknown. Therefore, this award will determine how elastic fibers dictate the evolving biological tissue microstructure and mechanical function during aging and postpartum healing. In particular, the evolving orientation and relative arrangement of elastic fibers with respect to cells and other biological proteins will be quantified and directly incorporated into a new mathematical model to better understand how elastic fiber regeneration dictates tissue contractility and function. This will be accomplished by: 1) Formulating and validating a biomechanical model that describes the vaginal extracellular matrix, mechanics, and contractility with increasing maternal age; and 2) Determining the effect of maternal age on elastic fiber regeneration and evolving mechanical properties during postpartum healing.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项工作将通过测量弹性纤维在产后愈合过程中再生的潜力以及这种潜力如何随着母亲的年龄而变化来促进科学的进步。 弹性纤维可以在怀孕期间再生,以适应不断生长的胎儿。 这也有利于母亲在产后愈合。然而,随着母亲年龄的增长,这些弹性纤维的再生能力可能会下降。 这可能会导致并发症,如骨盆底疾病。该奖项将支持基础研究,以更好地了解女性生殖系统中弹性纤维再生在产后愈合和衰老过程中的变化。该奖项还将开发一种新的数学模型来描述弹性纤维再生如何控制组织功能。这些弹性纤维对大多数软生物组织的功能至关重要。因此,该模型也可用于更好地理解弹性纤维的其他软组织的机械行为,例如肺、血管或皮肤。此外,数学模型将告诉我们,我们通过研究产后愈合所获得的结果是否可以用于确定旨在治疗并最终预防由于其他组织中的弹性纤维断裂而引起的医疗问题的疗法。该项目的研究成果将被纳入桌面棋盘游戏,K-12教育的教学模块,以及本科和研究生生物医学工程课程。弹性纤维对生物组织的稳态至关重要,因为它们不仅提供弹性和反冲力,而且还可以物理地束缚生物组织内决定功能的细胞和其他蛋白质。先前的工作表明,产后愈合期间弹性纤维的再生和重塑对维持生殖组织健康至关重要。在产后愈合和衰老过程中,弹性纤维的组成和与其他细胞和蛋白质的相对排列是未知的。因此,该奖项将确定弹性纤维如何决定衰老和产后愈合过程中不断变化的生物组织微观结构和机械功能。特别是,弹性纤维相对于细胞和其他生物蛋白质的演变方向和相对排列将被量化并直接纳入新的数学模型中,以更好地理解弹性纤维再生如何决定组织收缩性和功能。这将通过以下方式实现:1)制定和验证描述阴道细胞外基质、力学和收缩性随母亲年龄增加的生物力学模型;和2)确定产妇年龄对弹性纤维再生的影响,以及产后愈合过程中不断变化的机械性能。该奖项反映了NSF的法定使命,并通过使用基金会的知识价值和更广泛的影响审查进行评估,被认为值得支持的搜索.
项目成果
期刊论文数量(1)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Biaxial Murine Vaginal Remodeling With Reproductive Aging.
伴随生殖衰老的双轴小鼠阴道重塑。
- DOI:10.1115/1.4054362
- 发表时间:2022
- 期刊:
- 影响因子:0
- 作者:White,ShelbyE;Kiley,JasmineX;Visniauskas,Bruna;Lindsey,SarahH;Miller,KristinS
- 通讯作者:Miller,KristinS
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Kristin Miller其他文献
FEASIBILITY OF “FUNCTIONAL CORONARY INTERVENTION”
- DOI:
10.1016/s0735-1097(20)32079-9 - 发表时间:
2020-03-24 - 期刊:
- 影响因子:
- 作者:
Barry F. Uretsky;Shiv Kumar Agarwal;Rimsha Hasan;Srikanth Vallurupalli;Kristin Miller;Malek Al-Hawwas;Abdul Hakeem - 通讯作者:
Abdul Hakeem
Results from a type two hybrid‐effectiveness study to implement a preoperative anemia and iron deficiency screening, evaluation, and management pathway
实施术前贫血和缺铁筛查、评估和管理途径的二类混合有效性研究的结果
- DOI:
10.1111/trf.17287 - 发表时间:
2023 - 期刊:
- 影响因子:2.9
- 作者:
Alana Delaforce;S. Farmer;J. Duff;J. Munday;Kristin Miller;L. Glover;Chris Corney;Gareth Ansell;Naadir Gutta;H. Tuffaha;J. Hardy;C. Hurst - 通讯作者:
C. Hurst
Case Report: 52 Year-Old Male 11 Months after MUD for Angionimmunoblastic T Cell Lymphoma Developed Acute Fibrinous Organizing Pneumonitis Successfully Treated with Etanercept Suggesting TNF Alpha in the Pathogenesis in This Sub-Type of Pulmonary GVHD
- DOI:
10.1016/j.bbmt.2014.11.555 - 发表时间:
2015-02-01 - 期刊:
- 影响因子:
- 作者:
Gary Lee Simmons;William Clark;Harold Chung;Kristin Miller - 通讯作者:
Kristin Miller
Smartphone-Guided Self-prone Positioning vs Usual Care in Nonintubated Hospital Ward Patients With COVID-19
智能手机引导的自我俯卧位与非插管医院病房 COVID-19 患者的常规护理
- DOI:
- 发表时间:
2022 - 期刊:
- 影响因子:9.6
- 作者:
G. Rampon;Shijing Jia;R. Agrawal;Nicholas R Arnold;Alejandro Martín;Ernest A Fischer;J. Malatack;N. Jagan;Amen Sergew;A. Case;Kristin Miller;M. Tanios;G. Doros;C. Ross;Michael A. Garcia;Kari R. Gillmeyer;Nicholas G. Griffiths;B. Jandali;Katherine L. Modzelewski;J. Rucci;S. Simpson;A. Walkey;N. Bosch - 通讯作者:
N. Bosch
Pleuroparenchymal Fibroelastosis Associated With Autologous Stem Cell Transplant
- DOI:
10.1378/chest.1987087 - 发表时间:
2014-10-01 - 期刊:
- 影响因子:
- 作者:
Kristyn Sayball;Kristin Miller;Margaret Grimes;Harold Chung - 通讯作者:
Harold Chung
Kristin Miller的其他文献
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{{ truncateString('Kristin Miller', 18)}}的其他基金
Elastic Fiber Regeneration Potential During Postpartum Healing
产后愈合期间的弹性纤维再生潜力
- 批准号:
2326797 - 财政年份:2022
- 资助金额:
$ 49.17万 - 项目类别:
Standard Grant
CAREER: Determining the Dynamic Role of Elastic Fibers in Cervovaginal Adaptations
职业:确定弹性纤维在宫颈阴道适应中的动态作用
- 批准号:
1751050 - 财政年份:2018
- 资助金额:
$ 49.17万 - 项目类别:
Standard Grant
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