CAREER: Characterizing Nanoparticle Surface Interactions using Dissolution Dynamic Nuclear Polarization-Enhanced Nuclear Magnetic Resonance
职业:使用溶解动态核极化增强核磁共振表征纳米粒子表面相互作用
基本信息
- 批准号:1751529
- 负责人:
- 金额:$ 57.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:Continuing Grant
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-05-01 至 2024-09-30
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
This CAREER award, supported by the Chemical Measurement and Imaging Program in the Division of Chemistry with co-funding from the Established Program to Stimulate Competitive Research (EPSCoR), enables Professor Leah Casabianca and her group at Clemson University to develop new methods (based on Nuclear Magnetic Resonance (NMR) spectroscopy) for determination of the structure of biologically-relevant molecules interacting with the surface of nanoparticles. NMR is a powerful technique for determining the structure of molecules, including bond angles and distances not available through any other technique. Dr. Casabianca's work is important for understanding how nanoparticles behave when they enter the body, which is increasingly relevant as the use of nanoparticles in medicine and consumer products increases. The Casabianca group is using a combination of experimental solution-state NMR techniques, computer modeling, and innovative methods to improve the sensitivity of NMR and Magnetic Resonance Imaging (MRI) to determine the structure of peptides and proteins interacting with nanoparticle surfaces. The integrated educational aims of this work seek to increase the number of female and minority students in South Carolina who are excited about using computer science to solve problems in chemistry. This is being addressed by developing an undergraduate computational chemistry course, introducing computer programming into the junior-level quantum mechanics course, and creating fun and exciting lessons incorporating MRI and computer science for summer camps for middle-school girls.NMR is not ideally suited for surface studies due to its low sensitivity. To address this issue, the Casabianca lab is using Dynamic Nuclear Polarization (DNP) to enhance the NMR signal of nuclei near the nanoparticle surface. They are calibrating the distance dependence of polarization transfer from a nanoparticle surface to nearby nuclei and creating DNP-enhanced nanoparticle tracers for MRI. Broader impacts of this research will derive from the development of NMR methods for understanding interactions at the nanoparticle surface, which can be applied to nanoparticles used in applications such as drug delivery, catalysis, contrast agents, and biosensors. Broader impacts of the educational plan include increasing the number of female and minority students in South Carolina who are interested in computational chemistry.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.
这项职业奖由化学系化学测量和成像计划支持,并由既定的刺激竞争研究计划(EPSCoR)共同资助,使克莱姆森大学的Leah Casabianca教授和她的团队能够开发新的方法(基于核磁共振光谱)来确定与纳米颗粒表面相互作用的生物相关分子的结构。核磁共振是一种确定分子结构的强大技术,包括任何其他技术所无法获得的键角和距离。卡萨比安卡博士的工作对于了解纳米粒子进入人体后的行为很重要,随着纳米粒子在医药和消费品中的使用越来越多,这一点也越来越重要。Casabianca团队正在结合实验溶液状态核磁共振技术、计算机建模和创新方法来提高核磁共振和磁共振成像(MRI)的灵敏度,以确定与纳米颗粒表面相互作用的多肽和蛋白质的结构。这项工作的综合教育目标寻求增加南卡罗来纳州对使用计算机科学解决化学问题感到兴奋的女性和少数族裔学生的数量。解决这一问题的方法是开发一门本科计算化学课程,将计算机编程引入初级量子力学课程,并为中学女孩的夏令营创造结合核磁共振和计算机科学的有趣和令人兴奋的课程。由于核磁共振的敏感性较低,它不太适合表面研究。为了解决这个问题,卡萨比安卡实验室正在使用动态核极化(DNP)来增强纳米颗粒表面附近原子核的核磁共振信号。他们正在校准从纳米颗粒表面到附近原子核的偏振转移的距离依赖关系,并为核磁共振创建DNP增强的纳米颗粒示踪剂。这项研究的更广泛影响将来自于开发核磁共振方法来了解纳米颗粒表面的相互作用,这种方法可以应用于纳米颗粒在药物输送、催化、造影剂和生物传感器等应用中的应用。该教育计划的更广泛影响包括增加南卡罗来纳州对计算化学感兴趣的女性和少数族裔学生的数量。该奖项反映了NSF的法定使命,并通过使用基金会的智力优势和更广泛的影响审查标准进行评估,被认为值得支持。
项目成果
期刊论文数量(9)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
13C Saturation-Transfer Difference (STD)-NMR Experiments Using INEPT Polarization Transfer
- DOI:10.1007/s00723-019-01182-0
- 发表时间:2020-01
- 期刊:
- 影响因子:1
- 作者:Hui Xu;Daniel G. Lustig;L. Casabianca
- 通讯作者:Hui Xu;Daniel G. Lustig;L. Casabianca
Comprehensive Multiphase NMR Examination of Amino Acids Binding to the Dynamic Shell of Polystyrene Nanoparticles to Understand Environmental Hazards Associated with Nanoscale Plastic
- DOI:10.1021/acsanm.2c03597
- 发表时间:2022-11
- 期刊:
- 影响因子:5.9
- 作者:Rajshree Ghosh Biswas;R. Soong;Daniel Schmidig;Peter de Castro;Stephan Graf;F. Busse;A. Simpson;L. Casabianca
- 通讯作者:Rajshree Ghosh Biswas;R. Soong;Daniel Schmidig;Peter de Castro;Stephan Graf;F. Busse;A. Simpson;L. Casabianca
Probing Amino Acid Interaction with a Polystyrene Nanoparticle Surface Using Saturation-Transfer Difference (STD)-NMR
使用饱和传递差 (STD)-NMR 探测氨基酸与聚苯乙烯纳米颗粒表面的相互作用
- DOI:10.1021/acs.jpclett.8b02785
- 发表时间:2018
- 期刊:
- 影响因子:0
- 作者:Zhang, Yunzhi;Casabianca, Leah B.
- 通讯作者:Casabianca, Leah B.
Probing driving forces for binding between nanoparticles and amino acids by saturation-transfer difference NMR
通过饱和转移差核磁共振探测纳米粒子和氨基酸之间结合的驱动力
- DOI:10.1038/s41598-020-69185-7
- 发表时间:2020
- 期刊:
- 影响因子:4.6
- 作者:Xu, Hui;Casabianca, Leah B.
- 通讯作者:Casabianca, Leah B.
Dual Fluorescence and NMR Study for the Interaction between Xanthene Dyes and Nanoparticles
呫吨染料与纳米粒子相互作用的双荧光和核磁共振研究
- DOI:10.1021/acs.langmuir.0c03020
- 发表时间:2021
- 期刊:
- 影响因子:3.9
- 作者:Xu, Hui;Casabianca, Leah Beck
- 通讯作者:Casabianca, Leah Beck
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Leah Casabianca其他文献
Leah Casabianca的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Leah Casabianca', 18)}}的其他基金
CAS-MNP: Understanding the Interactions Between Small Molecules and Plastic Nanoparticles for Environmental Remediation and Sensing Using Nuclear Magnetic Resonance
CAS-MNP:了解小分子和塑料纳米颗粒之间的相互作用,用于环境修复和核磁共振传感
- 批准号:
2304888 - 财政年份:2023
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer with Cryoprobe
MRI:使用冷冻探针采集 500 MHz 核磁共振 (NMR) 波谱仪
- 批准号:
1725919 - 财政年份:2017
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
International Research Fellowship Program: Hyperpolarized Solid State NMR Spectra of Materials and Catalysis Using Dynamic Nuclear Polarization
国际研究奖学金计划:使用动态核极化的材料和催化的超极化固态核磁共振谱
- 批准号:
0965137 - 财政年份:2010
- 资助金额:
$ 57.5万 - 项目类别:
Fellowship Award
相似海外基金
Characterizing Transition to Turbulence in Pulsatile Pipe Flow
表征脉动管流中的湍流转变
- 批准号:
2335760 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
Research: Characterizing Gendered Socialization of Early Career Civil Engineers to Promote Inclusive Practices and Retention of a Diverse Workforce
研究:表征早期职业土木工程师的性别社会化,以促进包容性实践和保留多元化的劳动力
- 批准号:
2414042 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
Characterizing Pareto fronts: Trade-offs in the yeast growth cycle constrain adaptation
表征帕累托前沿:酵母生长周期的权衡限制了适应
- 批准号:
10749856 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
CAREER: Complexity Theory of Quantum States: A Novel Approach for Characterizing Quantum Computer Science
职业:量子态复杂性理论:表征量子计算机科学的新方法
- 批准号:
2339116 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Continuing Grant
Collaborative Research: Characterizing Atmospheric Tropical-waves of the Lower Stratosphere with Reel-down Atmospheric Temperature Sensing for Strateole-2--RATS Chasing CATS!
合作研究:利用 Strateole-2 的卷轴大气温度传感来表征平流层下部的大气热带波——RATS 追逐 CATS!
- 批准号:
2335083 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Continuing Grant
Collaborative Research: Characterizing Atmospheric Tropical-waves of the Lower Stratosphere with Reel-down Atmospheric Temperature Sensing for Strateole-2--RATS Chasing CATS!
合作研究:利用 Strateole-2 的卷轴大气温度传感来表征平流层下部的大气热带波——RATS 追逐 CATS!
- 批准号:
2335082 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Continuing Grant
ERI: Characterizing and improving algae-derived biofuel droplet burning
ERI:表征和改善藻类生物燃料液滴燃烧
- 批准号:
2301490 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
Women's voice: A new theory for characterizing the nature of female employee behavior
女性的声音:描述女性员工行为本质的新理论
- 批准号:
24K16417 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Grant-in-Aid for Early-Career Scientists
Collaborative Research: Determining the role of uranium(V) in the global uranium cycle by characterizing burial mechanisms in marine sinks
合作研究:通过表征海洋汇埋藏机制确定铀(V)在全球铀循环中的作用
- 批准号:
2322205 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant
Collaborative Research: Characterizing and empowering student success when traversing the academic help landscape
协作研究:在穿越学术帮助景观时描述并赋予学生成功的能力
- 批准号:
2336804 - 财政年份:2024
- 资助金额:
$ 57.5万 - 项目类别:
Standard Grant