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MRI: Acquisition of a 500 MHz Nuclear Magnetic Resonance (NMR) Spectrometer with Cryoprobe

MRI：使用冷冻探针采集 500 MHz 核磁共振 (NMR) 波谱仪

基本信息

批准号：
1725919
负责人：
Leah Casabianca
金额：
$ 47.82万
依托单位：
Clemson University
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2017
资助国家：
美国
起止时间：
2017-08-15 至 2020-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1725919&HistoricalAwards=false
关键词：
MRI Acquisition 500 MHz Nuclear

项目摘要

This award is supported by the Major Research Instrumentation (MRI), the Chemistry Research Instrumentation, and the Established Program to Stimulate Competitive Research (EPSCoR) Programs. Professor Leah Casabianca from Clemson University and colleagues Mark Thies, Julia Brumaghim, Sourav Saham, and Nishanth Tharayil are acquiring a 500 MHz nuclear magnetic resonance (NMR) spectrometer equipped with a cryoprobe. This spectrometer allows research in a variety of fields such as those that accelerate chemical reactions of significant economic importance, as well as the study of biologically-relevant species. In general, NMR spectroscopy is a powerful tool available to chemists for the structural study molecules. An NMR is used to identify unknown substances, to characterize specific arrangements of atoms within molecules, and to study the changing interactions between molecules in solution or in the solid state. The results from these NMR studies have an impact in synthetic organic/inorganic chemistry, materials chemistry, forensics, and biochemistry. This instrument is an integral part of teaching as well as research performed by undergraduate students. Students from a Research Experiences for Undergraduates (REU) program are also involved in the use of the instrument.This NMR spectrometer enhances research and education at all levels. It benefits researchers exploring selenium antioxidant mechanisms using 77-selenium NMR spectroscopy, studying nanoparticle toxicity, and determining dynamic time and length scales in ionic polymers. The instrumentation is employed in studying anion and ion pair recognition and stimuli-responsive functional materials. Researchers are analyzing bioconjugates of carbon quantum dots and carrying out biogeochemical research on soil carbon sequestration. The spectrometer is also used for studying fluorine chemistry, tailoring lignin properties for high-value applications, synthesizing peptoid polymers, and studying applications to synthetic organic chemistry.

该奖项由主要研究仪器（MRI），化学研究仪器和刺激竞争性研究（EPSCoR）计划的既定计划支持。来自克莱姆森大学的Leah Casabianca教授及其同事Mark Thies，Julia Brumaghim，Sourav萨哈姆和Nishanth Tharayil正在获得一台配备冷冻探针的500 MHz核磁共振（NMR）光谱仪。该光谱仪可用于各种领域的研究，例如加速具有重要经济意义的化学反应，以及生物相关物种的研究。通常，NMR光谱是化学家用于结构研究分子的强有力工具。NMR用于识别未知物质，表征分子内原子的特定排列，并研究溶液或固态分子之间的相互作用变化。这些NMR研究的结果对合成有机/无机化学、材料化学、法医学和生物化学产生了影响。该仪器是本科生进行教学和研究的一个组成部分。来自本科生研究经验（REU）项目的学生也参与了仪器的使用。这台核磁共振光谱仪增强了各个层次的研究和教育。它有利于研究人员使用77-硒NMR光谱探索硒抗氧化机制，研究纳米颗粒毒性，并确定离子聚合物中的动态时间和长度尺度。该仪器用于研究阴离子和离子对识别和刺激响应功能材料。研究人员正在分析碳量子点的生物共轭物，并开展土壤固碳的地球化学研究。该光谱仪还用于研究氟化学，为高价值应用定制木质素特性，合成类肽聚合物，以及研究合成有机化学的应用。

项目成果

期刊论文数量（10）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

13C Saturation-Transfer Difference (STD)-NMR Experiments Using INEPT Polarization Transfer

DOI：
10.1007/s00723-019-01182-0
发表时间：
2020-01
期刊：
Applied Magnetic Resonance
影响因子：
1
作者：
Hui Xu;Daniel G. Lustig;L. Casabianca
通讯作者：
Hui Xu;Daniel G. Lustig;L. Casabianca

Pt(ii)-coordinated tricomponent self-assemblies of tetrapyridyl porphyrin and dicarboxylate ligands: are they 3D prisms or 2D bow-ties?

DOI：
10.1039/d1sc06533e
发表时间：
2022-04-06
期刊：
Chemical science
影响因子：
8.4
作者：
Benavides PA;Gordillo MA;Yadav A;Joaqui-Joaqui MA;Saha S
通讯作者：
Saha S

Design and synthesis of Fmoc-SPPS-ready iodoarene amino acid pre-catalysts and their reactivity in the catalytic oxytosylation of ketones

Fmoc-SPPS-ready 碘芳烃氨基酸预催化剂的设计与合成及其在酮催化氧化中的反应活性

DOI：
10.1016/j.tetlet.2020.151723
发表时间：
2020
期刊：
Tetrahedron Letters
影响因子：
1.8
作者：
Lex, Timothy R.;Swasy, Maria I.;Panda, Soham;Brummel, Beau R.;Giambalvo, Lauren N.;Gross, Kristopher G.;McMillen, Colin D.;Kobra, Khadijatul;Pennington, William T.;Whitehead, Daniel C.
通讯作者：
Whitehead, Daniel C.

Rare Guest-Induced Electrical Conductivity of Zn-Porphyrin Metallacage Inclusion Complexes Featuring π-Donor/Acceptor/Donor Stacks