REU Site: Undergraduate Research Experience in Biomedical Translational Science and Technology Development

REU 网站：生物医学转化科学与技术开发的本科生研究经验

• 批准号: 1757846
• 负责人: Kaiming Ye
• 金额: $ 36.17万
• 依托单位: SUNY at Binghamton
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=1757846&HistoricalAwards=false
• 关键词: REU; Site; Undergraduate; Research; Experience

The rapid expansion of biomedical science has resulted in a short supply of biomedical scientists and engineers at all career levels, presenting an immediate need to educate and train more young people in the skills and knowledge required for biomedical science and engineering. To meet this demand, Binghamton University (BU-SUNY) will host a 10-week summer REU program to train 10 undergraduate students per year in translational biomedical science and engineering. The program will offer undergraduates intensive multidisciplinary hands-on research and professional development training in integrated biomedical translational science and technology development. The program is anticipated to develop a leadership pipeline helping students advance in either their graduate studies or career and professional training in these fields. The teaming of biomedical scientists with engineers has led to the development of this novel and unique REU program. The fourteen participating faculty members combined have trained nearly 684 REU students, leading to 80 peer-reviewed research articles co-authored by undergraduates. BU's strong commitment to undergraduate education and research will ensure the success of the proposed REU program. The broad and cohesive research interests of faculty mentors involved in this program allow for designing and implementing a vigorous summer REU program to offer T-shaped professional training opportunities to undergraduates. Efforts will be made to recruit students from underrepresented groups, such as women, minority students and students from undergraduate institutions and community colleges where undergraduate research training is limited. The outcome of the REU program will be disseminated at national conferences and published in peer-reviewed journals.The REU program will provide students with opportunities to learn how engineering principles can be integrated with medical and life sciences to translate biomedical discoveries into bedside technologies for treating many diseases, such as diabetes and cancers. The program will expose students to medical science, biology, biochemistry, pharmaceutical sciences, neuroscience and cognitive science, as well as to tissue engineering, materials sciences, nanofabrications, genome editing, RNA transcriptome analysis, 3D bioprinting, cell manufacturing, and tissue biofabrication. Interactive workshops covering topics related to biomedical engineering and graduate studies and career development training will inform students of the latest developments in the fields of biomedical science and engineering and professional development opportunities in these fields. Social events related to the REU program will allow students to interact with other REU students on campus facilitating peer learning and collegiality. Field trips to industry sites will introduce students to applications of biotechnology development. The combination of research training, workshops, social events, and field trips will provide students with a foundation in biomedical engineering research, which they can apply to enriching their professional development.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

生物医学科学的迅速发展导致各个职业层次的生物医学科学家和工程师短缺，迫切需要教育和培训更多的年轻人掌握生物医学科学和工程所需的技能和知识。为了满足这一需求，宾厄姆顿大学（BU-SUNY）将举办为期10周的夏季REU课程，每年培训10名本科生转化生物医学科学和工程。该计划将为本科生提供密集的多学科实践研究和综合生物医学转化科学和技术发展的专业发展培训。该计划预计将开发一个领导力管道，帮助学生在这些领域的研究生学习或职业和专业培训中取得进步。生物医学科学家与工程师的合作导致了这个新颖而独特的REU计划的发展。14名参与教师共培训了近684名REU学生，导致80篇由本科生合著的同行评议研究文章。BU对本科教育和研究的坚定承诺将确保拟议的REU计划的成功。参与该计划的教师导师的广泛和有凝聚力的研究兴趣允许设计和实施一个充满活力的夏季REU计划，为本科生提供T形专业培训机会。将努力从代表性不足的群体中招收学生，如妇女、少数民族学生以及本科研究培训有限的本科院校和社区学院的学生。REU项目的成果将在全国性会议上传播，并发表在同行评议的期刊上。REU项目将为学生提供学习如何将工程原理与医学和生命科学相结合的机会，将生物医学发现转化为治疗糖尿病和癌症等多种疾病的床边技术。该计划将使学生接触医学，生物学，生物化学，制药科学，神经科学和认知科学，以及组织工程，材料科学，纳米制造，基因组编辑，RNA转录组分析，3D生物打印，细胞制造和组织生物制造。互动研讨会涵盖与生物医学工程和研究生学习和职业发展培训相关的主题，将告知学生生物医学科学和工程领域的最新发展以及这些领域的专业发展机会。与REU计划相关的社交活动将允许学生与校园内的其他REU学生互动，促进同伴学习和合作。到工业现场的实地考察将向学生介绍生物技术发展的应用。研究培训、研讨会、社会活动和实地考察的结合将为学生提供生物医学工程研究的基础，他们可以应用这些基础来丰富他们的专业发展。该奖项反映了NSF的法定使命，并通过使用基金会的智力价值和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

Inducing Tumor Suppressive Microenvironments through Genome Edited CD47−/− Syngeneic Cell Vaccination

• DOI: 10.1038/s41598-019-56370-6
• 发表时间: 2019-12
• 期刊: Scientific Reports
• 影响因子: 4.6
• 作者: Subhadra Jayaraman Rukmini;Huanjing Bi;Puloma Sen;B. Everhart;Sha Jin;K. Ye