Neurofeedback for Adult Attention-Defizit-/Hyperactivity Disorder (ADHD): A proof of principle comparison of Slow Cortical Potentials and Near-Infrared-Feedback with Placebo Treatment

注意缺陷多动障碍（ADHD）的特征是注意力不集中、冲动和多动。到目前为止，只有少数研究调查了成年人的注意力缺陷多动症，而研究神经反馈训练等新形式治疗的研究就更少了。神经反馈训练已被有效地应用于各个领域，特别是在儿童多动症的治疗中。本研究旨在探讨慢皮质电位（SPC）神经反馈训练和一种新形式的近红外光谱（NIRS）神经反馈对成年ADHD人群症状学和神经生理参数的影响。SCP和NIRS神经反馈治疗方法的比较以前没有进行过，可能会对成人ADHD的替代治疗产生有价值的发现。这两种神经反馈技术的结果将在30次训练和6个月的随访期后进行评估，并与安慰剂训练进行比较。此外，为了研究这项原理证明研究中的训练效果是否可以通过特定的神经生理基线参数来预测，我们将使用回归模型。最后，将与健康对照进行比较，以评估偏离训练前的神经生理参数，评估措施的稳定性和治疗结果。

Attention deficit hyperactivity disorder (ADHD) is characterized by symptoms of inattention, impulsivity, and hyperactivity. Hitherto, only a few studies have investigated ADHD in an adult population and even less have investigated new forms of treatment such as neurofeedback training. Neurofeedback training has been applied effectively in various areas, especially in the treatment of children with ADHD. This study is designed to investigate the effect of slow cortical potentials (SPC) neurofeedback training and a new form of neurofeedback using near-infrared spectroscopy (NIRS) on symptomatology and neurophysiological parameters in an adult ADHD population.A comparison of SCP and NIRS neurofeedback therapy methods has not been previously conducted and may yield valuable findings about alternative treatments for adult ADHD. The outcome of both neurofeedback techniques will be assessed over 30 training sessions and after a six month follow-up period and compared to placebo training. Furthermore, to investigate if training effects in this proof of principle study can be predicted by specific neurophysiological baseline parameters, regression models will be applied. Finally, a comparison with healthy controls will be conducted to evaluate deviant pre-training neurophysiologic parameters, stability of assessment measures, and treatment outcome.