Interference control and inhibition in adult attention deficit hyperactivity disorder (ADHD)

成人注意力缺陷多动障碍（ADHD）的干扰控制和抑制

• 批准号: 228454680
• 负责人: Professorin Dr. Anya Pedersen
• 金额: --
• 依托单位: Institut für Psychologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2013
• 资助国家: 德国
• 起止时间: 2012-12-31 至 2016-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/228454680?language=en
• 关键词: Interference; control; inhibition; adult; attention

Attention Deficit Hyperactivity Disorder (ADHD), a frequent psychological disorder in adults with a prevalence rate of approx. 4.4%, is often a chronic condition associated with severe impairments in social outcome. Identifying neurocognitive deficits is relevant for the pathogenesis of ADHD. Two competing models of ADHD guide neuroscognitive research: According to Barkley (1997) ADHD symptoms are a secondary manifestation of behavioral inhibition which comprises aspects of deficient interference control and motor inhibition, whereas Nigg et al. (2005) conceptualize ADHD as a consequence of impaired motor inhibition. For the first time both aspects - interference control and motor inhibition - are investigated in a combined paradigm. In addition, recent contradictory findings might reflect effects of task load: paradigms, which reveal strong interference or inhibition effects in healthy controls, might lead to floor effects. Hence, variation of task load is implemented in the present study. Event related potentials (error-related negativity and error-related positivity) are used to decompose deficient processes of interference and inhibition. Identifying specific neuropsychological deficits, which correlate with electrophysiological parameters, might guide future research as potential endophenotypes of ADHD.

注意缺陷多动障碍（ADHD），一种常见的心理障碍，在成年人中的患病率约为。4.4%，通常是一种慢性疾病，与社会结果的严重损害有关。识别神经认知缺陷与ADHD的发病机制有关。ADHD的两个相互竞争的模型指导神经症状学研究：根据Barkley（1997），ADHD症状是行为抑制的次要表现，包括干扰控制不足和运动抑制，而Nigg等人（2005）将ADHD概念化为运动抑制受损的结果。第一次这两个方面-干扰控制和电机抑制-在一个组合的范例进行了研究。此外，最近矛盾的研究结果可能反映了任务负荷的影响：范式，这表明在健康对照强烈的干扰或抑制作用，可能会导致地板效应。因此，在本研究中，任务负荷的变化。事件相关电位（错误相关负性和错误相关正性）用于分解干扰和抑制的缺陷过程。识别与电生理参数相关的特定神经心理缺陷，可能会指导未来的研究，作为ADHD的潜在内在表型。

项目成果

Deficient interference control during working memory updating in adults with ADHD: An event-related potential study

• DOI: 10.1016/j.clinph.2015.05.021
• 发表时间: 2016-01
• 期刊: Clinical Neurophysiology
• 影响因子: 4.7
• 作者: D. Stroux;A. Shushakova;A. Shushakova;A. J. Geburek-Höfer;Patricia Ohrmann;Fred Rist;A. Pedersen;A. Pedersen

Hyperactivity and impulsivity in adult attention-deficit/hyperactivity disorder is related to glutamatergic dysfunction in the anterior cingulate cortex

• DOI: 10.1080/15622975.2016.1262060
• 发表时间: 2018-01-01
• 期刊: WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY
• 影响因子: 3.1
• 作者: Bauer, Jochen;Werner, Anne;Ohrmann, Patricia
• 通讯作者: Ohrmann, Patricia