权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

The Role of the Eye's Peri-limbal Tissue and Integral Veins on Intraocular Pressure

眼睛的角膜缘周围组织和整体静脉对眼压的作用

基本信息

批准号：
1760291
负责人：
Alan Argento
金额：
$ 42.02万
依托单位：
Regents of the University of Michigan - Ann Arbor
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2018
资助国家：
美国
起止时间：
2018-09-01 至 2022-08-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=1760291&HistoricalAwards=false
关键词：
Role Eye Peri limbal Tissue

项目摘要

The mechanical properties of the eye tissues around the outer rim of the cornea (peri-limbal scleral tissue) contains veins that allow drainage from the clear jelly (aqueous humor) of the inside of the eye. The peri-limbal tissues are part of the mechanism that the eye uses to control eye pressure. This research will test whether the mechanical properties of the peri-limbal tissues changes how the veins control eye pressure. The research goals are to: (1) measure the deformation in the tissues supporting the veins as outflow occurs; (2) determine the relationships between peri-limbal tissue mechanical properties and deformation with the eye's intraocular pressure; (3) determine the mechanical mechanisms by which the peri-limbal scleral tissues influence the veins' ability to carry fluid from the eye. The objectives will be pursued through microscopic imaging of the deforming peri-limbal sclera of eyes under experimental perfusion. Fluorescent nanospheres in artificial aqueous infused into the eye will create trackable markers that will be used to measure deformation. A computer model of the fluid-structure interaction based on the experimental data will be created for the microstructural anatomy of the peri-limbal sclera and the included veins. Elevated eye pressure is often implicated in glaucoma and affects about 10% of the population over age 40, making it one of the leading causes of irreversible blindness. This research will further public health by discovering some of the basic causes of eye pressure increase in glaucoma. Capstone design projects and educational module for the principal investigators soft tissue class will be developed based on the research. More than six students will work on this interdisciplinary project, as well as two undergraduates for each year of the project. These students will come from engineering, natural science and medicine on the two University of Michigan campuses and neighboring institutions to expand the project's impact.The imaging will be conducted within the eye's tissues, not on the surface. This will produce new knowledge about the interaction of veins and the surrounding soft tissue as well as the transfer of intraocular pressure through the sclera and to the veins. Other than understanding that the aqueous venous system creates a back-pressure, little is known about the relationship between its structural details and outflow; such knowledge will be developed in this project. Knowledge will also result on the relationships between the viscoelastic tissue properties, strains and eye pressure. This knowledge has direct relevance to glaucoma in eyes having high pressure. Furthermore, because the viscoelastic tissue properties are strongly tied to components of the extracellular matrix and its remodeling, knowledge will occur that has application to aging and tissue disorders. The techniques and knowledge produced in normal peri-limbal sclera can be applied to diabetic tissues to better understand the differences in biomechanics and deformation in tissues with advanced glycation end products, a suspected cause of tissue stiffening. The methods used and knowledge gained will inform understanding of other tissues of the body where soft tissue and fluid acconveying vessels interact such as the renal tubules, cerebral veins, and retinal veins.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

角膜外缘周围的眼组织(角膜缘周围巩膜组织)的机械性能包含允许从眼内透明的凝胶(房水)中引流的静脉。角膜缘周围组织是眼睛控制眼压的机制的一部分。这项研究将测试角膜缘周围组织的机械性能是否会改变静脉控制眼压的方式。研究的目标是：(1)测量流出时支撑静脉的组织中的变形；(2)确定角膜缘周围组织的力学性质和变形与眼内压的关系；(3)确定角膜缘周围巩膜组织影响静脉从眼内输送液体的力学机制。这些目标将通过对实验性灌流下变形的眼缘周围巩膜进行显微成像来实现。将人造水中的荧光纳米球注入眼睛将产生可跟踪的标记，用于测量变形。将根据实验数据建立流固耦合的计算机模型，用于对巩膜周缘及其周围静脉的显微结构解剖。眼压升高通常与青光眼有关，并影响到约10%的40岁以上人口，使其成为导致不可逆转失明的主要原因之一。这项研究将通过发现青光眼眼压增加的一些基本原因来进一步促进公共健康。在研究的基础上，将开发针对首席调查员软组织课程的顶石设计项目和教育模块。超过六名学生将参与这个跨学科的项目，以及每年项目中的两名本科生。这些学生将来自密歇根大学两个校区和邻近机构的工程、自然科学和医学专业，以扩大该项目的影响。成像将在眼睛组织内进行，而不是在表面。这将产生关于静脉与周围软组织的相互作用以及眼压通过巩膜传递到静脉的新知识。除了了解房水静脉系统产生背压外，我们对其结构细节和外流之间的关系知之甚少；这种知识将在这个项目中得到发展。此外，还将了解粘弹性组织特性、应变和眼压之间的关系。这一知识与眼压过高的青光眼有直接关系。此外，由于粘弹性组织属性与细胞外基质的成分及其重塑密切相关，因此将出现可应用于衰老和组织紊乱的知识。在正常的角膜缘周围巩膜中产生的技术和知识可以应用于糖尿病组织，以更好地了解晚期糖基化终产物组织中的生物力学差异和变形，这可能是导致组织僵硬的原因之一。所使用的方法和获得的知识将有助于了解软组织和液体输送血管相互作用的身体其他组织，如肾小管、脑静脉和视网膜静脉。该奖项反映了NSF的法定使命，并通过使用基金会的智力优势和更广泛的影响审查标准进行评估，被认为值得支持。

项目成果

期刊论文数量（8）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Resolving the anatomy of aqueous veins and perilimbal sclera using multispectral photoacoustic imaging

使用多光谱光声成像解析房水静脉和角膜缘周围巩膜的解剖结构

DOI：
发表时间：
2021
期刊：
2021
影响因子：
0
作者：
Zhang, W;Riesterer, J;Kim, W;Paulus, Y;Wang, X;Moroi, S;Argento, A.
通讯作者：
Argento, A.

Method for the biomechanical analysis of aqueous veins and perilimbal sclera by three-dimensional photoacoustic imaging and strain field calculation.

DOI：
10.1038/s41598-021-01458-1
发表时间：
2021-11-11
期刊：
Scientific reports
影响因子：
4.6
作者：
Ni L;Riesterer J;Wang H;Berry L;Blackburn K;Chuang J;Kim W;Xu G;Moroi SE;Argento A
通讯作者：
Argento A

Photoacoustic imaging as a tool for assessing the biomechanical behavior of aqueous veins and perilimbal sclera complex

光声成像作为评估房水静脉和角膜缘巩膜复合体生物力学行为的工具

DOI：
发表时间：
2020
期刊：
International Ultrasound Symposium 2020
影响因子：
0
作者：
Riesterer, J;Kim, W;Berry, L;Blackburn, K;Chuang, J;Wang, H;Zhang, W;Paulus, Y
通讯作者：
Paulus, Y

Resolving the complex anatomy of aqueous veins and perilimbal sclera using multispectral photoacoustic imaging

使用多光谱光声成像解决房水静脉和角膜缘周围巩膜的复杂解剖结构