Beyond pineal melatonin: sensing the seasons without the eye

超越松果体褪黑激素：不用眼睛感知季节

• 批准号: DP240101413
• 负责人: Prof Claire Wade
• 金额: $ 35.03万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2024
• 资助国家: 澳大利亚
• 起止时间: 2024-03-01 至 2027-02-28
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP240101413
• 关键词: Beyond; pineal; melatonin; sensing; seasons

The project will identify the causal connection between seasonal breeding in animals and a recently recognised brain biochemical pathway by applying experimental treatments mimicking seasonal environmental changes in a mutant and wild-type nematode worm model. Through experimentation we will identify useful biological targets that might be manipulated to enhance control of seasonal breeding in managed animals. With better control of reproductive output in animals, farmers and managers can increase and/or decrease reproductive output as needed in managed species including livestock and vertebrate pests. This will enhance the use of precious land resources and minimize ecological damage from overbreeding.

该项目将通过在突变体和野生型线虫模型中应用模拟季节性环境变化的实验治疗，确定动物季节性繁殖与最近公认的大脑生化途径之间的因果关系。通过实验，我们将确定有用的生物靶点，可以操纵这些靶点以加强对管理动物季节性繁殖的控制。通过更好地控制动物的生殖输出，农民和管理人员可以根据需要增加和/或减少管理物种（包括牲畜和脊椎动物害虫）的生殖输出。此举可善用珍贵的土地资源，并尽量减少过度繁殖对生态的破坏。