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Analysis of the performance-enhancing effects of hippocampal lesions in rat serial reaction time task

海马损伤对大鼠系列反应时任务的性能增强作用分析

基本信息

批准号：
232681559
负责人：
Professor Dr. Rainer K.W. Schwarting
金额：
--
依托单位：
Abteilung Verhaltensneurowissenschaft
依托单位国家：
德国
项目类别：
Research Grants
财政年份：
2013
资助国家：
德国
起止时间：
2012-12-31 至 2017-12-31
项目状态：
已结题

来源：
https://gepris.dfg.de/gepris/projekt/232681559?language=en
关键词：
Analysis performance enhancing effects hippocampal

项目摘要

Sequential learning is a basic form of knowledge acquisition, namely implicit or procedural learning, which is tested in humans and primates using serial reaction time tasks. In Parkinson patients and by use of brain imaging techniques, it could be shown that fronto-striatal and dopaminergic processed play a central role in sequential behavior. We have developped a rat version with high face validity of the serial reaction time task to study neural mechanisms including manipulative approaches, and our translational studies to validate the test showed that dopamine lesions can impair sequential behavior, especially during learning. More recently, we studied the hippocampus, which is thought to play a role for explicit and spatial learning and memory. Surprisingly, we repeatedly found that lesions of the hippocampus substantially enhanced performance in our task, which supports the hypothesis that simultaneous information provided by basal ganglia and hippocampus to frontal cortical sites can compete with each other during sequential learning and that hippocampal information may not play a crucial role during sequential learning. Here, we want to address some yet unresolved questions regarding this lesion effect: a) Is the performance-enhancing effect specific for sequential learning or does it improve instrumental learning which is required in our task, b) are lesions of the intermediate hippocampus, which provided important inputs to frontal cortical sites, sufficient for the effect?, and c) are the effects specific for task acquisition and can they also be induced by reversible pharmacological blockade of the hippocampus?

序列学习是知识获取的一种基本形式，即内隐学习或程序学习，它在人类和灵长类动物中使用序列反应时间任务进行了测试。在帕金森患者中，通过使用脑成像技术，可以表明额纹状体和多巴胺能处理在序列行为中起着核心作用。我们已经开发了一个大鼠版本，具有高表面效度的系列反应时间任务，以研究神经机制，包括操纵方法，我们的翻译研究，以验证该测试表明，多巴胺损伤会损害顺序行为，特别是在学习过程中。最近，我们研究了海马体，它被认为在外显和空间学习和记忆中发挥作用。令人惊讶的是，我们反复发现，海马的病变大大提高了我们的任务，这支持了这一假设，同时提供的信息基底神经节和海马额叶皮质网站可以相互竞争，在顺序学习和海马信息可能不会发挥关键作用，在顺序学习。在这里，我们想解决一些尚未解决的问题，关于这种病变的影响：a）性能增强效果是特定的顺序学习或它是否改善工具性学习，这是我们的任务所需的，B）是中间海马病变，提供了重要的输入到额叶皮层网站，足以为效果？，和c）这些效应是否对任务获得具有特异性，它们是否也可以通过海马的可逆药理学阻断来诱导？