Metal Mediated and Catalyzed Organic Synthetic Methods
金属介导和催化的有机合成方法
基本信息
- 批准号:RGPIN-2016-04946
- 负责人:
- 金额:$ 1.82万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2017
- 资助国家:加拿大
- 起止时间:2017-01-01 至 2018-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The objective of the proposed research is to develop and understand a series of novel organic chemical reactions mediated by transition metal complexes or catalyzed by either transition metal complexes or main group compounds. The goals include the development of types of carbon-carbon bond forming reactions not normally readily accomplished by traditional organic chemical processes (i.e., the pattern of reactivity is inverted that which is ‘natural’ in most organic compounds), and to prepare and use compounds that could not normally exist if it were not for the presence of the metal unit. In particular the proposed metal catalyzed allylation reactions, in conjunction with other catalytic reactions, are designed for being catalytic methods of giving this inverted pattern of reactivity. The proposed chemistry alkynedicobalt complexes are designed to make possible in extended synthetic chemistry the use of compounds that could not be isolated if not for the cobalt atoms. The ultimate goal for the reactions investigated is to develop the chemistry to the point where it can be used in the synthesis of organic molecules of importance, such as compounds that have potential anti-cancer properties, antileukemic properties, antibacterial or insect antifeedant activity. In many cases, the organic compounds simply have interesting structures, and in other cases the prepared compounds are designed to address or challenge question of the fundamental properties of chemical compounds, such as what makes such a compound stable (or unstable).
该研究的目的是开发和理解一系列由过渡金属配合物介导或由过渡金属配合物或主族化合物催化的新型有机化学反应。这些目标包括开发通常不容易通过传统有机化学方法完成的碳-碳键形成反应的类型(即,反应性模式与大多数有机化合物中的“天然”反应性模式相反),以及制备和使用如果没有金属单元的存在则不能正常存在的化合物。特别地,所提出的金属催化的烯丙基化反应与其他催化反应结合,被设计为提供这种反向反应性模式的催化方法。所提出的化学炔二钴络合物被设计为使得在扩展的合成化学中使用如果没有钴原子则不能分离的化合物成为可能。研究反应的最终目标是将化学发展到可以用于合成重要有机分子的程度,例如具有潜在抗癌特性,抗白血病特性,抗菌或昆虫拒食活性的化合物。在许多情况下,有机化合物只是具有有趣的结构,而在其他情况下,所制备的化合物旨在解决或挑战化合物的基本性质的问题,例如是什么使这种化合物稳定(或不稳定)。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Green, James其他文献
Quality and Variability of Patient Directions in Electronic Prescriptions in the Ambulatory Care Setting.
- DOI:
10.18553/jmcp.2018.17404 - 发表时间:
2018-07 - 期刊:
- 影响因子:2.1
- 作者:
Yang, Yuze;Ward-Charlerie, Stacy;Dhavle, Ajit A.;Rupp, Michael T.;Green, James - 通讯作者:
Green, James
Internet use in an orthopaedic outpatient population
- DOI:
10.1097/bco.0b013e31828e542b - 发表时间:
2013-05-01 - 期刊:
- 影响因子:0.3
- 作者:
Baker, Joseph F.;Green, James;Mulhall, Kevin J. - 通讯作者:
Mulhall, Kevin J.
Child pedestrian casualties and deprivation
- DOI:
10.1016/j.aap.2010.10.016 - 发表时间:
2011-05-01 - 期刊:
- 影响因子:5.9
- 作者:
Green, James;Muir, Helen;Maher, Mike - 通讯作者:
Maher, Mike
Correlates of head circumference growth in infants later diagnosed with autism spectrum disorders
- DOI:
10.1177/0883073807304005 - 发表时间:
2007-06-01 - 期刊:
- 影响因子:1.9
- 作者:
Mraz, Krista D.;Green, James;Fein, Deborah - 通讯作者:
Fein, Deborah
Call for a framework for reporting evidence for life beyond Earth
- DOI:
10.1038/s41586-021-03804-9 - 发表时间:
2021-10-28 - 期刊:
- 影响因子:64.8
- 作者:
Green, James;Hoehler, Tori;Voytek, Mary - 通讯作者:
Voytek, Mary
Green, James的其他文献
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{{ truncateString('Green, James', 18)}}的其他基金
Reciprocal Perspective Machine Learning to Identify Relationships in Sparse Biological Networks
交互视角机器学习识别稀疏生物网络中的关系
- 批准号:
RGPIN-2021-04184 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Metal Mediated and Catalyzed Organic Synthetic Methods
金属介导和催化的有机合成方法
- 批准号:
RGPIN-2022-04761 - 财政年份:2022
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Unobtrusive neonatal patient monitoring using video and pressure data
使用视频和压力数据进行不引人注目的新生儿患者监测
- 批准号:
543940-2019 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Reciprocal Perspective Machine Learning to Identify Relationships in Sparse Biological Networks
交互视角机器学习识别稀疏生物网络中的关系
- 批准号:
RGPIN-2021-04184 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Metal Mediated and Catalyzed Organic Synthetic Methods
金属介导和催化的有机合成方法
- 批准号:
RGPIN-2016-04946 - 财政年份:2021
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Effective prediction of microRNAs in the face of class imbalance
面对类别不平衡时有效预测 microRNA
- 批准号:
RGPIN-2016-06179 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Metal Mediated and Catalyzed Organic Synthetic Methods
金属介导和催化的有机合成方法
- 批准号:
RGPIN-2016-04946 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Unobtrusive neonatal patient monitoring using video and pressure data
使用视频和压力数据进行不引人注目的新生儿患者监测
- 批准号:
543940-2019 - 财政年份:2020
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
Effective prediction of microRNAs in the face of class imbalance
面对类别不平衡时有效预测 microRNA
- 批准号:
RGPIN-2016-06179 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Discovery Grants Program - Individual
Unobtrusive neonatal patient monitoring using video and pressure data
使用视频和压力数据进行不引人注目的新生儿患者监测
- 批准号:
543940-2019 - 财政年份:2019
- 资助金额:
$ 1.82万 - 项目类别:
Collaborative Research and Development Grants
相似海外基金
Metal Mediated and Catalyzed Organic Synthetic Methods
金属介导和催化的有机合成方法
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